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Topic: Intrathecal Herceptin plus Methotrexate?

Forum: Stage IV and Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Sep 18, 2018 10:58PM

hhfp wrote:

Anyone tried this combo for brain mets?

https://www.ncbi.nlm.nih.gov/pubmed/18690096

Abstract

Leptomeningeal carcinomatosis represents a rare manifestation of metastatic breast cancer (MBC). We herewith report on a patient suffering from HER2 overexpressing MBC who received intrathecal methotrexate and trastuzumab for meningeal carcinomatosis. A 48-year-old woman was diagnosed with breast cancer in December 2002. Following surgery, six cycles of adjuvant FE100C plus irradiation and, subsequently for 1 year, trastuzumab were given. As a result of disseminated metastatic spread in October 2005, the patient received whole-brain radiotherapy for symptomatic central nervous system involvement, and was put on several trastuzumab-based combination regimens (capecitabine, vinorelbine, paclitaxel). In June 2006, the patient developed clinical signs of terminal cone involvement with overflow incontinence and paraparesis of the legs. Immediate radiation led to partial relief from clinical symptoms. Subsequently, the patient was put on the tyrosine kinase inhibitor lapatinib and capecitabine (August to October 2007), but on November 6th the patient suffered again from overflow incontinence and weakness of the legs. Failing to respond to lapatinib, the patient received gemcitabine/cisplatin and, additionally, was recommenced on intravenous trastuzumab. Owing to progressive leptomeningeal disease, the patient received repeated doses of intrathecal methotrexate and trastuzumab. Within 2 weeks and four intrathecal treatments, cerebrospinal fluid cytology showed the absence of tumor cells. Moreover, a striking clinical improvement with resolution of the paraparesis of the legs and overflow incontinence was observed. This case report gives details regarding the clinical course of a breast cancer patient who received intrathecal trastuzumab and methotrexate via lumbar puncture for meningeal carcinomatosis of HER2-overexpressing MBC.

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Sep 21, 2018 01:51AM Daniel86 wrote:

Hey there

I know it might be a long shot but Becs posted about a treatment for some kind of brain cancer being used off label for breast cancer. You might look into it

https://community.breastcancer.org/forum/8/topics/777599?page=215

Daniel

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Sep 21, 2018 01:55AM hhfp wrote:

Yes, I saw that and took notes!

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Oct 18, 2018 02:15AM Ihopeg wrote:

Giving me hope!!! Thanks and hugs—— ilene
I Dx 11/11/2006, ILC, Right, 3cm, Stage IIIC, metastasized to bone, Grade 2, 19/20 nodes, ER+/PR+, HER2- Surgery 11/29/2006 Lymph node removal: Right, Sentinel, Underarm/Axillary; Mastectomy: Right; Prophylactic ovary removal Chemotherapy 1/7/2007 Chemotherapy 1/10/2007 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 5/30/2007 Breast, Lymph nodes Hormonal Therapy 8/19/2007 Femara (letrozole)
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Oct 22, 2018 11:21PM - edited Oct 22, 2018 11:29PM by hhfp

Could not get approval form insurance for Temodar as it is for brain cancers and tests for BC brain mets was inconclusive.

Also, read more on IT herceptin + methotrexate... works on cancer in CSF plus tiny mets <1mm... does not work on solid tumors.


Anyway, just started on IT herceptin + methotrexate + cytarabin to attack the cancer cells reachable by CSF

and Intravenous T-DM1... weakened blood brain barrier should allow T-DM1 to get to the BC brain mets.

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