Topic: Lynparza/Olaparib Anyone?

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Feb 1, 2018 01:18AM - edited Feb 1, 2018 01:19AM by geekness

Posted on: Feb 1, 2018 01:18AM - edited Feb 1, 2018 01:19AM by geekness

geekness wrote:

I'm looking to share side effects or just any updates on Lynparza / Olaparib. I just started targeted therapy on Jan 12th. Aside from a little heartburn at first (helped with OTC pill), I've now started some daily Immodium, which the pharmacy sent WITH the Lynparza. Lol. I've started to just feel plain odd and very emotional. I can usually keep it together. I'm wondering if anyone else is yet on this medication. I'm Brca1 Stage 4 (Triple Negative) with mets to lungs and sacrum/soft tissue. I was doing gemzar/Carbo until December, which was keeping three small modules in lungs stable, but not helping anything in sacrum. So we switched it up and both insurance and pharm are helping me with copays on the meds, which I know I am very lucky to have had happen. It seems I can't find a big group yet that's taking this drug to compare how they might be feeling and I'd love to try and connect with a few people. I think even that might help me get right in my brain for a bit.

Chemotherapy 9/2/2015 AC + T (Taxotere) Dx 8/2017, IDC, Left, Stage IV, metastasized to bone/lungs, Grade 3, 0/15 nodes, ER-/PR-, HER2-
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Apr 21, 2022 11:04AM sondraf wrote:

Currently on 600 and felt absolutely fine (well, once I started taking the full dose!). This is about 3 or 4 weeks in to the 600.

Id been having indigestion troubles off and on with Ibrance but this is next level. The lansoprazole just got lost in the overall shuffle of everything in the last few months so I didn't think anything of it - it had been prescribed to go with the ibuprofen for pain management. I dont have the refill yet and called GP this morning to see if they had filled it but they can't find the actual prescription in my notes. *eye roll* At least that gives me tomorrow to get someone at the hospital to sort that out for me.

Its a bit better today, still points of uncomfortableness but hoping we are on the down slope here. Its utterly exhausting for sure!

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/28/2019 Femara (letrozole) Targeted Therapy 11/28/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.lynparza
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Apr 24, 2022 05:44PM sondraf wrote:

So it seems as though I caught either one hell of a gastro bug or that plus the lynpqrza combined created havoc. Or it was the super new Covid variant but none of my lateral flow tests were positive so who knows. Enough ibuprofen, senna, simethicone, clarityn, warm water, and rest and I'm almost back on track. Nurse will be calling tomorrow and I feel I could probably go back on treatment tomorrow night or Tuesday.

Missed our trip but I'm so happy to feel better compared to Friday and last week I'm not that bothered. And I was able to have a few sips of very nice champagne at our friends party this afternoon which no chance on the drugs! It was good to get out but thr fatigue tonight is quite a bit!

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/28/2019 Femara (letrozole) Targeted Therapy 11/28/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.lynparza
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Jul 1, 2022 02:34AM sondraf wrote:

Resurrecting this for a quick question. I was wondering if any other ladies on this drug had issues with dairy? I didn't think I was lactose intolerant, but lately Ive noticed nausea and fatigue (ilke, I need to sleep right now fatigue) about two hours after lunch, and that is when the horrible mouth taste also starts up. I don't have milk at breakfast as I don't eat cereal, but I usually have a small amount of yoghurt or cheese at lunch. Yesterday I had veggie sushi for lunch and no problems.... until I ate a bit of yoghurt at 4pm.

I take my pills at 7am and 7pm and checked the studies - peak blood concentration is before that afternoon window where I had been having problems.

Guess Ill try avoiding dairy for a few days - almond milk in the coffee this morning - and see what happens.

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/28/2019 Femara (letrozole) Targeted Therapy 11/28/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.lynparza
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Jul 1, 2022 09:05AM candy-678 wrote:

Sondra- I am a diary addict. I have milk every morning with breakfast-- cereal and a glass of milk to drink. And I LOVE cheese and think I eat quite a bit of it. I do have some nausea, but I was not attributing it to the dairy. My fatigue can be any time of the day, but I do take a 30-45 minute nap in the afternoons-- 2-3 hours after lunch. No mouth taste. I take my pills at 7a and 7p also.

Try avoiding dairy for a few days and report back here.

Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole) Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Targeted Therapy 9/1/2021 Targeted Therapy 9/1/2021 Targeted Therapy 9/1/2021 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.lynparza Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole), Zoladex (goserelin) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)
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4 hours ago star2017 wrote:

I haven't noticed any obvious connection with dairy,. I love cheeses, but try not to have too much bc it immediately leads to weight gain for me. My most consistent dairy is milk in my tea and occasionally a slice of cheese in a sandwich. No obvious nausea, but Ive read from other people taking it that dairy can be a trigger.

CURRENT: Stage IV since 2020, bone mets to rt hip, sacrum, femur, all treated with radiation. Taking Lynparza daily. Dx 9/2017, DCIS/IDC, Right, 6cm+, Stage IIIA, Grade 3, 4/8 nodes, ER+/PR+, HER2- Surgery 10/17/2017 Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Chemotherapy 11/29/2017 AC + T (Taxol) Surgery 4/18/2018 Prophylactic mastectomy; Prophylactic mastectomy (Left); Reconstruction (Left): Tissue Expander; Reconstruction (Right): Silicone implant Radiation Therapy 5/21/2018 Whole breast: Breast, Lymph nodes Surgery 10/24/2018 Reconstruction (Left): Silicone implant Hormonal Therapy 6/19/2019 Arimidex (anastrozole) Dx 5/2021, IDC, Right, 6cm+, Stage IV, metastasized to bone, ER+/PR+, HER2- Targeted Therapy Verzenio Radiation Therapy External Hormonal Therapy Faslodex (fulvestrant) Local Metastases Radiation therapy: Bone

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