Topic: Gemzar

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Jan 8, 2019 09:13PM

Posted on: Jan 8, 2019 09:13PM

dianalynn wrote:

is there anyone here on Gemzar? Had my first treatment on minday

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Feb 28, 2019 03:13PM dianalynn wrote:

thank you! We are trying a drug called navelbine on Monday

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Feb 28, 2019 03:31PM ABeautifulSunset wrote:

my doc has mentioned navelbine as a possible next. Just another chemo. May I ask, why did they keep you on Gemzar for 5 months if it wasnt working? My doc says if by my next bloody draw (in a couple of weeks before third cycle) my TMs are still rising he will take me off of it.

Sunset

“Sunsets are proof that endings can be beautiful too.” Radiation Therapy External: Breast, Chest wall, Bone Chemotherapy TAC Targeted Therapy Ibrance (palbociclib) Surgery Mastectomy; Reconstruction (left): Fat grafting, Silicone implant, Tissue expander placement; Reconstruction (right): Fat grafting, Silicone implant, Tissue expander placement Hormonal Therapy Aromasin (exemestane), Faslodex (fulvestrant), Femara (letrozole) Targeted Therapy Afinitor (everolimus) Targeted Therapy Chemotherapy Xeloda (capecitabine) Chemotherapy Doxil (liposomal doxorubicin) Chemotherapy Chemotherapy Targeted Therapy Targeted Therapy Afinitor (everolimus) Chemotherapy Xeloda (capecitabine) Chemotherapy Gemzar (gemcitabine)
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Feb 28, 2019 09:16PM dianalynn wrote:

no, five cycles. I should have said five treatments. I only started this drug in January and I knew pretty quickly it wasn’t working. Sorry for the confusion!

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Mar 1, 2019 04:46PM Mamita49 wrote:

Seven years ago, i was on Navalbine. Very successful.


small little liver buggers Dx 12/15/2008, IDC, 3cm, Grade 3, 2/7 nodes, ER+/PR+, HER2- Dx 12/2012, IDC, Stage IV, Grade 3, 0/0 nodes, mets, ER+/PR-, HER2-
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Mar 1, 2019 09:59PM dianalynn wrote:

that is good to know! I’ll take any positive news I can get!

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Mar 2, 2019 04:12AM Mamita49 wrote:

I have a question too. I had 8 cycles, 16 treatments. More than most women would have. I saw my Onc yesterday, and Scan is good. I had 2 small liver buggers, one gone now, and the remaining single one is too small to mesure. So.... Gemzar worked very well. He wants me to stop Chemo, and zip with radiation that small bugger, have a scan again and then put me back on Tamoxofin or Fermera.

Those anti-homonals did stop working for me 7 years ago, and now he wants me to get back again after 2 treatments of radiation. He said even if Gemzar is working well, I cannot put you on Chemo more than 8 cycles.

Scared about the anti-hormanals.

Any input please would be very appriciated

Carol


small little liver buggers Dx 12/15/2008, IDC, 3cm, Grade 3, 2/7 nodes, ER+/PR+, HER2- Dx 12/2012, IDC, Stage IV, Grade 3, 0/0 nodes, mets, ER+/PR-, HER2-
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Mar 2, 2019 08:19AM blainejennifer wrote:

Mamita,

Did your MO explain the reasoning behind limiting the Gemzar to eight cycles? I'm on Gemzar/Carboplatin now, and there has been no talk of eight cycles and out. It has been the usual "keep on going till it fails" scenario.

I'll be sure to ask MO what gives. It's working very well; my TMs are plummeting and I don't have pain anymore. That's the good part. The bad part is that it is really messing with my platelets (49!) and I have no energy at all. So, the thought of eight and out is somewhat seductive. They tried a platelet transfusion, and I had a very bad allergic reaction (couldn't breathe, large febrile reaction, etc.). MO says that he'll try again, if necessary, but I'll have to have a bunch of steroids on board, and be closely observed.

MO has talked about revisiting anti-hormonals that I had success with 6 years ago. For me, that's Faslodex. Now that my liver has cleared up, I might even be able to have it with one of its fancy new sidekicks. I would venture to guess that if it has been 7 years or more since you tried a regimen, there shouldn't be a problem with trying again. In the states, it might cause some insurance reimbursement problems. In Canada, do you have more leeway?

ER/PR+, HER2-, Grade 3. Stage 4, July 2012. Currently on Gemzar/Carboplatin Dx 5/2006, IDC, 4cm, Stage IIB, Grade 3, 4/12 nodes, ER+/PR+, HER2- Dx 3/2012, IDC, Stage IV, 4/12 nodes, ER+/PR+, HER2- Chemotherapy 6/27/2012 Taxol (paclitaxel) Hormonal Therapy 6/4/2013 Faslodex (fulvestrant) Chemotherapy 6/30/2014 Xeloda (capecitabine) Hormonal Therapy 8/14/2015 Femara (letrozole) Chemotherapy 1/31/2016 Halaven (eribulin) Chemotherapy 8/30/2016 CMF Chemotherapy 10/31/2016 Halaven (eribulin) Chemotherapy Carboplatin (Paraplatin), Gemzar (gemcitabine)
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Mar 2, 2019 08:32AM ABeautifulSunset wrote:

mamita,

what else have you been on for the past seven years?

“Sunsets are proof that endings can be beautiful too.” Radiation Therapy External: Breast, Chest wall, Bone Chemotherapy TAC Targeted Therapy Ibrance (palbociclib) Surgery Mastectomy; Reconstruction (left): Fat grafting, Silicone implant, Tissue expander placement; Reconstruction (right): Fat grafting, Silicone implant, Tissue expander placement Hormonal Therapy Aromasin (exemestane), Faslodex (fulvestrant), Femara (letrozole) Targeted Therapy Afinitor (everolimus) Targeted Therapy Chemotherapy Xeloda (capecitabine) Chemotherapy Doxil (liposomal doxorubicin) Chemotherapy Chemotherapy Targeted Therapy Targeted Therapy Afinitor (everolimus) Chemotherapy Xeloda (capecitabine) Chemotherapy Gemzar (gemcitabine)
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Mar 2, 2019 12:37PM Mamita49 wrote:

Almost 11 years ago, first time BC. Stage 2. Came back after 4 years. We have this " once a years bone scan and ultra sound policy" . Thank goodness, because I had two tiny liver buggers, so small, my TM where not even elevated. Doxil ( no good for me ) after Navalbine. It took the meds only 3 or four rounds, clear scan after a few weeks.

After that the cancer came back almost each year, no vital organs involved, 2 lymphnodes only each time. I was on almost each anti-homonal. From Tamoxofin, Femera, Amorasin, arimidex, Faslodex, Ibrance..... Lymphnodes clear, lymphnodes back...... After seven years again 2 mini tiny liver buggers. Doc thinks they are gone, since the remaining one was too small for the radiologist to mesure in January.

small little liver buggers Dx 12/15/2008, IDC, 3cm, Grade 3, 2/7 nodes, ER+/PR+, HER2- Dx 12/2012, IDC, Stage IV, Grade 3, 0/0 nodes, mets, ER+/PR-, HER2-
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Mar 2, 2019 12:51PM ABeautifulSunset wrote:

mamita, I feel like I've been on everything, as well. Although I do have a few more chemo options left. I'm also being tested to see if I have the right mutation for apselibib (sp?). I've historically had little or no mutations to target. If Gemzar/Cis works for a while, ONC says in about six months we'll radiate or Y90 anything left in the liver, then..don't know..maybe will try tamoxifen, as well. It's awesome you had 8 cycles of Gemzar. Keep us posted. Curious what you end up doing.


“Sunsets are proof that endings can be beautiful too.” Radiation Therapy External: Breast, Chest wall, Bone Chemotherapy TAC Targeted Therapy Ibrance (palbociclib) Surgery Mastectomy; Reconstruction (left): Fat grafting, Silicone implant, Tissue expander placement; Reconstruction (right): Fat grafting, Silicone implant, Tissue expander placement Hormonal Therapy Aromasin (exemestane), Faslodex (fulvestrant), Femara (letrozole) Targeted Therapy Afinitor (everolimus) Targeted Therapy Chemotherapy Xeloda (capecitabine) Chemotherapy Doxil (liposomal doxorubicin) Chemotherapy Chemotherapy Targeted Therapy Targeted Therapy Afinitor (everolimus) Chemotherapy Xeloda (capecitabine) Chemotherapy Gemzar (gemcitabine)

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