We are 222,154 members in 81 forums discussing 156,588 topics.

Help with Abbreviations

Topic: Ringworm drug for dogs (Fenbendazole) might also cure cancer

Forum: Stage IV/Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Apr 26, 2019 08:59PM

Chicagoan wrote:

This sounds kind of crazy but I'm tempted to try it, especially if standard treatments stop working:

https://www.dailymail.co.uk/health/article-6965325/Oklahoma-grandfather-claims-drug-DOGS-cured-cancer-tumor-free.html


Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/27/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/27/2016 Ibrance (palbociclib)
Log in to post a reply

Page 1 of 50 (1,494 results)

Posts 1 - 30 (1,494 total)

Log in to post a reply

Apr 26, 2019 09:26PM Chicagoan wrote:

If you are interested in reading more about this, here's a link to Joe Tippen's blog which explains more about his story and the doses that he took. He's still staying on it for maintenance. https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective

Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/27/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/27/2016 Ibrance (palbociclib)
Log in to post a reply

Apr 26, 2019 10:39PM JFL wrote:

Chicagoan, you should check out the Abemaciclib thread. Luce on that thread has mentioned this potential treatment (and may even be dabbling in it now). I am not on Abemaciclib but do follow the thread as there are some off-topic conversations about new potential treatments, research and alternative treatments.

Chart your own course. Dx at 30. Dx with mets at 38 while pregnant - extensive liver & bone involvement. Currently on Navelbine, Tamoxifen and XGeva. ER+/PR+, HER2 equivocal (IHC +2/FISH negative) as of most recent biopsy. Dx 9/2006, IDC, Right, 1cm, Stage IIB, Grade 3, 1/16 nodes, ER+/PR+, HER2- (FISH) Surgery 9/22/2006 Mastectomy: Left, Right Chemotherapy 11/6/2006 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 3/15/2007 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Dx 12/2014, IDC, Stage IV, metastasized to bone/liver/other, Grade 3, ER+/PR-, HER2- Surgery 12/26/2014 Prophylactic ovary removal Hormonal Therapy 12/26/2014 Aromasin (exemestane), Faslodex (fulvestrant) Targeted Therapy 6/18/2015 Ibrance (palbociclib) Chemotherapy 3/10/2016 Xeloda (capecitabine) Hormonal Therapy 5/14/2017 Aromasin (exemestane) Targeted Therapy 5/14/2017 Afinitor (everolimus) Chemotherapy 8/18/2017 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 3/23/2018 Doxil (doxorubicin) Chemotherapy 4/26/2019 Navelbine (vinorelbine) Hormonal Therapy 4/26/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Apr 27, 2019 05:57AM santabarbarian wrote:

mebendazole is another de wormer-- for people-- with anti-cancer properties...

pCR after neoadjuvant chemo w/ integrative practices Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/10/2019 Whole-breast: Breast, Lymph nodes
Log in to post a reply

Apr 27, 2019 06:50AM Chicagoan wrote:

JFL-Thanks, I will check out the Abemaciclib thread.

Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/27/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/27/2016 Ibrance (palbociclib)
Log in to post a reply

Apr 28, 2019 07:19AM - edited Apr 28, 2019 07:22AM by Frisky

Thank you Chicagoan for sharing this uplifting story. It sure sounds amazing.


Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 28, 2019 09:52AM - edited Apr 28, 2019 09:53AM by Cure-ious

This Post was deleted by Cure-ious.
Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 10:03AM - edited Apr 28, 2019 10:20AM by Cure-ious

Interestingly, mebendazole was found to be a strong TNIK kinase inhibitor and a potent inhibitor of the Wnt signaling pathway. Wnt signaling is normally only transiently active early during development, but is often reactivated to drive growth of very aggressive or late-stage cancers. Now available only by prescription.

https://www.nature.com/articles/srep33534

Like taxanes, it also blocks microtubule polarization. Fenbendazole is a closely related compound used for dogs.

Recent studies indicates it can function as a KRAS inhibitor. Remarkable activity given how few side effects these drugs seem to have, at least when taken in the short run:

https://www.ncbi.nlm.nih.gov/pubmed/30862488


Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 10:33AM - edited Apr 28, 2019 10:35AM by Frisky

cure-ious do you believe the protocol described is legitimate? That's not a scam?

It seems too good to be true, but so tempting....

I find it interesting that its very specific, down to the legitimacy of the well respected brand of supplements, except for the CBD oil.

I contacted the source and it's private which could lead to a potential money making scam....

What do you all think? Do you know of anyone that has succeeded on this protocol?

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 28, 2019 10:46AM - edited Apr 28, 2019 10:58AM by Leee

This Post was deleted by Leee.
Dx 8/2004, IDC, 1cm, Stage IIB, 0/2 nodes, ER+/PR-, HER2- (FISH) Dx 1/2018, IDC, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Chemotherapy 1/1/2019 Taxol (paclitaxel) Hormonal Therapy Faslodex (fulvestrant) Chemotherapy Adriamycin (doxorubicin), Cytoxan (cyclophosphamide) Hormonal Therapy Femara (letrozole), Zoladex (goserelin)
Log in to post a reply

Apr 28, 2019 10:59AM - edited Apr 28, 2019 11:03AM by Cure-ious

Miao,

The science is all over the place, but to me it seems very clear that these compounds should be regulated as bonafide drugs, they do have very potent anti-cancer activity on cultured cancer cells. I was just reading a paper where fenbendazole and mebendazole came up (along with all the chemo drugs we are very familiar with) in blind screens for compounds that can kill aggressive cancers in the lab. There are reports that these drugs inhibit glucose uptake and synergize with metformin, statins, COX-2 inhibitors, but the science right now is all over the map as to what these drugs are doing. Structurally, it looks like they ought to be kinase inhibitors. I am checking to see if they have been tested for effects on the immune system- for the patient discussed by Chicagoan above, he took the drug while he was on a clinical trial for late-stage lung cancer, and he was their best responder, so he presumes that the drug helped but it should be noted he wasn't taking it alone. He won't say what the trial was, but most likely it included immunotherapy, since it was his hail Mary clinical trial


So, remarkable is this is a oral pill with little in the way of daunting side effects, yet has chemo-like anti-cancer activity and is generic and off-patent. We need to know exactly what this is doing and what is the best combination to use it, whether with another drug or immunotherapy, etc. But cool to know there is another useful drug for metastatic cancers!


PS My darling Cocker-Schitzu dog had an aggressive anal gland cancer, had surgery and radiation and is pushing the year-and-a half timeperiod that the vets figure she'd have before the cancer comes back. So I'm definitely going to go out and pick up some fenbendazole for her!!

Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 11:08AM Frisky wrote:

cure-ious....my understanding is that he didn’t get that knowledge or results from a clinical trial. The protocol is something, someone he knew recommended and he tried it because he had nothing to lose...

Based on your understanding, then, the CBD oil ( the most expensive and private part of the protocol) might not be essential because the drug is the real agent...what does the CBD oil does? Isn’t it a just pain reliever?

Im way behind on the marijuana craze...

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 28, 2019 01:34PM - edited Apr 28, 2019 01:37PM by Cure-ious

Hey Miao,

If you read the Daily Mail article that Chicagoan posted at the top of this thread, you'll see that he took this drug (as a supplement) while he was on a clinical trial. Initially he didn't tell his doctor he was doing it, then eventually fessed up, after it was clear he was having an exceptional response and they decided to investigate why he responded so well. Because he had late-stage lung cancer, we can assume that his trial included at least one immunotherapy drug, maybe even an immuno combo.

It's as if doxil or navelbine had not yet been recognized to have anti-cancer properties, and you realized that you could take them on your own without a prescription, or having to worry about any serious side effects. But would you really want to use it that way? Luce says mebendazole is offered in a clinical trial at UCSD in combination with immunotherapy- suppose they find out that their protocol works great? if you take it now, you might not be eligible to get into a trial combining it with immunotherapy These compounds look like potentially powerful drugs, I wouldn't really be comfortable munching them like a supplement. I was surprised to find that some of the CDK9-type inhibitors can also be found off-prescription in the nutritional supplement stores, apparently bodybuilders have been using them for quite awhile.

UCSD is smart to offer mebendazole in a trial, because its off-patent and virtually none of their late-stage patients would have been exposed to the drug before. Plus, there are few side effects so it can be combined with immunotherapy, and what is known about the mechanism of action suggests the combo might work for a variety of cancers.

OTOH, this guy took them as a supplement, during his trial, and he lucked out. People do this kind of thing all the time. I doubt vitamins or CBD oil have any magical role in the combination, but who knows? If they work great, hopefully we'll hear about the trial from the UCSD folks sometime soon..

Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 01:50PM - edited Apr 28, 2019 01:50PM by Cure-ious

Having said all of that, now I don't see any clinical trial at UCSD that involves mebendazole, with or without immunotherapy.

Here is another example of someone who successfully played the odds with supplements:

https://www.telegraph.co.uk/lifestyle/wellbeing/he...


Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 01:54PM - edited Apr 28, 2019 02:01PM by Frisky

thanks Cure-ious I find your explanations extremely valuable....although, I must confess, I don't fully understand all the scientific correlations like you do, but I get the jest. You must be a professional in the field of medicine.

For most of my adult life—till I was diagnosed—I was taking only nature-thyroid, an ancient thyroid medication that most pharmacists have never heard of, eating macrobiotic and organic foods, seeing functional private doctors, and taking all sorts of supplements. Growing up in Italy I was an athlete and a semi-professional soccer player, and yet sometime next week I'll be taking Doxil and today got very excited about dog's parasite medications....life is strange.....as you can see,...I've come a long way....who knew it would end up this way? But that's the story for all of us....I’m sure each and every one of us is shocked and surprised to be this sick....

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 28, 2019 02:09PM Cure-ious wrote:

excellent video here:



Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 02:12PM - edited Apr 28, 2019 02:15PM by Cure-ious

This has been an interesting thread to read up on- there is an organization in the UK called Cancer Oncology Center that is treating patients with a combination of four drugs: metformin, statin, mebendazole, and the antibiotic, doxycycline. Apparently they cannot advertise but some of the patients who signed up have done well. No clinical trials, but they want to offer a supplement benefit using drugs like these that do not have a standard role in cancer therapy. And at least they know the standard dose to take. Keep in mind, these patients take this treatment as a supplement, in addition to the standard oncology treatments, not as a standalone treatment.

https://www.telegraph.co.uk/health-fitness/body/cr...

https://www.dailymail.co.uk/health/article-3115964...


Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 03:04PM - edited Apr 28, 2019 05:57PM by Frisky

Cure-ious....it's so funny because I'm already taking metformin, will be on Doxil soon, and amazon is shipping the canine anti parasitic medication and the supplements as we speak..

I figured: What do I have to lose? Will wait after the first infusion to start...

Contrary to the clinical trials available to me, and based on these anecdotal evidence, I really believe these combinations of things might get to the root cause and not just the symptoms....

I won't use the cbd oil because it's very expensive, I'm not in a lot of pain, and I'm not sure it plays an essential role...

I watched the video you posted, and continued to The Ted talks on the subject....one thing is certain: cancer cells are very smart, are capable of mutating and finding all sorts of pathway to the nutrients they need to survive....they are amazing resourcefulcreatures...sort of parasitic miniature Aliens that take over our bodies, in a slightly less dramatic fashion than in my favorite Hollywood movie....

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 28, 2019 03:57PM Cure-ious wrote:

How about the statin?! I'm a believer in that, it blocks a powerful oncogene called Yap1, could help a lot.

Good idea to wait and see how you respond to the Doxil alone first!

Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 28, 2019 05:12PM SchnauzerMom wrote:

I ordered the fenbendazole today also. I agree--it won't hurt, and it sounds promising. I started with Claritin several weeks ago largely because of the discussion on the Abemaciclib thread--thank you, Luce. (My only add-ons, and I am feeling pretty current for a little old lady!!)



mets to liver, bones Dx 11/21/1987, ILC, <1cm, Stage I, ER+/PR+, HER2- Dx 12/11/1989, ILC, Stage IIIA, mets, ER+/PR+, HER2- Chemotherapy 1/9/1990 CMF Hormonal Therapy 7/30/2012 Faslodex (fulvestrant) Hormonal Therapy 7/30/2012 Femara (letrozole) Dx 7/31/2012, ILC, Stage IV, mets, ER+/PR+ Targeted Therapy 1/14/2013 Avastin (bevacizumab) Chemotherapy 1/14/2013 Taxol (paclitaxel) Chemotherapy 11/9/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 4/1/2014 Navelbine (vinorelbine) Hormonal Therapy 7/22/2014 Aromasin (exemestane) Targeted Therapy 7/22/2014 Afinitor (everolimus) Chemotherapy 11/12/2014 Doxil (doxorubicin) Chemotherapy 7/12/2016 Xeloda (capecitabine) Chemotherapy 12/2/2016 Halaven (eribulin) Hormonal Therapy 5/31/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 7/17/2018 Verzenio
Log in to post a reply

Apr 28, 2019 05:50PM - edited Apr 28, 2019 05:58PM by Frisky

I guess i have to visit my wonderful primary physician and explain the situation....she's very sympathetic and has prescribed based on published medical research that I showed her a medication that was not FDA approved for that use, but that other well known doctors were using anyway.

Do statins have side effects I should be aware of?

Schnauzermom please keep us updated...We will need to share the results of our efforts to see if it's effective. What treatment are you undergoing currently?.

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 29, 2019 05:21AM - edited Apr 29, 2019 05:22AM by Frisky

cure-ious, is it true that Doxil is particularly hard on the bone marrow?

Considering that my metastasis are primarily in the bones, with a new small lesion in the liver, would doxil be a wise choice for me? Now that I have renewed hopes with the parasitic protocol, I would want to protect myself from the permanent damage of chemotherapy

What would you chose?

Thank you so much for your support, knowledge, and wisdom....

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 29, 2019 09:47AM SchnauzerMom wrote:

Miaomix,

I agree that we need to keep each other updated on our Fenbendazole experiences. My med should arrive today, so plan to start tomorrow. (I'm kind of excited, really. Not wagging my tail yet, though.) I'm taking 200mg of Verzenio since last July. Hope the meds play well together.



mets to liver, bones Dx 11/21/1987, ILC, <1cm, Stage I, ER+/PR+, HER2- Dx 12/11/1989, ILC, Stage IIIA, mets, ER+/PR+, HER2- Chemotherapy 1/9/1990 CMF Hormonal Therapy 7/30/2012 Faslodex (fulvestrant) Hormonal Therapy 7/30/2012 Femara (letrozole) Dx 7/31/2012, ILC, Stage IV, mets, ER+/PR+ Targeted Therapy 1/14/2013 Avastin (bevacizumab) Chemotherapy 1/14/2013 Taxol (paclitaxel) Chemotherapy 11/9/2013 Abraxane (albumin-bound or nab-paclitaxel) Chemotherapy 4/1/2014 Navelbine (vinorelbine) Hormonal Therapy 7/22/2014 Aromasin (exemestane) Targeted Therapy 7/22/2014 Afinitor (everolimus) Chemotherapy 11/12/2014 Doxil (doxorubicin) Chemotherapy 7/12/2016 Xeloda (capecitabine) Chemotherapy 12/2/2016 Halaven (eribulin) Hormonal Therapy 5/31/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 7/17/2018 Verzenio
Log in to post a reply

Apr 29, 2019 10:14AM Cure-ious wrote:

Miao, Definitely discuss whether statins are worthwhile with your primary!

Did you have any sequencing, for example for PI3K mutation or ESR1 mutation?


Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
Log in to post a reply

Apr 29, 2019 10:16AM Frisky wrote:

I reread Joe’s blog this morning, and it seems that this protocol works on different cancers, which means that it works with different cancer treatments.

I’m also veryhopeful and optimistic....happy to try and see what happens...

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 29, 2019 11:12AM - edited Apr 29, 2019 11:23AM by Frisky

Cure-ious, I know I had the ESR1 mutations and the AKT....I'm getting a liver biopsy on wed that will be genetically analyzed by MSK. When I asked my mo told me their analysis is better than Foundation 1....

I fear, I might end up getting Doxil before all the results are analyzed, since in reality the choices of chemotherapy are limited anyway. And the new ones have not been approved.

But, I would not want to start with Doxil if it suppresses or messes up bone marrow etc etc because my metastasis are primarily in the bones....the one in the liver is a novelty...

Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 29, 2019 11:36AM Chicagoan wrote:

Miao and Schnauzer,

Please keep us posted on how it goes. I'm not starting it yet-I've been stable on Ibrance, my first line treatment so I think I'll wait until I need to make a change. I am wondering if it will be effective on cancers that are fed primarily by hormones. I guess we'll find out. I appreciate all the discussion and insights from Cureious. It would be so great if this would work!

Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/27/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/27/2016 Ibrance (palbociclib)
Log in to post a reply

Apr 29, 2019 12:18PM - edited Apr 29, 2019 01:09PM by Frisky

yes Chicagoan....thank you for starting this tread....I was very saddened by the idea of starting IV chemotherapy—what I consider the beginning of the end—now instead i have something to look forward to. I have hope, although I still have to let myself be poisoned.

People that dismiss this information remind me of that scene in Jaws, where all the fishermen in small boats ignore the advice that the character played by Richard Dreyfus, gives them when he arrivesat the scene.

Because of the safety of the protocol described, I feel I have nothing to lose and a wholesome life to gain. I take numerous supplements anyway, the only medication I'm adding is the de-wormer.


Measure is All Dx 3/9/2015, ILC, Left, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Hormonal Therapy 3/15/2015 Femara (letrozole) Targeted Therapy 3/10/2017 Ibrance (palbociclib) Hormonal Therapy 3/10/2017 Faslodex (fulvestrant) Surgery 4/5/2017 Radiation Therapy 4/10/2017 External: Bone Hormonal Therapy 1/5/2018 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Targeted Therapy 2/10/2018 Afinitor (everolimus) Chemotherapy 6/2/2018 Xeloda (capecitabine)
Log in to post a reply

Apr 29, 2019 12:53PM Chico wrote:

I would like to second what Chicagoan says about hoping Miao & Schnauzer will keep us posted - good luck ladies. Also in thanking Cure-ious for sharing her research with us all.

I live in the U.K. and have considered contacting COC (Care Oncology Clinic) but again like Chicagoan I have been stable, with extensive bone mets, on I/L plus Xgeva since 2016, and would rather wait for things to change before adding more into the mix. I do have a friend on the protocol who is doing well however she did have problems with the very high dose of statins that she was prescribed.

My Onc suggested that taking a statin may be useful even though I don’t have particularly high cholesterol and this I have done. He also said it would be ok to add a low dose aspirin which so far I haven’t done.

Because I have a very high carb and sugar diet I may consider adding metformin sometime soon however my glucose levels are quite low. I will wait to ask my Onc after my next scan in July. I will then also ask if he thinks starting the worming tablet would be useful.



Log in to post a reply

Apr 29, 2019 01:04PM santabarbarian wrote:

I have zero diabetes issues and a good diet but am on Metformin after asking my MO about the benefits. i started on it around my first chemo. Despite no sleep issues, I take Melatonin 20mg every night (if you are not used to it, ramp up slowly to that dosage) for anti-cancer properties too.


pCR after neoadjuvant chemo w/ integrative practices Dx 7/13/2018, IDC, Left, 3cm, Stage IIB, Grade 3, ER-/PR-, HER2- (FISH) Chemotherapy 8/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/27/2018 Lumpectomy: Left Radiation Therapy 2/10/2019 Whole-breast: Breast, Lymph nodes
Log in to post a reply

Apr 29, 2019 01:19PM - edited Apr 29, 2019 01:19PM by mike3121

Do I order fenbendazole or mebendazole (MBZ) for my wife; she's interested.

My wife had a brief dance with NED and, because of a few mets of progression ( 2 in hips and 1 at T7), she dancing with Mr Eribulin again.

Page 1 of 50 (1,494 results)