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Topic: ATEMPT Clinical Trial - Roll Call

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

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Posted on: Nov 21, 2014 02:43PM - edited Feb 7, 2017 01:43PM by MaggieCat

MaggieCat wrote:

The ATEMPT clinical trial has been going on for several years.

Are you participating?

The recruiting period is over. The planned participant level of 500 has been met.

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/30/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/15/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Nov 4, 2017 11:07AM MaggieCat wrote:

http://ascopubs.org/doi/full/10.1200/JCO.2016.71.9815?utm_medium=cpc&utm_campaign=J_Clin_Oncol_TrendMD_0&utm_source=TrendMD


Thanks MI Pat! Here's the link to original report...

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/30/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/15/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Nov 4, 2017 11:22AM IsabelArcher wrote:

Thanks MIPat. Do you (or MaggieCat?) know how significant this study of neoadjuvant (preoperative) treatment is in relation to the adjuvant treatment we all had?

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Nov 4, 2017 11:54AM MaggieCat wrote:

Good question Isabel... I copied this from the full report....

"In 47 occurrences of pCR (40%), patients and physicians opted for no additional chemotherapy; survival follow-up in these patients will be documented and reported."

Members of this subset are as close a match to us as this trial has. After 3 cycles of T-DM1 they had no cancer left at the original tumor site. For us we had "no cancer left" after surgery and then had a number of cycles of T-DM1. We need to keep watch for updates...

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/30/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/15/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Jan 1, 2018 03:26PM TinyDancer5 wrote:

Wishing everyone a Happy and Healthy New Year!

Diagnosed at age 51. Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/19/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/9/2015 Whole-breast: Breast Hormonal Therapy 1/18/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/25/2016 Surgery 1/23/2020 Prophylactic ovary removal Hormonal Therapy 2/25/2020 Arimidex (anastrozole)
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Jan 1, 2018 04:36PM MaggieCat wrote:

May 2o18 be our best! Broken wrist - fall in a manner that "explains" - honestly think my Xmas during treatment was easier! Ready to wash my hair again!!!!

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/30/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/15/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Jan 1, 2018 04:44PM Reikion wrote:

Wishing everyone a happy, healthy and peaceful new year!

MaggiCat, hope your wrist heals soon!


Dx 12/10/2015, DCIS/IDC, Left, <1cm, Stage IA, Grade 2, 0/1 nodes, ER-/PR-, HER2+ (FISH) Surgery 2/21/2016 Lumpectomy: Left; Lymph node removal: Sentinel; Reconstruction (left); Reconstruction (right) Targeted Therapy 5/20/2016 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 8/16/2016 Whole-breast: Breast
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Jan 3, 2018 08:22PM Serenitysis wrote:

Happy and HEALTHY 2018!! Hope everyone is doing well.

Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Jan 8, 2018 11:50AM IsabelArcher wrote:

Hi ladies, happy new year to all! I have my 6-month appt. at Dana Farber this Wednesday. This is the "easy" one with no scheduled mammo, just an exam with the PA. It will mark 4.5 years...

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jan 9, 2018 01:01PM wabals wrote:

Hi Isabel Archer!

You are not taking hormones therapy are you

Dx 6/2015, IDC, Left, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ (FISH) Hormonal Therapy Radiation Therapy Surgery Lumpectomy: Left Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Jan 11, 2018 11:43AM IsabelArcher wrote:

Hi Wabals-- I take tamoxifen. I switched to Arimidex briefly last spring, but had a bad experience with it, so switched back to Tamox. I have no problems with it. Yesterday's appointment was exactly what I hoped for--in and out, not much to talk about, exam fine.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jan 11, 2018 10:04PM TinyDancer5 wrote:

Isabel, congrats on your fine exam. I too am on Tamoxifen.

Diagnosed at age 51. Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/19/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/9/2015 Whole-breast: Breast Hormonal Therapy 1/18/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/25/2016 Surgery 1/23/2020 Prophylactic ovary removal Hormonal Therapy 2/25/2020 Arimidex (anastrozole)
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Jan 19, 2018 11:55AM IsabelArcher wrote:

Hi all. I hope none of us ever needs this, but it's good to know researchers continue to test promising new drugs for advanced HER2. This article was in the Dana Farber newsletter on women's cancers.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Mar 21, 2018 01:54PM MIPat wrote:

So, today was my annual mammogram, 2 years after the one that showed the breast cancer. I needed two more images on both sides. The left was clear, but they found microcalcifications on the right which is my surgical side. While the radiologist said that they were more than likely benign, because of my history I now have to have a stereotactic breast biopsy of the area. Needless to say, I am not a happy person right now. I am praying that it is nothing serious since they can be related to the radiation and necrosis of fat.

Dx 5/31/2016, IDC, Right, 1cm, Stage IA, Grade 2, ER-/PR-, HER2+ (IHC) Surgery 5/31/2016 Lumpectomy: Right Dx 6/23/2016, DCIS, Right, Stage 0, 0/1 nodes Surgery 6/23/2016 Lumpectomy: Right; Lymph node removal: Sentinel Targeted Therapy 8/1/2016 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 1/17/2017 Herceptin (trastuzumab)
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Mar 22, 2018 10:32AM IsabelArcher wrote:

MIPat--UGH. It's sickening that you have to go through this. Repeat the mantra: it's probably nothing. Because most things ARE nothing. Decide on what present you want to give yourself when this is over. Not much activity on this thread for the last few weeks, but I do check it every day--please post results. Thinking of you and pulling for you. (And CURSING.)

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Mar 23, 2018 03:43PM MIPat wrote:

Thank you IsabelArcher, you got me to laugh

Dx 5/31/2016, IDC, Right, 1cm, Stage IA, Grade 2, ER-/PR-, HER2+ (IHC) Surgery 5/31/2016 Lumpectomy: Right Dx 6/23/2016, DCIS, Right, Stage 0, 0/1 nodes Surgery 6/23/2016 Lumpectomy: Right; Lymph node removal: Sentinel Targeted Therapy 8/1/2016 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 1/17/2017 Herceptin (trastuzumab)
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Mar 24, 2018 12:00PM MaggieCat wrote:

MIPat - I agree with IsabelArcher - it's probably nothing! Fingers crossed ... Will watch for your update... Maggie

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/30/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/15/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Mar 31, 2018 11:20PM Ozoner wrote:

Hi MIPat--hoping you get good news pronto! I'm somewhat edgy because I will have my three-year testing this month. Waiting is the worst part, but waiting when you've been through what we have is really hard.

Years ago microcalcifications rarely caused a stir, but at least we get world-class care in an over abundance of caution.

Will watch for your post, hopefully soon!

Dx 3/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR-, HER2+ Surgery 3/9/2015 Lumpectomy: Left Radiation Therapy Whole-breast: Breast Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab) Hormonal Therapy Aromasin (exemestane), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Chemotherapy Other
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Apr 2, 2018 06:38AM Serenitysis wrote:

Hi MIPat, so sorry to hear about your having to go through this! I’ll be thinking of you. I have my mammogram and follow-up appointment tomorrow, Tuesday, 3 years from diagnosis. I can’t believe it’s been that long. Feeling a bit anxious...

Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Apr 5, 2018 06:28PM Serenitysis wrote:

Hi all, just reporting that my mammogram (½ mammo in my case!) was normal. Whew! A mammogram will never again feel routine.

I asked my study nurse about the trial results. She said it will likely be a couple of years before the final results are out, as of course the follow-up with patients is a necessary part. She said she thought some patients were just finishing treatment.

My best to all, and happy spring!


Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Apr 6, 2018 10:30AM IsabelArcher wrote:

Great news, SerenitySis! My 1/2 mammo is in July--it will be the all-important 5-yr mark for me, so I expect the anxiety to be even worse than other years. Here in the Northeast spring still seems far away, but it has to come at some point!

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Apr 6, 2018 07:51PM Serenitysis wrote:

Thanks, IsabelArcher, you are 2 years ahead of me! I had a long wait in the waiting room for my results, everyone else there had come & gone, so I started getting really nervous. They were just slow.

I am also in the northeast, so I know what you mean!




Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Apr 10, 2018 01:53PM MIPat wrote:

A huge sigh of relief. A day later than promised I received my results. The microcalcifications turned out to be fat necrosis most likely a result of radiation treatment. I have to have a follow up mammogram in 6 months. The stereotactic biopsy wasn’t as awful as I expected, but then again with everything that we have to go through it is all relative. After getting all set up, they questioned the depth that the computer was saying the calcifications were at and I had to go for additional mammogram films before restarting the entire thing. I do feel like I have been through the emotional ringer on this one.

Thank you to everyone for your words of support.

Serentiysis glad that you had negative films. You are correct. Long gone are the days where we would say “oh, I have my mammogram next week” Part of that new norm

Dx 5/31/2016, IDC, Right, 1cm, Stage IA, Grade 2, ER-/PR-, HER2+ (IHC) Surgery 5/31/2016 Lumpectomy: Right Dx 6/23/2016, DCIS, Right, Stage 0, 0/1 nodes Surgery 6/23/2016 Lumpectomy: Right; Lymph node removal: Sentinel Targeted Therapy 8/1/2016 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 1/17/2017 Herceptin (trastuzumab)
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Apr 10, 2018 02:53PM IsabelArcher wrote:

MIPat, I am so happy to hear this. Phew! As for the stereotactic biopsy, I had a bad experience with it 5 yrs ago--unusual, and weird. But yes, everything is relative... At the same time that the anxiety tears us up, we have become strong and resilient in ways we didn't know were possible, right?

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Apr 14, 2018 07:43AM Serenitysis wrote:

MIPat, congratulations on your good news! Sorry you had to go through so much to get it.



Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Apr 14, 2018 07:44PM TinyDancer5 wrote:

MIPat, I'm happy to hear your good news!

Diagnosed at age 51. Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/19/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/9/2015 Whole-breast: Breast Hormonal Therapy 1/18/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/25/2016 Surgery 1/23/2020 Prophylactic ovary removal Hormonal Therapy 2/25/2020 Arimidex (anastrozole)
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Apr 16, 2018 12:31PM Ozoner wrote:

Hi MIPat!

So happy for your great news! My tomography images were good as well. Let's all celebrate!

Dx 3/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR-, HER2+ Surgery 3/9/2015 Lumpectomy: Left Radiation Therapy Whole-breast: Breast Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab) Hormonal Therapy Aromasin (exemestane), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Chemotherapy Other
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May 17, 2018 11:30AM IsabelArcher wrote:

Hello, ladies. Interesting news about Herceptin--a study in the UK found that it can be given for 6 months with the same benefits as 1 year. When I was on the TDM1 trial, and had to stop early because of low platelet count (but continued on Herceptin alone), my onc said the decision to set the TDM1 treatment for a year was just researchers' best guess and based on the Herceptin year. So this news about Herceptin could have implications for TDM1 in the future.

https://www.nytimes.com/2018/05/16/health/breast-cancer-herceptin-genentech.html

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/9/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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May 23, 2018 03:57PM Serenitysis wrote:

Hi IsabelA, I really appreciate your posting. I wish I could have done the whole treatment in 6 mos. I'm positive I would have had fewer side effects, avoided the significant fatigue that got worse over time, and not lost so much weight. Well, that's why many of us did the trial, so that options could open up for the women coming after us.

So great to have it all behind us. I hope everyone is doing well!





Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Jul 1, 2018 03:23PM TinyDancer5 wrote:

Does anyone have one of those "cooling" pillows that are supposed to keep you cool at night? If yes, does it work and which one do you have

Diagnosed at age 51. Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/19/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/9/2015 Whole-breast: Breast Hormonal Therapy 1/18/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/25/2016 Surgery 1/23/2020 Prophylactic ovary removal Hormonal Therapy 2/25/2020 Arimidex (anastrozole)
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Jul 1, 2018 07:44PM BellasMomToo wrote:

TinyDancer: I have a cooling pillow. It doesn't work very well. When you first put your head on the pillow, it's cool. But it warms up quickly. I often wake up in the middle of the night cause my head is too warm -- I turn the pillow to a cool side and go back to sleep. I bought mine at Costco. Since it was cheap (less than $20) I thought I would give it a try.

Dx'd at age 56. Tumor found by my annual mammogram -- cancer can grow fast! Dx 10/6/2016, IDC, Left, 2cm, Grade 2, 0/1 nodes, ER-/PR-, HER2+ (IHC) Dx 10/6/2016, DCIS, Left, Stage 0, ER+/PR- Targeted Therapy 11/1/2016 Herceptin (trastuzumab) Chemotherapy 11/1/2016 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 11/1/2016 Perjeta (pertuzumab) Surgery 3/27/2017 Lymph node removal: Sentinel; Mastectomy: Left

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