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Sep 10, 2018 10:05PM
It used to be that HER2+ was a bad thing. Times have changed. Herceptin came along and changed one's Overall Survival by several standard deviations. Now, it looks like immunotherapy will only truly work on TNBC and HER2+ as those tumors are what is called "hot". Even those of us with no over-expression of HER2 have enough HER2 to benefit from the CART therapies, as they've figured out canny ways to amplify the portion of the HER2 that they need to aim at. That's one of the trials I'm cleared to enter in - if I can afford the travel and out of network care. 18 visits in an 8 month period and a fairly big bag of procedures they want to do on their campus, not mine.
The only reason Judy Perkins got cured at that NIH trial is that while she had ER/PR+, HER2-, she had 67 somatic mutations, and one of the keys happened to fit in her lock. With the same pathology, I have 10. My homework tomorrow is to go through my Foundation One and the published Perkins mutations, and see if there is any overlap. Two other folk got "cured" as well, a bile duct cancer patient, and - I think - a colorectal patient. The Science article might have listed their mutations as well, but I can' remember.
Replace your sciatica, with my lactose intolerance, gluten intolerance and gallbladder issues. I'm getting tired of brown rice and mixed veg, with an egg. If I deviate at all, I'm in real pain RUQ, fatigued, and spend far too much time in the ladies' room. I'm learning how to handle it, but still make mistakes. I'm non-confrontational, but have learned to be that person at a restaurant. The last mistake landed me in the hospital for a night of fluids and pain management.
My SIL had sciatica with her last baby. She's small. her babies were big, and it just trashed her hips. I didn't have enough empathy at the time (had a bad case of young and stupid). As she puts it, it's like lightening ripping down your leg, and you can't get comfortable in any position. She couldn't take any meds because of the baby. I remember her moaning on the sofa, while trying to tend to two toddlers. Man, I need a time machine to go back and help more.
Ibrance/Femara messed up my liver too. I'd been bone only till that protocol.
We need to stay strong. Immunotherapy is showing real promise, not that "five years from now" promise we are so used to. If we are alive when it comes round the bend, we stand a chance of a durable remission, or at least more time without being on a chemo. There are also several articles I've read that postulate that while the immunotherapy might not kick cancer to the curb straightaway, it will increase the utility of the known chemotherapies, and it might even train the body - slowly - to react against cancer antibodies. All in all, more time for us.
Spouse has just chimed in to ask why you haven't done a cytoxic chemo as part of your late stage treatment? I let him ask these cheeky questions, because he is in the business.
Bedtime calls. Had navelbine today, so I will heed that call.
If it's not too invasive, can you talk to me about faith at some point? I had it, then left it. Sometimes I regret that, and other times my scientific secular humanism seems antithetical to faith. Heavy sigh.
ER/PR+, HER2-, Grade 3. Stage 4, July 2012. Currently on Navelbine
5/2006, IDC, 4cm, Stage IIB, Grade 3, 4/12 nodes, ER+/PR+, HER2-
3/2012, IDC, Stage IV, 4/12 nodes, ER+/PR+, HER2-
6/28/2012 Taxol (paclitaxel)
6/5/2013 Faslodex (fulvestrant)
7/1/2014 Xeloda (capecitabine)
8/14/2015 Femara (letrozole)
1/31/2016 Halaven (eribulin)
11/1/2016 Halaven (eribulin)