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All TopicsForum: HER2+ (Positive) Breast Cancer → Topic: HER2 3+ Pos, ER-, PR- What does this mean?

Topic: HER2 3+ Pos, ER-, PR- What does this mean?

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Jul 7, 2007 06:02AM

Courtney31 wrote:

I am 31 and had a bilateral mastectomy on June 20th. 2CM tumor in right breast no node involvement. I went to have my port put in yesterday and got the results back from the specimen that was sent out. I am very confused on this diagnosis. I meet with my oncologist on Monday but am wondering if anyone can explain it to me Thanks!

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Jul 7, 2007 06:30AM Dnicoletto wrote:

It means that your tumor is not positive for hormones, so you probably won't have to worry about hormone blocking drugs as part of your treatment.

Her2 +3 means that you have an oncogene that overexpresses and tells your cancer to grow fast. (Plus 3 tells it to grow really fast, making it more aggressive.) There is a drug that you will get to shut down the Her2 protein. It has very, very few side effects. I don't miss a beat when I get mine. I believe that 25% of all breast cancers are Her2+. I am no doc, but I hope that this helps.

Check the research section and read up on Her2. It is all here on this website.

~Dorie
Dx 3/10/2006, IDC, <1cm, Stage IIA, Grade 2, 2/10 nodes, mets, ER+/PR+, HER2+
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Jul 7, 2007 10:09AM Caya wrote:

Courtney - Yes, you are Her2neu+ - Her 2 is an oncogene (fancy word for cancer causing gene) that overexpresses Her2 - and about 25% of us BC women are Her2 neu+. There has been amazing results from the drug called Herceptin, basically after 4 years early stage BC patients (I am not a dr., but it sounds like you are stage 2a - which is considered early)there is about an 87% survival rate. The studies are only 4 years old because Herceptin was previously only given to Stage IV patients. My onc. told me that Herceptin has basically changed the whole outlook for Her2 neu+ cancer patients, from a "poorer prognosis" to a much better one.
So if you start looking up articles on the internet about Her2neu+ and Herceptin, make sure the articles are recent- 2005 and later. We are the pioneers of Herceptin, rewriting the stats everyday. Also node negative is huge - a very favourable prognostic factor.
all the best,
caya
Dx 10/16/2006, IDC, Right, 1cm, Grade 2, 0/16 nodes, ER+/PR+, HER2+ (FISH)
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Jul 7, 2007 09:03PM janie44 wrote:

Courtney,

Go to Treatment and Diagnosis at the top of this board and then click on Your Pathology Report on the left side. This explains everything about your diagnosis so very well.

As the other ladies have already said, your prognosis is so much better than it was just a few years ago since Herceptin came on the scene, and now Tykerb is the ace in the hole. Our prognosis literally went from poor to good overnight with the clinical trial results that made national news and caused oncologists to stand and cheer at their medical convention.

We all have different profiles because of so many factors, so we each have our own individual treatment mapped out depending on everything such as HER2 status, hormone status, etc.

Good luck and hugs,

Janie
Dx 3/11/2004, IDC, 3cm, Stage IIIA, Grade 3, 7/21 nodes, ER-/PR-, HER2+
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Aug 31, 2007 07:13AM bluewillow wrote:

Quote:

Courtney - Yes, you are Her2neu+ - Her 2 is an oncogene (fancy word for cancer causing gene) that overexpresses Her2 - and about 25% of us BC women are Her2 neu+. There has been amazing results from the drug called Herceptin, basically after 4 years early stage BC patients (I am not a dr., but it sounds like you are stage 2a - which is considered early)there is about an 87% survival rate. The studies are only 4 years old because Herceptin was previously only given to Stage IV patients. My onc. told me that Herceptin has basically changed the whole outlook for Her2 neu+ cancer patients, from a "poorer prognosis" to a much better one.
So if you start looking up articles on the internet about Her2neu+ and Herceptin, make sure the articles are recent- 2005 and later. We are the pioneers of Herceptin, rewriting the stats everyday. Also node negative is huge - a very favourable prognostic factor.
all the best,
caya




Hi Caya,
I thought I would jump in here and say that your post contained some of the most encouraging news and stats that I have ever seen on HER2 positive BC! I just noticed that you are in Canada, but do these stats apply to the United States also? I am so confused, because I have read where Stage 1 has about a 96 percent survival rate, but is that percentage lowered greatly by the presence of HER2 positive BC, even at Stage 1? If you could shed some more light on this for me, I would certainly appreciate it!

Thanks and best wishes,
Mary Jo
Nana of Mason, Hayden, and Addison~Lumpectomy, Re-excision, SNB, AC/Taxol, Radiation, 1 yr Herceptin Dx 7/26/2007, IDC, <1cm, Stage I, Grade 3, 0/4 nodes, ER-/PR-, HER2+
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Aug 31, 2007 09:36AM Steph54 wrote:

Hi Mary Jo,

Due to my Her2+++, my oncologist dropped the survival probability from 97% to 94%. These percentages were based on me taking an estrogen inhibitor for 5 years. The survival rate was then reduced by another 6% if I declined the Femara, putting it at 88%. ( Dx was Stage 1a so a little lower than your Stage 1 )
All of the above info came from consultation with 2 oncologists. Makes one's head spin, doesn't it?!

Sounds to me like you are heading in the right direction with your treatment plan. Chemo was not "in the cards" for me so unfortunately I wasn't able to have Herceptin.

Am so glad to see you receiving great response to your questions. This forum is a wonderful place to pour your heart out -- a safe haven during the storm. :>)

Take care,

Stephanie
Speth
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Aug 31, 2007 07:31PM bluewillow wrote:

Quote:

Hi Mary Jo,

Due to my Her2+++, my oncologist dropped the survival probability from 97% to 94%. These percentages were based on me taking an estrogen inhibitor for 5 years. The survival rate was then reduced by another 6% if I declined the Femara, putting it at 88%. ( Dx was Stage 1a so a little lower than your Stage 1 )
All of the above info came from consultation with 2 oncologists. Makes one's head spin, doesn't it?!

Sounds to me like you are heading in the right direction with your treatment plan. Chemo was not "in the cards" for me so unfortunately I wasn't able to have Herceptin.

Am so glad to see you receiving great response to your questions. This forum is a wonderful place to pour your heart out -- a safe haven during the storm. :>)

Take care,

Stephanie





Hi Stephanie and thanks so much for your information! Yes, all the stats are mind-boggling! But, those stats are still pretty darn great! As long as we have hope, then we can beat this thing! It has certainly taught me to enjoy each and every day and to worry about the things that count and forget the ones that don't.

Yes, I have received awesome support here - and to think I hesitated signing up at first. Again, thanks for all your help and my best to you!

Mary Jo
Nana of Mason, Hayden, and Addison~Lumpectomy, Re-excision, SNB, AC/Taxol, Radiation, 1 yr Herceptin Dx 7/26/2007, IDC, <1cm, Stage I, Grade 3, 0/4 nodes, ER-/PR-, HER2+
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Sep 9, 2007 12:26PM Caya wrote:

Hi Mary Jo,

 I just saw your post, and of course I am not a dr., but I can tell you what my onc. told me. He said that for me, I have some good prognostic features - I am ER+PR+ - which means I can take Tamoxifen, then an AI to futher reduce my risk of recurrence, my tumour was mucinous - very rare, about 2 - 3% of BC tumours, but good because it is less aggressive. Also I was node negative, a very favourable prognostic factor.   Even the Her2 neu+ now is being fought with Hercpetin, with excellent results.  I think the 87% survival rate was for early stages - which is considered stage 1 & 2.  I am stage 1, and my onc. says he is working on a "well over 90% cure rate " for me.  As I said previously, old stats for Her 2 are really old news - Herceptin is literally rewriting the stats for Her 2 women - especially early stagers.

My onc. would not use the word "cure" lightly - and these stats I believe are worldwide - I think it was from a big clinical trial in Europe - but the response to Herceptin has been revolutionary everywhere.

Good luck and all the best

caya

Dx 10/16/2006, IDC, Right, 1cm, Grade 2, 0/16 nodes, ER+/PR+, HER2+ (FISH)
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Mar 5, 2010 02:30PM - edited Mar 5, 2010 11:48PM by dja625

This Post was deleted by dja625.
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Mar 5, 2010 11:57PM - edited Mar 5, 2010 11:59PM by dja625

This Post was deleted by dja625.
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Mar 6, 2010 12:23AM dja625 wrote:

Hi Courtney,

I've deleted two replys to you because I am just as confused as you are. I know that everyone is different and your oncologist will look at everything about your case, including your age, size or tumor, grade, etc.. etc... I am going through a similar situation. I am scheduled for a bilateral mastectomy. I can't meet with my oncologist after the results come back for this next surgery. I've had two surgeries already.  My nodes were clear, but the margins weren't and they found more cancer. I didn't have a lump that anyone could feel. I went in for my routine mammogram. It started out as DCIS and when I had surgery it came back IDC, Her2 3+, Er- Pr-. I find this all so mind boggling. I recommend the Susan Love Breast Cancer Book. It is very informative, and can be able to guide through the process.

Hang in there,

Deb

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Feb 13, 2012 02:30AM barbiecorn wrote:

What does ER: 97% mean - This is on my pathology report - I am interested in what 97% means - Also PR:  0% - what does that mean - I know PR means progestrone but what about 0%???? 

Dx 12/26/2011, 2cm, Stage IIA, Grade 2, 0/0 nodes
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Feb 13, 2012 05:46AM Brenda_R wrote:

I just wanted to say that I was also Her2pos +3, ER-, PR-, stage 3 at presentation, and I am now 5 years out and still cancer free, thanks to Herceptin. I hope this may help you.

Dx 12/12/2006, IDC, 3cm, Stage IIIA, Grade 3, 1/17 nodes, ER-/PR-, HER2+ Surgery 12/29/2006 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Chemotherapy 1/28/2007 AC Radiation Therapy 5/1/2007 Breast Targeted Therapy 7/10/2007 Herceptin (trastuzumab)
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Feb 13, 2012 05:57AM lago wrote:

Courtney31 I am not doctor either but it does sound like since you are HER2+ and ER-/PR- you will probably be advised to do chemo with  herceptin. I'm guessing your grade 3 as well. Given your age I would also assume they want to treat  you aggressively.

The fact that we are node negative is a very good sign. Also, although you are ER-/PR-(and don't have hormone therapy as one of your guns) this may not be such a bad thing because if you get through the first 3 years your chances of distant recurrence goes way way down, With ER+PR+ our risk is much higher for recurrence. Granted there are no guarantees but that's how the statistics read.

Your oncologist will explain everything in detail. S/he will also give you statistics based on your path report and your age. Just remember when they give you a statistic based on 10 years that doesn't mean you only have 10 years to live. It's just that's how long they have statistics for. There is a woman in my building that is a 35 year survivor!

DONE!! alturl.com/3o9ni • Tattoos 2.7.2012 • Nipples 10.6.2011 • Exchange 6.24.2011 • Chemo 1.18. 2011 • BMX 8.31.2010 Dx 7/13/2010, IDC, 5cm, Stage IIB, Grade 3, 0/14 nodes, ER+/PR+, HER2+
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Feb 13, 2012 09:40AM bluedasher wrote:

BCIRG 006 tested to types of chemo with Herceoptin. TCH (Taxotere, Carboplatin and Herceptin) and AC-TH (Adriamycin, Cytoxan followed by Taxotere and Herceptin. There were a bit over 300 node negative women in each arm of the study so a pretty large group. They don't give statistics on the tumor size distribution for the node negative cases, but I think that they were only taking node negative >2cm (which would be Stage II)

5 year Disease Free Survival for the node negative was 90% (TCH) and 93% (AC-TH). So less than 10% had recurrences in the first 5 years and since HER2+ tumors are aggressive, recurrence tends to happen sooner if it is going to recur so longer term numbers probably don't change much. 

5-year overall survival was 96% and 97%. 

Based on that, survival should be a lot better than the 87% that Caya mentioned for Stage 2a. I'd expect something well above 90% with modern chemo and Herceptin.

Stephanie, did you have chemo and Herceptin? Since you are Stage 1a, I'm guessing that you didn't and your oncologists numbers only take hormone therapy into account.

The whole world is a narrow bridge and the main thing is to not fear. Dx 9/2008, IDC, <1cm, Stage IB, Grade 2, 0/5 nodes, ER-/PR-, HER2+ Targeted Therapy Herceptin (trastuzumab) Surgery Lumpectomy: Left Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy
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Feb 13, 2012 10:02AM lago wrote:

Bluedasher I know my 10 year NED/survival is 84% with chemo/hormone therapy at stage IIb. Now that doesn't include Herceptin so it's probably be even better. I think Caya might be about right with stage IIa but that doesn't consider Herceptin.
DONE!! alturl.com/3o9ni • Tattoos 2.7.2012 • Nipples 10.6.2011 • Exchange 6.24.2011 • Chemo 1.18. 2011 • BMX 8.31.2010 Dx 7/13/2010, IDC, 5cm, Stage IIB, Grade 3, 0/14 nodes, ER+/PR+, HER2+
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Nov 19, 2015 10:28AM sandcastle63 wrote:

Courtney,

I've just been diagnosed and agree it's mind numbing. I see the specialist in 2 days. I'm also a RN who happens to work as a hospice director so I typically see the bad days. That seems to be making this even harder for me. I am HER2 3+, ER-, PR-. I have not been given a stage as of yet just the stereotyptic biopsy which I'm not sure is accurate enough to give me node involvement. Original tumor size 4mm which is small. My KI67 was "high" 49%. Anyone know what that means???

sandcastle63 Dx 12/16/2015, IDC, Right, 2cm, Stage IIA, Grade 3, 0/1 nodes, ER+/PR+, HER2+ Surgery 12/16/2015 Lymph node removal: Sentinel; Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery 1/13/2016 Lymph node removal: Left, Right; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Nov 26, 2015 08:39AM Lweendo wrote:

hey all this information is very helpful to me as I am about to start chemo and had no idea what HER 2 meant

thanx

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Nov 26, 2015 08:46AM Lweendo wrote:

my results shoe HER2 +3 POS ER neg AND PR neg, I am now aware that this is more aggressive, does diet help reduce this aggression ive changed my diet completely to more healthy eating eg cutting out sugar more whole grains fruits and vegies no red meat?


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Nov 26, 2015 01:45PM Moderators wrote:

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Dec 25, 2015 12:18AM Gohan1983 wrote:

HER-2 positive cancer is recognized only when both hormone receptors are absent and HER-2 protein is overexpressed. It's particularly aggresive subtype of invasive breast cancer, however anti-HER-2 drugs far improved the prognosis. Luminal B (HER-2 positive) and HER-2 positive are two completely different subtypes with different gene alterations and clinical course. The most common histologic types which correspond with molecular HER-2 enriched subtype are ductal NOS and apocrine (include pleomorphic lobular cancer).

Dx 12/15/2013, IDC, Left, 6cm+, Stage IIIB, Grade 3, 1/19 nodes, ER+/PR+, HER2- Hormonal Therapy 12/17/2013 Femara (letrozole) Surgery 7/28/2014 Lymph node removal: Left; Mastectomy: Left Chemotherapy 10/1/2014 Taxol (paclitaxel) Hormonal Therapy 1/29/2015 Femara (letrozole) Radiation Therapy 2/5/2015 Whole-breast: Lymph nodes, Chest wall

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