Join Us

We are 219,563 members in 84 forums discussing 161,569 topics.

Help with Abbreviations

Topic: The HER2CLIMB-02 trial is enrolling!

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Metastatic breast cancer (MBC; also called stage IV) is breast cancer that has spread to other parts of the body, most commonly the bones, liver, brain, or lungs. Metastatic breast cancer can be treated but not cured. Metastatic disease is NOT hopeless. There are a wide variety of treatment options for metastatic breast cancer, and new medicines are being tested every day. More and more people are living life to the fullest while being treated for metastatic breast cancer.

Note: Please contact your doctor for any specific concerns about symptoms you are experiencing or your course of treatment.

Learn more about living with MBC.

Intro medically reviewed by: Brian Wojciechowski, M.D.
Last review date: November 22, 2020

Posted on: Jun 22, 2020 03:49PM

Moderators wrote:

The HER2CLIMB-02 trial is enrolling people diagnosed with advanced-stage HER2-positive breast cancer:

The HER2CLIMB-02 trial ( is looking to see if Tukysa (chemical name: tucatinib) given in combination with Kadcyla (chemical name: T-DM1 or ado-trastuzumab emtansine) will offer more benefits than Kadcyla alone in people diagnosed with:

  • metastatic HER2-positive breast cancer
  • locally-advanced HER2-positive disease that can't be completely removed with surgery
  • • a taxane chemotherapy, such as Taxotere (chemical name: docetaxel) or Taxol (chemical name: paclitaxel)
  • • Herceptin (chemical name: trastuzumab)

The HER2CLIMB-02 trial is being conducted at multiple sites around the world and the United States. For a complete list of sites, visit

For more information on detailed eligibility requirements or to enroll

Visit the You also may email or call 1-866-333-7436.

To send a Private Message to the Mods: