Topic: Lynparza/Olaparib Anyone?

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Feb 1, 2018 01:18AM - edited Feb 1, 2018 01:19AM by geekness

Posted on: Feb 1, 2018 01:18AM - edited Feb 1, 2018 01:19AM by geekness

geekness wrote:

I'm looking to share side effects or just any updates on Lynparza / Olaparib. I just started targeted therapy on Jan 12th. Aside from a little heartburn at first (helped with OTC pill), I've now started some daily Immodium, which the pharmacy sent WITH the Lynparza. Lol. I've started to just feel plain odd and very emotional. I can usually keep it together. I'm wondering if anyone else is yet on this medication. I'm Brca1 Stage 4 (Triple Negative) with mets to lungs and sacrum/soft tissue. I was doing gemzar/Carbo until December, which was keeping three small modules in lungs stable, but not helping anything in sacrum. So we switched it up and both insurance and pharm are helping me with copays on the meds, which I know I am very lucky to have had happen. It seems I can't find a big group yet that's taking this drug to compare how they might be feeling and I'd love to try and connect with a few people. I think even that might help me get right in my brain for a bit.

Chemotherapy 9/2/2015 AC + T (Taxotere) Dx 8/2017, IDC, Left, Stage IV, metastasized to bone/lungs, Grade 3, 0/15 nodes, ER-/PR-, HER2-
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Nov 26, 2020 02:03PM hollyli1202 wrote:

Vidiot , great news that olaparib is working.

Maaaki, not sure about bone mets.

I am still around. 😊

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Dec 14, 2020 02:18AM ashlyn wrote:

Starting Lynparza (with Keytruda) this week as part of a trial.

Nice to see several doing well on this drug.

Have people experienced many side effects from the Lynparza? Nausea?

How frequently do you get labs done? And is it just the hemoglobin that drops? What of the neutrophils?

Ash

DX 28 - stage 2B ; DX 34 - stage 4 (lung, mediastinal nodes) DX: brain at 37 • 2018: PALB2+ Mutation A946_W1038del • RECQL VUS (A503V) likely patho Dx 1/3/2012, DCIS/IDC, Left, 2cm, Stage IIB, Grade 3, 1/12 nodes, ER+/PR+, HER2- Surgery 2/8/2012 Lymph node removal; Lymph node removal (Left); Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 4/3/2012 AC + T (Taxol) Radiation Therapy 9/10/2012 Whole breast: Breast, Lymph nodes Hormonal Therapy 11/2/2012 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 5/20/2014 Zoladex (goserelin) Hormonal Therapy 9/1/2014 Femara (letrozole) Hormonal Therapy 3/1/2016 Aromasin (exemestane) Dx 7/10/2017, IDC, Left, Stage IV, metastasized to lungs/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy 7/12/2017 Zoladex (goserelin) Hormonal Therapy 9/14/2017 Femara (letrozole) Radiation Therapy 9/21/2017 External: Lymph nodes Targeted Therapy 10/15/2017 Ibrance (palbociclib) Hormonal Therapy 11/13/2018 Faslodex (fulvestrant) Targeted Therapy 11/1/2019 Verzenio Chemotherapy 4/17/2020 Xeloda (capecitabine) Dx 9/2020, IDC, Stage IV, metastasized to brain, ER+ Radiation Therapy 10/23/2020 Radiation Therapy 11/3/2020 Immunotherapy 12/15/2020 Targeted Therapy 12/15/2020 Lynparza
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Aug 20, 2021 06:52PM candy-678 wrote:

Bump Thread---

I am going to be starting Lynparza as my 2nd line therapy.

I will go back and read this Thread.

Anyone out there on this currently???

April 2021 first progression and flip ER-/PR+ now. Current treatment as of Sept 2021 is Lynparza, Lupron (been on since Nov 2017), and Xgeva (been on since Nov 2017). Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Hormonal Therapy 11/1/2017 Femara (letrozole) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Lynparza (olaparib) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)
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Aug 21, 2021 03:04PM - edited Aug 21, 2021 03:15PM by ShetlandPony

Hi, candy. Just thought I would stop in and say Hi. My scans still show NEAD, but my onc and I have begun the what's next discussion because my tumor markers may be creeping up. At this point she is talking about a PARP inhibitor for me next because of somatic (tumor) mutations in the BRCA and related pathway. She indicated that is would be easier than Piqray, another option. Of course when the time comes we will do another Foundation One or Guardant 360, and I will have lots of questions.

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole breast: Breast Surgery Lumpectomy
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Sep 2, 2021 04:48PM candy-678 wrote:

Well I talked to my Palliative Care team yesterday (Zoom appointment). The doc prescribed Zofran in case I need it with starting Lynparza. I am to get the shipment of Lynparza tomorrow (Friday) and start it Saturday morning. I did a CBC today (Thursday) for a baseline reading. WBC 2.5 and ANC 1370 (1.3), being off Ibrance for 16 days now. Do they look at WBC's or ANC with Lynparza? I will have to read up on it. Will have to watch RBC's and platelets too with Lynparza I guess. RBC's 3.55 today and platelets today 270. On to the new med.

April 2021 first progression and flip ER-/PR+ now. Current treatment as of Sept 2021 is Lynparza, Lupron (been on since Nov 2017), and Xgeva (been on since Nov 2017). Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Hormonal Therapy 11/1/2017 Femara (letrozole) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Lynparza (olaparib) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)
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Sep 2, 2021 05:54PM - edited Sep 2, 2021 05:54PM by 2019whatayear

HI- I have been taking Lynparza since 7/18/2021. I got it approved for 1 year to reduce my risk of recurrence based on the OlympiA study. I am not stage 4, I hope that no one minds that I post here, I just wanted to share my experience with the drug in case it can help.

Candy drink LOTS of water. It's crucial! The first month was pretty rough, low grade nausea, major fatigue and I had constipation--many others have the opposite side effect. I didn't take zofran except 1x because that just compounds the constipation for me. Eat small meals often, drink lots of water (so important I had to share it twice). Many people take the med w/a spoonful of peanut butter. I use a spoonful sun nut butter.

My bloodwork didn't take a hit (knock on wood) There is a very active group on FB for ParP Inhibitors (many of the members are OvCa)

Some people have no side effects, some have had dose reductions. If you have any questions message me anytime.

The Pharmacy Nurses are great.

I have a pathogenic gBRCA 2 mutation

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020, Started Lynparza for 1 year preventative on 7/18/2021
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Sep 4, 2021 08:43AM candy-678 wrote:

Lynparza update--- Here we go. Took first dose just now. Was thinking.... with Ibrance we had a "welcome kit", lots of literature, the never ending commercials. With Lynparza--- Astra Zeneca-- no commercials, no welcome kit, just the bottle of meds. Not even fancy packaging. Just a bottle of 120 pills. Hum....

April 2021 first progression and flip ER-/PR+ now. Current treatment as of Sept 2021 is Lynparza, Lupron (been on since Nov 2017), and Xgeva (been on since Nov 2017). Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Hormonal Therapy 11/1/2017 Femara (letrozole) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Lynparza (olaparib) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)
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Sep 4, 2021 10:52AM ShetlandPony wrote:

Lol, candy. The xeloda folks sent me free lotion and the neratinib folks give me free immodium. Hey, Astra- Zeneca, where’s the swag? You are a brave hobbit. (Sometimes this is the image I use to encourage myself,).

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole breast: Breast Surgery Lumpectomy
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Sep 4, 2021 03:20PM 2019whatayear wrote:

I got a packet and lyparza fuzzy socks. I get mine thru Biologics by McKesson. If I get more socks I"m happy to send them to you! LOL I hope you are having a good low side effects day Candy678!

5/6/2019 IDC 2cm, micromet 1/9 nodes, BRCA2+, ER+, PR+, HER- BMX 6/2019, A/C & Taxol 2019, Radiation, BSO - preventative 2/2020, Letrozole 3/1/2020, Started Lynparza for 1 year preventative on 7/18/2021
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Sep 4, 2021 07:11PM candy-678 wrote:

2019whatayear---Hey I want fuzzy socks !!!! I used CVS Specialty Pharmacy--- my insurance. Well I took the first dose this morning with breakfast. Some nausea today, but I had nausea before the Lynparza too (have had nausea coming and going for quite a while-- during Ibrance use) so.... I did notice more saliva today. You know how when you are going to puke you mouth gets full of saliva. I have had increased saliva all day. Then waves of nausea. Like if I smelled something bad it wouldn't take much to hurl. Hum... I take 2nd dose in about an hour. I will take with crackers or something. See how dose #2 goes. I wonder about how it will go as time goes on. You said the first month is rough.

April 2021 first progression and flip ER-/PR+ now. Current treatment as of Sept 2021 is Lynparza, Lupron (been on since Nov 2017), and Xgeva (been on since Nov 2017). Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Hormonal Therapy 11/1/2017 Femara (letrozole) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Lynparza (olaparib) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)

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