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Topic: Study on GDC0077

Forum: Stage IV and Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Jul 29, 2017 04:13AM

babs6287 wrote:

I am about to start study of GDC 0077. In preparation for this I have to do the following:

1-yesterday-

a-met with the study Dr to sign the forms b-had a complete eye exam

2-today-

a-had blood tests, ekg, blood pressure, weight, and urine taken

b-ct scan done

3-Next week- liver biopsy

I start the actual trial on Thursday August 10th- will keep you all informed as to what transpires. I was on Halaven but my TMs were rising like crazy so my oncologist looked into a study for me and found the one below which targets my particular mutation found during Assay Impact Testing at MSKCC. I also had a PET/CT that showed slight improvement while on Halaven (I only had 3 sessions) But my MO and I decided that I should go into the trial and if it doesn't work. I can always go back on Halaven. For me, there was no choice. My veins are shot and I needed a rest from IV chemo. Taking pills seems like an easier way to go. Plus, I am traveling a lot now so doing chemo wouldn't really work.


A Phase I, Open-Label, Dose-Escalation Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0077 as a Single Agent in Patients with Locally Advanced or Metastatic PIK3CA-Mutant Solid Tumors and in Combination with Endocrine and Targeted Therapies in Patients with Locally Advanced or Metastatic PIK3CA-Mutant Hormone-Receptor Positive Breast Cance

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Jul 29, 2017 04:30AM 50sgirl wrote:

Babs, Thank you for starting this thread to document the steps you are taking as you prepare for the trial as well as your experiences once the trial begins. It sounds like you are busy already. I hope the treatments prove to be effective for you and others. It takes a special person to participate in a clinical trial, and I appreciate you and others who are doing it. I look forward to reading your updates. In the meantime, enjoy your trips.

Hugs and prayers, Lynne


Dx 6/5/2015, IDC, Left, 3cm, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- (FISH) Hormonal Therapy 6/25/2015 Arimidex (anastrozole) Dx 8/9/2016, IDC, Left, 3cm, Stage IV, metastasized to bone/liver, Grade 1, ER+/PR+, HER2- Hormonal Therapy 8/11/2016 Faslodex (fulvestrant) Targeted Therapy 8/31/2016 Ibrance (palbociclib)
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Jul 29, 2017 05:43AM illimae wrote:

Agreed. Thanks for the thread, I'll be following it and sending good vibes your way. Happy

Diagnosed at 41 Stage IV De Novo Dx 11/16/2016, IDC, Left, 5cm, Stage IV, metastasized to bone, Grade 3, 3/13 nodes, ER+/PR-, HER2+ (IHC) Targeted Therapy 1/1/2017 Perjeta (pertuzumab) Chemotherapy 1/2/2017 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 1/2/2017 Herceptin (trastuzumab) Surgery 6/26/2017 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Radiation Therapy 8/10/2017 Breast, Lymph nodes Dx 10/5/2017, IDC, Left, Stage IV, metastasized to brain Radiation Therapy 10/19/2017 External: Brain Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 29, 2017 07:12AM Cure-ious wrote:

Hi Babs,

We are here to cheer you on!! As we have discussed on earlier threads, the PI3K mutations are the most common mutation that crops up as breast cancer become resistant to any of various therapies. But the problem has been to get an inhibitor that works better and with far fewer side effects than a drug like Affinitor. Your trial will test a new PI3K alpha-subunit specific inhibitor, alone or with Ibrance-Femara.

I don't see much info out about this new drug, other than a short report that just came out last month:

A structure-, property-, and phenotype-guided strategy directed at high PI3K-isoform and PIKK-family selectivity, as well as a distinct cellular mechanism of action, culminated in the discovery of GDC-0077. Differences in primary and tertiary structure among PI3K isoforms were leveraged to achieve >300-fold selective inhibition of the PI3Kα isoform over the β, δ, and γ isoforms in biochemical assays. Very high selectivity over PIKK-family proteins such as mTOR, DNA-PK and VPS34 was also achieved through this process. In vitro and in vivo data indicate that GDC-0077 operates by a mechanism that promotes the selective degradation of "hotspot" p110α mutants (H1047R, E545K). Treatment of nude mice bearing PIK3CA-mutant breast tumor xenografts with oral GDC-0077 resulted in tumor regressions at well-tolerated doses. Together, the high degree of isoform selectivity, selective degradation of mutant-p110α, and in vivo PK/efficacy support the clinical evaluation of GDC-0077 as a treatment for patients with locally advanced or metastatic, PIK3CA-mutant cancer.

Basically, this drug is supposed to go in and degrade the mutant PI3K that is driving your cancer cell growth. As with all drugs, the cancer will eventually find a way to mutate some other protein and keep growing, however the stronger the drug, and hopefully the benefit of combining it with other drugs like Ibrance, will beat it back for a very long time. Best of luck and we are all with you!

Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
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Jul 29, 2017 07:32AM starbrightlyshines wrote:

Thank you for sharing Babs. I am at the point where my Dr says is the best time to be looking for trials, So I have been since spring but nothing has come up that I have been qualified for.  I am on month two of Kisquli, but even though its too early to see if its working, my tumor markers keep rising and I have had every side effect possible. (Ibrance was a dream, my Dr says this is similar but my body doesn't think so!)

I'll see if I have this mutation, I know my Foundation One report didn't come back with much that was "helpful" but I will have to investigate further.

Hugs

Hormonal Therapy 9/30/2012 Dx 10/2012, Stage IV, mets, ER+/PR+, HER2- Hormonal Therapy 6/3/2013 Femara (letrozole) Chemotherapy Gemzar (gemcitabine)
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Jul 29, 2017 08:20AM jensgotthis wrote:

Cheering you on and sending great hopes for the efficacy and tolerability of this trial for yo

Jennifer, 42, Los Angeles Dx 12/3/2015, IDC: Tubular, Left, 2cm, Stage IV, metastasized to bone, Grade 1, 0/12 nodes, ER+/PR+, HER2- Chemotherapy 1/5/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 5/1/2016 External: Bone Hormonal Therapy 5/23/2016 Surgery 5/25/2016 Lymph node removal: Left; Mastectomy: Left Targeted Therapy 9/14/2016 Ibrance (palbociclib) Hormonal Therapy 9/14/2016 Femara (letrozole) Radiation Therapy Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy
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Jul 30, 2017 05:36AM AnimalCrackers wrote:

Hi Babs, thanks for starting this thread and for participating in this trial. I'll be watching closely and cheering you on all the way!!

Cathy, diagnosed Stage IV de novo June 2014 (age 52). Bone mets at initial diagnosis (2014). Progression to Liver April 2017. Bisphosphonate infusions (Zometa) every 3 months. Clinical Trial 5/18/17 LSZ102 (oral SERD) and Kisqali (Ribociclib). Dx 6/23/2014, IDC, Left, 4cm, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 6/23/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/5/2016 Femara (letrozole) Targeted Therapy 1/5/2016 Ibrance (palbociclib) Dx 4/2017, IDC, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 5/18/2017 Targeted Therapy 5/18/2017 Kisqali
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Jul 31, 2017 09:18AM zarovka wrote:

following. cheering.

Z

PM me if you would like to join a BCO Stage IV FitBit Community. Dx 12/28/2015, IDC, Left, 4cm, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 1/17/2016 Femara (letrozole) Targeted Therapy 2/2/2016 Ibrance (palbociclib)
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Aug 1, 2017 10:03PM babs6287 wrote:

Hi

Waiting to be taken in for liver biopsy. The trial requires a fresh sample before starting the treatment and another one when a patient leaves the trial. This is my 3 rd liver biopsy!!!! Ugh!!!!

Bab

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 2, 2017 12:21AM 50sgirl wrote:

Ugh! I am sorry you have to go through yet another liver biopsy. Nine more days until the trial starts, right? I am keeping you in my thoughts and prayers.

Hugs, Lynne


Dx 6/5/2015, IDC, Left, 3cm, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- (FISH) Hormonal Therapy 6/25/2015 Arimidex (anastrozole) Dx 8/9/2016, IDC, Left, 3cm, Stage IV, metastasized to bone/liver, Grade 1, ER+/PR+, HER2- Hormonal Therapy 8/11/2016 Faslodex (fulvestrant) Targeted Therapy 8/31/2016 Ibrance (palbociclib)
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Aug 2, 2017 01:09AM babs6287 wrote:

So glad I did the biopsy. IR thinks I'm a great candidate for Y90 if the trial doesn't work. He contacted my MO about it That's a plus. !!

In recovery and I'm soooo hungry!

Bab

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 2, 2017 07:51AM - edited Aug 2, 2017 07:52AM by TarheelMichelle

hey Babs, I did a GDC trial last summer at MSKCC, in combination with Femara. I was fortunate to have a skin met, which is easier to biopsy twice, under the trial protocol. Unfortunately the dermatologist who did the biopsy created a huge scar directly under my left arm that's very visible now. A martyr for the cause. ;-)

I wish you the very best during the trial. Hope you feel fine and have good results.

Ronda - Extensive mets to lungs & bones. 9/13, subcutaneous skin mets. My life is Stage IV precious. Celebrating 6 years with Stage IV 12/2017. Ev Dx 2/14/2008, IDC, Left, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- Surgery 3/11/2008 Lumpectomy: Left; Lymph node removal: Left, Sentinel Radiation Therapy 4/17/2008 Dx 12/19/2011, Stage IV, metastasized to bone/lungs, mets, ER+/PR+, HER2- Hormonal Therapy 1/31/2012 Aromasin (exemestane) Hormonal Therapy 12/19/2012 Faslodex (fulvestrant) Hormonal Therapy 7/16/2013 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery 4/24/2014 Reconstruction (left) Radiation Therapy 11/21/2014 External: Bone Targeted Therapy 11/17/2015 Afinitor (everolimus) Targeted Therapy 5/20/2016 Hormonal Therapy 6/1/2016 Femara (letrozole) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Aug 2, 2017 08:32AM JFL wrote:

Good luck with the trial, Babs. And a candidate for Y90? That is excellent news!

Dx at 30. Dx with mets at 38 while pregnant. Extensive liver and bone involvement. Currently on Abraxane and XGeva. Dx 9/2006, IDC, Stage IIB, Grade 3, ER+/PR+, HER2- Surgery 9/22/2006 Mastectomy: Left, Right Chemotherapy 11/6/2006 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 3/15/2007 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 12/2014, IDC, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2- Chemotherapy 12/17/2014 Taxotere (docetaxel) Surgery 12/26/2014 Prophylactic ovary removal Hormonal Therapy 12/26/2014 Aromasin (exemestane), Faslodex (fulvestrant) Targeted Therapy 6/18/2015 Ibrance (palbociclib) Chemotherapy 3/10/2016 Xeloda (capecitabine) Hormonal Therapy 5/14/2017 Aromasin (exemestane) Targeted Therapy 5/14/2017 Afinitor (everolimus) Chemotherapy 8/18/2017 Abraxane (albumin-bound or nab-paclitaxel)
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Aug 2, 2017 12:48PM babs6287 wrote:

Hi Ronda. What was your experience in the trial? Was it for the sane mutation as this trial?

Bab

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 10, 2017 04:56PM babs6287 wrote:

Today's day 1 of trial. Will post at end of the day!

Babs

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 10, 2017 06:16PM 50sgirl wrote:

Hi Babs, Good luck. I am thinking about you. I can't wait to read about your experience on day 1.

Lynne

Dx 6/5/2015, IDC, Left, 3cm, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- (FISH) Hormonal Therapy 6/25/2015 Arimidex (anastrozole) Dx 8/9/2016, IDC, Left, 3cm, Stage IV, metastasized to bone/liver, Grade 1, ER+/PR+, HER2- Hormonal Therapy 8/11/2016 Faslodex (fulvestrant) Targeted Therapy 8/31/2016 Ibrance (palbociclib)
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Aug 10, 2017 06:28PM oriole wrote:

I will be thinking of you today, Babs! And, I look forward to following your progress. Hope today is a good day!

Oriole


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Aug 10, 2017 08:49PM AnimalCrackers wrote:

Hi Babs - thinking of you and wishing great success on this trial!

Cathy, diagnosed Stage IV de novo June 2014 (age 52). Bone mets at initial diagnosis (2014). Progression to Liver April 2017. Bisphosphonate infusions (Zometa) every 3 months. Clinical Trial 5/18/17 LSZ102 (oral SERD) and Kisqali (Ribociclib). Dx 6/23/2014, IDC, Left, 4cm, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 6/23/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/5/2016 Femara (letrozole) Targeted Therapy 1/5/2016 Ibrance (palbociclib) Dx 4/2017, IDC, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 5/18/2017 Targeted Therapy 5/18/2017 Kisqali
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Aug 11, 2017 01:54AM babs6287 wrote:

Thank you all!!!!

Here's hoping this study works-its a major time commitment. I still work FT hood thing I have a supportive boss!

Went to MSKCC without eating or drinking anything since the night before

8:30. Took weight, finger stick, EKG, temp and blood pressure

9:00 Met with my MO then study nurse. Took my GDC0077 and Letrozole at 9:48. Nurse went over all the protocol, gave me a diary to keep, and gave me a cold pack for the GDC0077. It must be refrigerated. Am not allowed to eat until 3 hrs after taking the meds.

1018. Must have many vials of blood taken about 1/2 hr after taking the pills. Of course my veins had an issue so I'm a little black and blue now. Also took temp and blood pressure.

11:48 ekg

12:48 temp blood pressure and lots more blood drawn

I can eat now. I was soooo hungry and thirsty. Lucky for me I live 1 1/2 blocks from Mskcc so I went home. I actually fell asleep! Guess I didn't sleep that well last night due to being anxious about today.

3:48 temp blood pressure and more blood taken. Glad the needle is finally out of my arm!

5:48 ekg. And all leads removed

Long day but unlike most I can go home in between so it's easier for me

Tomorrow I report at anywhere from 9:18-10:18. on an empty stomach again There is a 1/2 hr window before or after the initial time pills are taken for every part of the day

The worst part of the day for me was the blood draws. Even though they left everything in all day they did have trouble getting the blood to flow so they had to manipulate the needle. Ouch!!!

Will report on tomorrow!

Babs


Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 11, 2017 02:11AM 50sgirl wrote:

Wow, Babs, What a crazy day. You must be exhausted. It is a nice benefit to live close to the hospital. Relaxing at home is so much easier than relaxing in a hospital. The fact that you weren't allowed to drink for so long probably didn't help during the blood draws. A little hydration can work wonders. I hope you are able to sleep better tonight. Thank you so much for posting for us. As you know, we will all benefit from reading about your experience.

Hugs from, Lynne


Dx 6/5/2015, IDC, Left, 3cm, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- (FISH) Hormonal Therapy 6/25/2015 Arimidex (anastrozole) Dx 8/9/2016, IDC, Left, 3cm, Stage IV, metastasized to bone/liver, Grade 1, ER+/PR+, HER2- Hormonal Therapy 8/11/2016 Faslodex (fulvestrant) Targeted Therapy 8/31/2016 Ibrance (palbociclib)
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Aug 11, 2017 11:24PM babs6287 wrote:

2nd day of study

9:18 AM weight, glucose. blood pressure, temp and 2 vials of blood. EKG and then take the pills at 948. Can eat at 1048

Now I have to take the letrozole and GDC0077 every morning on an empty stomach I can eat 1 hour later. Before I go to Israel I have to have another liver biopsy for the study!

Babs

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 13, 2017 05:59AM zarovka wrote:

Go Babs!! Thanks for the detail. And doing the trial. A lot of work.

>Z<

PM me if you would like to join a BCO Stage IV FitBit Community. Dx 12/28/2015, IDC, Left, 4cm, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 1/17/2016 Femara (letrozole) Targeted Therapy 2/2/2016 Ibrance (palbociclib)
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Aug 16, 2017 05:05AM babs6287 wrote:

Just wanted to post an update.

The pills are real easy to take. But I do get a little queasy right after I do. Also, I'm no longer constipated-which is a good thing!

I have to have another liver biopsy this coming Monday as part of the study. It's supposed to be done when you've been taking the pills for 2 weeks but since I already had a trip to Israel planned for this coming Tuesday they made the decision to move it up so I could be a part of the study and still take my trip.

Will update as I have more to share!

Babs

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 18, 2017 10:20PM momallthetime wrote:

Babs just got to this treasure. I can't believe you have to get another biopsy and leave the next day. WOW! Interesting, so they can only see from the biopsy if something is working? Not scans? We'll keep checking on you. Thanks for this info.

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Aug 19, 2017 04:39PM babs6287 wrote:

Momall-They want to compare the cancer tissue from before the study, 2 weeks into and then again at the end. That's in addition to scans- that's really how they see if it's working.

Went yesterday for the study again-temp, blood pressure glucose, weight and 4 vials of blood and then meeting with the study nurses. Monday is the liver biopsy and then Tuesday another appointment- so much time for this!

Babs

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 21, 2017 10:17PM babs6287 wrote:

Today is another liver biopsy Waiting now to be taken.

Bab

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 22, 2017 01:27AM babs6287 wrote:

Biopsy is over. The hardest part was getting the IV in. IR had to do it via ultrasound. But I am fully black and blue yet again

Baba

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 23, 2017 02:23AM babs6287 wrote:

Today's visit they did glucose weight blood pressure, temperature oxygen level ekg and 9 vials of blood

Next saw mo nurse and study nurse.

All is good. Leaving for Israel for 2 weeks tonight

Bab

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 23, 2017 02:47AM AnimalCrackers wrote:

Have a great trip!  Try to take a vacation from cancer and not think about it!   

Cathy, diagnosed Stage IV de novo June 2014 (age 52). Bone mets at initial diagnosis (2014). Progression to Liver April 2017. Bisphosphonate infusions (Zometa) every 3 months. Clinical Trial 5/18/17 LSZ102 (oral SERD) and Kisqali (Ribociclib). Dx 6/23/2014, IDC, Left, 4cm, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 6/23/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/5/2016 Femara (letrozole) Targeted Therapy 1/5/2016 Ibrance (palbociclib) Dx 4/2017, IDC, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 5/18/2017 Targeted Therapy 5/18/2017 Kisqali
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Aug 23, 2017 03:21AM babs6287 wrote:

Animal Crack i intend to totally forget that I'm a cancer patient. My veins really need this rest too! Plus I want to enjoy every minute with my DD and SIL. How lucky am I that they want to spend their vacation with me!

Bab

Dx 8/17/2012, IDC, 4cm, Stage IIIC, Grade 2, 16/26 nodes, ER+/PR+, HER2- Surgery 8/24/2012 Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left Chemotherapy 9/21/2012 AC + T (Taxol) Radiation Therapy 1/21/2013 Breast, Lymph nodes Hormonal Therapy 3/22/2013 Aromasin (exemestane) Surgery 8/29/2013 Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 10/30/2013 Reconstruction (left) Surgery 1/28/2014 Reconstruction (left) Surgery 5/18/2014 Reconstruction (left) Surgery 10/17/2014 Reconstruction (left); Reconstruction (right) Dx 1/2015, IDC, Left, <1cm, Stage IV, metastasized to other, Grade 2, 16/26 nodes, ER+/PR+, HER2- (FISH) Hormonal Therapy 2/17/2015 Femara (letrozole) Targeted Therapy 3/14/2015 Ibrance (palbociclib) Dx 10/1/2015, IDC, Left, Stage IV, metastasized to bone/liver, Grade 2, 16/26 nodes, ER+/PR+, HER2- Targeted Therapy 10/24/2015 Chemotherapy 1/1/2016 Xeloda (capecitabine) Chemotherapy 10/6/2016 CMF Chemotherapy 12/9/2016 Taxol (paclitaxel) Chemotherapy 4/27/2017 Gemzar (gemcitabine) Chemotherapy 6/21/2017 Halaven (eribulin) Targeted Therapy 8/10/2017
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Aug 23, 2017 03:32AM AnimalCrackers wrote:

They are also the lucky ones!  They get to spend this time with you!  Have a wonderful time!  Wishing you nothing but joy!

Cathy, diagnosed Stage IV de novo June 2014 (age 52). Bone mets at initial diagnosis (2014). Progression to Liver April 2017. Bisphosphonate infusions (Zometa) every 3 months. Clinical Trial 5/18/17 LSZ102 (oral SERD) and Kisqali (Ribociclib). Dx 6/23/2014, IDC, Left, 4cm, Stage IV, metastasized to bone, mets, ER+/PR+, HER2- Hormonal Therapy 6/23/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/5/2016 Femara (letrozole) Targeted Therapy 1/5/2016 Ibrance (palbociclib) Dx 4/2017, IDC, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 5/18/2017 Targeted Therapy 5/18/2017 Kisqali

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