Topic: ER-, PR-, Her2+ Roll call

Forum: HER2+ (Positive) Breast Cancer — Testing, treatment, side effects, and more.

Posted on: Apr 3, 2011 04:17AM

Posted on: Apr 3, 2011 04:17AM

nevo84 wrote:

Hello everyone

My mom was dx in November 2010. She is in her Chemo courses and only 2 sessions left. She is so well now and is very hopefull.My little niece makes her so happy and she is planning for the ceremony of her first birthday. Since she was dx I've explored in this site in different cathegories but sisters with this signature are few. So I decide to start a new thread in which we can call all   ER,PR-, HER+ gals and specially who survived for years. I hope we can make a group like triple positives and etc.

Dx 11/3/2010, IDC, 6cm+, Stage IIIA, Grade 3, 8/35 nodes, ER-/PR-, HER2+
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Mar 16, 2022 04:10PM mapmap79 wrote:

Beesy, Dutchiegirl, Melbo

Thank you guys for your sharing. Hugs.


Dx at 42. IDC, ER-PR-/HER2+, right breast, 3.1 cm, grade 3, at least 1 lymph node positive. Chemo TCHP 6 rounds. Right Mx. Right axillary node dissection. Radiation. Target therapy Herceptin.
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Mar 16, 2022 05:27PM - edited Mar 16, 2022 05:29PM by melbo

moth also posted a super hopeful article on another HER2+ Thread about just how good outcomes are now for HER2+ — calling it one of the most curable versions of BC. It is well worth a read.


https://community.breastcancer.org/forum/80/topics/825974?page=36#idx_1058


the link to the article: https://dailynews.ascopubs.org/do/10.1200/ADN.22.200872/full/

Diagnosed right before my 42nd birthday. One husband, two dogs, one cat and no kids. Dx 7/16/2020, IDC, Left, 2cm, Stage IIA, Grade 3, 1/7 nodes, ER-/PR-, HER2+ Targeted Therapy 8/7/2020 Herceptin (trastuzumab) Targeted Therapy 8/7/2020 Perjeta (pertuzumab) Chemotherapy 8/7/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/20/2020 Lumpectomy; Lumpectomy (Left); Lymph node removal; Reconstruction (Left); Reconstruction (Right) Radiation Therapy 1/31/2021 Whole breast: Breast, Lymph nodes
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Mar 16, 2022 07:27PM mapmap79 wrote:

Beesy, Dutchiegirl and Melbo,

Thank you guys for your sharing. I think I should move forward than worrying about things that already happened. Thanks again. Hug

Dx at 42. IDC, ER-PR-/HER2+, right breast, 3.1 cm, grade 3, at least 1 lymph node positive. Chemo TCHP 6 rounds. Right Mx. Right axillary node dissection. Radiation. Target therapy Herceptin.
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May 26, 2022 11:58PM sarahnh wrote:

Hi - Does anyone else here have super-high HER2 levels?

The reason I ask is, my FISH (HER2 to CEP-17) ratio is 16.1, and copy number (average # HER2 signals/cell) is 29.8.

I've read some articles which suggest that very high HER2 numbers tend to be herceptin-resistant, with decreased probability of PCR. The two oncologists I've seen (both great with great reputations) disagreed, and said they felt high HER2 numbers should have better-than-normal response to herceptin and odds for PCR.

Unfortunately I just had my post-chemo MRI, and it shows that my tumor is still at least 2 cm even after the full course of TCHP.

Has anyone else here had similar (or different!) experience with a high HER2 level?

Sarah



_________________

Diagnosis: Mixed IDC and ILC (with DCIS and LCIS). Right breast (5 cm). Right axillary lymph nodes (several up to 1 cm).
Pathology: ER negative (0%), PR negative (0%), HER2 positive. IHC 3+ (100% of cells). FISH positive (ratio 16.1). Grade 3.
Treatment: TCHP (Taxotere, Carboplatin, Phesgo).
(Putting this info here until the website is fixed) *** DIAGNOSIS:*** Mixed IDC and ILC (with DCIS and LCIS). Right breast (between 2.5 and 4.5 cm). Right axillary lymph nodes (at least 2). *** PATHOLOGY:*** ER negative (0%), PR negative (0%). HER2 positive. IHC 3+ (100% of cells). FISH positive (ratio 16.1). Grade 3. *** TREATMENT:*** TCHP (Taxotere, Carboplatin, Phesgo, with Neulasta Onpro) 6 cycles. Lumpectomy (4.5 cm) and targeted SLNB (7 nodes removed, 3 intentionally) (pathologic complete response) *** HOSPITALS:*** Dana Farber Cancer Institute. Massachusetts General Hospital.
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May 27, 2022 02:33AM bsandra wrote:

Dear Sarahnh, most probably high her2 ratios mean that disease is aggressive but not that it is her2-drug resistant. Might be that aggressiveness overcomes drug delivery rates. When you say full course of TCHP, you mean 8 cycles? Do you still have power to drop off carboplatin and continue with THP?

Saulius

Since May2021: NED. Mar2021: local axilla LN recurrence.Sep2019-Mar2021:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2- Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy; Mastectomy (Left) Radiation Therapy 9/9/2019 Whole breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal
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May 27, 2022 01:27PM sarahnh wrote:

Thanks Saulius - that is one of the speculations in the articles I read, that the aggressiveness may outweigh the drug effects. Or it may be a different type of cancer.

I did six cycles of TCHP. I will be getting Kadcyla (TDM-1) after surgery. Unfortunately it seems like doctors only stick with the standard protocols. They don't want to think about weird situations like mine. I will ask about THP.

I don't know anyone with numbers like mine -- and am hoping maybe someone here is in the same boat -- or at least might know of someone in the same boat.

Is there anyone out there?

-Sarah


_________________

Diagnosis: Mixed IDC and ILC (with DCIS and LCIS). Right breast (5 cm). Right axillary lymph nodes (several up to 1 cm).
Pathology: ER negative (0%), PR negative (0%), HER2 positive. IHC 3+ (100% of cells). FISH positive (ratio 16.1). Grade 3.
Treatment so far: TCHP (Taxotere, Carboplatin, Phesgo).


(Putting this info here until the website is fixed) *** DIAGNOSIS:*** Mixed IDC and ILC (with DCIS and LCIS). Right breast (between 2.5 and 4.5 cm). Right axillary lymph nodes (at least 2). *** PATHOLOGY:*** ER negative (0%), PR negative (0%). HER2 positive. IHC 3+ (100% of cells). FISH positive (ratio 16.1). Grade 3. *** TREATMENT:*** TCHP (Taxotere, Carboplatin, Phesgo, with Neulasta Onpro) 6 cycles. Lumpectomy (4.5 cm) and targeted SLNB (7 nodes removed, 3 intentionally) (pathologic complete response) *** HOSPITALS:*** Dana Farber Cancer Institute. Massachusetts General Hospital.
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May 27, 2022 03:02PM mcbaker wrote:

Sarah, I think you are n=1. Us hormone negative, HER+ are rare as it is. Very strong HER+ is rare among the rare. If "They don't want to think about weird situations like mine. ", then they are not good doctors. You might want to seek second opinions from the greatest of breast cancer treatment centers. If I were you, I would ask for aggressive treatment after surgery, especially since there is lymph node involvement. When I read that our kind of cancer likes brain tissue (and already knowing about the blood-brain barrier), I was eager to accept treatment which was aggressive given the small amount of cancer they found.

Mary Dx 10/3/2018, DCIS, Right, 6cm+, Stage 0, Grade 3, ER-/PR-, HER2+ Dx 11/16/2018, IDC, Right, <1, Stage IA, Grade 1, ER-/PR-, HER2+, IHC Surgery 11/16/2018 Lymph node removal; Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Targeted Therapy 12/19/2018 Herceptin (trastuzumab) Chemotherapy 12/19/2018 Taxol (paclitaxel) Chemotherapy 12/24/2018 Taxol (paclitaxel) Targeted Therapy 12/28/2018 Herceptin (trastuzumab) Surgery 6/28/2019 Reconstruction (Right): Fat grafting, Saline implant Chemotherapy
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May 28, 2022 07:05PM sarah_78 wrote:

From one Sarah to the other,

I have high HER2 and didn't receive PCR. i am getting Kadcyla as well. My onc said they removed all the cancer so with Kadcyla I should be fine. I also couldn't get radiation because I got it 10 years ago for Hodgkin.

I was wondering why TCHP didn't work on me as well as it was supposed to and found this article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC76790...

It is an interesting read. It is about different variants of HER2 protein and their sensitivity to chemo.

DIagnosed at 43, Hodgkin's Survivor (at 33) Chemotherapy 9/24/2021 Other Targeted Therapy 2/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 3/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Dx IDC/DCIS, Left, 5cm, Stage IIIA, Grade 3, 2/11 nodes, ER-/PR-, HER2+, IHC
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May 30, 2022 06:41PM sarahnh wrote:

Thanks Mary and Sarah!

I think/hope the two oncologists I've met with are both very good (Tolaney at Dana Farber is my oncologist, I also met with Isakoff at Massachusetts General), and both said the same thing about the high HER2. The plan is to get Kadcyla (TDM-1) after surgery, which is boilerplate for HER2 positive people who don't get PCR.

Sarah thank you for that paper, I hadn't seen it before. It's technical but I do have a math/science background so will spend some time on it. It is amazing how many tests could have been run on my biopsy, but were not. By the way, do you know what your HER2 numbers were (eg FISH ratio or?)

The other Sarah

(Putting this info here until the website is fixed) *** DIAGNOSIS:*** Mixed IDC and ILC (with DCIS and LCIS). Right breast (between 2.5 and 4.5 cm). Right axillary lymph nodes (at least 2). *** PATHOLOGY:*** ER negative (0%), PR negative (0%). HER2 positive. IHC 3+ (100% of cells). FISH positive (ratio 16.1). Grade 3. *** TREATMENT:*** TCHP (Taxotere, Carboplatin, Phesgo, with Neulasta Onpro) 6 cycles. Lumpectomy (4.5 cm) and targeted SLNB (7 nodes removed, 3 intentionally) (pathologic complete response) *** HOSPITALS:*** Dana Farber Cancer Institute. Massachusetts General Hospital.
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May 31, 2022 02:30AM bsandra wrote:

Dear Sarahnh, sorry for a late answer: I always forget you guys are earlier stages:/ Then yes, usually standard protocols... and that is 6 cycles of TCHP. I think you will be offered surgery with axillary lymph node dissection and adjuvant T-DM1 next for 1 year? You know... when Dr. Sara Tolaney is your MO you are in best hands in this, and she will do everything right.

Saulius

Since May2021: NED. Mar2021: local axilla LN recurrence.Sep2019-Mar2021:NED. Feb2019:local recurrence in left breast,IBC. May2018-Feb2019:NED. Jun2018:DC/CIK. Aug2017:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2- Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy; Mastectomy (Left) Radiation Therapy 9/9/2019 Whole breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal

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