Topic: Ribociclib/Kisqali with Letrozole - Any one on this combo?

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: May 19, 2017 02:58PM

Posted on: May 19, 2017 02:58PM

s3k5 wrote:

I am starting this new forum for all those who are on this newly approved drug combo. I started on Kisqali/Letrozole combo 6 weeks ago and so far it has been tolerable. Letrozole gives me joint pain and low back pain. My oncologist has asked me to take this on alternate days. Would love to hear from others about their experience with this therapy.

S3K5 Dx 3/24/2008, IDC, Right, 3cm, Stage IIIA, Grade 2, 5/10 nodes, ER+/PR+, HER2- Chemotherapy 4/15/2008 AC + T (Taxol) Targeted Therapy 5/30/2013 Ibrance (palbociclib) Hormonal Therapy 9/1/2014 Faslodex (fulvestrant) Chemotherapy 2/1/2019 Xeloda (capecitabine) Chemotherapy 4/5/2019 Taxol (paclitaxel) Chemotherapy 10/30/2019 CMF Targeted Therapy 7/7/2020 Piqray (alpelisib) Dx 10/19/2020, IDC, Right, Stage IV, metastasized to bone/liver, ER-/PR-, HER2- Chemotherapy 12/10/2020 Doxil (doxorubicin) Hormonal Therapy Femara (letrozole) Chemotherapy Gemzar (gemcitabine)
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Jun 22, 2022 09:08AM mozuke1 wrote:

hi ddil, I can’t speak to longevity, as I have only been on Kisqali (and Letrozole) for 2 months, but I have had next to no symptoms. My blood counts are, of course, low, but within acceptable range and I have been feeling great! I have labs next week, so we'll see what they show. My last PET scan was in Mar and I’ll have another in Aug to see how things are going.

I can’t remember what shows up in my profile, but I am also de novo lobular with bone Mets. I did a course of chemo after diagnosis in Oct and had BSO/hysterectomy before starting Kisqali 4/25

Dx 10/2021, ILC, Right, Stage IV, metastasized to bone, ER+/PR+, HER2- Chemotherapy 10/28/2021 AC + T (Taxol) Chemotherapy 10/29/2021 AC + T (Taxol)
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Jun 25, 2022 11:22AM kanga_roo wrote:

hi Holiwoman, I don’t think timing matters with booster shots, hope all goes well for her!

ddil, I really hope the combo works for you! People on this thread report side effects in the first month, but then things seem to settle down. Most of us have had it as a first line of treatment, so will be interested to hear how you go. Keep us posted and there is usually someone here who can answer any questions you might have

Dx 1/24/2018, IDC, Left, 5cm, Stage IV, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 2/11/2018 Femara (letrozole) Targeted Therapy 2/15/2018 Kisqali

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