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Topic: ATEMPT Clinical Trial - Roll Call

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Nov 21, 2014 02:43PM - edited Feb 7, 2017 01:43PM by MaggieCat

MaggieCat wrote:

The ATEMPT clinical trial has been going on for several years.

Are you participating?

The recruiting period is over. The planned participant level of 500 has been met.

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/31/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/16/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Nov 11, 2018 12:55PM wabals wrote:

I also had liver enzyme elevation but not high enough to take me off

Dx 6/2015, IDC, Left, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ (FISH) Hormonal Therapy Radiation Therapy Surgery Lumpectomy: Left Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Jan 1, 2019 05:59PM TinyDancer5 wrote:

Wishing everyone a happy and healthy new year!

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Jan 2, 2019 10:03PM TTfan wrote:

thanks dancer, happy new year to you and all our crew. May 2019 be filled with joy and good health

Dx 9/21/2014, IDC, <1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2+ Surgery 10/9/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/2/2014 Herceptin (trastuzumab) Chemotherapy 12/2/2014 Taxol (paclitaxel) Radiation Therapy 3/23/2015 Whole-breast: Breast Hormonal Therapy 4/27/2015 Arimidex (anastrozole) Hormonal Therapy 3/1/2016 Aromasin (exemestane) Hormonal Therapy 8/7/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 4, 2019 06:25AM Serenitysis wrote:

Happy New Year, everyone! I hope you’re all feeling great in 2019. It’s nice to put cancer even further behind us.

Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Jan 4, 2019 08:02AM MaggieCat wrote:


https://www.practiceupdate.com/content/adjuvant-t-dm1-for-her-2-breast-cancer-critical-data-from-the-katherine-study/77201/55/1/3

The Katherine trial is first to report excellent results with adjuvant T-DM1 for early BC... nice way to end 2018 and start 2019!

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/31/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/16/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Jan 7, 2019 11:12AM IsabelArcher wrote:

MaggieCat, thanks for posting this. The link required a subscription/membership but I googled it and was able to read a report elsewhere. The study was of women with early BC but who had "residual disease," either in the breast or lymph nodes, after neoadjuvant chemo plus surgery. I'm confused by this. 1) do you know why women with early BC would be given chemo before surgery? I thought that was for situations where a tumor needs to be shrunk--but early-stage tumors are small. 2) if there's residual cancer after surgery, wouldn't further surgery be called for? Any clarifications you might be able to give would be welcome.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jan 7, 2019 12:13PM MaggieCat wrote:

Here's a summary from the ASCO with more info.... Neoadjuvant treatment followed by surgery is a more broadly available treatment for early stage BC than 4 or 5 years ago. The residual disease was found in the tissue removed during surgery.....so no known cancer remains.


The phase III KATHERINE clinical trial compared the use of ado-trastuzumab emtansine (T-DM1; Kadcyla) vs trastuzumab (Herceptin) as adjuvant therapy in patients with HER2-positive early-stage breast cancer with residual invasive disease after receiving neoadjuvant chemotherapy and trastuzumab. The study showed that T-DM1 reduced the risk of developing an invasive recurrence or death by 50%. Secondary efficacy endpoints of disease-free survival and distant recurrence–free interval also demonstrated clinically meaningful improvements with T-DMI.

Clinical Significance

"We found that T-DM1 reduced the risk of developing an invasive recurrence of the breast cancer or death by 50%, corresponding to an absolute improvement of 3-year invasive disease–free survival rate by 11.3 percentage points (77% with trastuzumab and 88.3% with T-DM1)," said Charles E. Geyer, Jr, MD, Professor of Medicine at Virginia Commonwealth University School of Medicine and lead author of this study, in a statement. "I believe these results will be practice-changing. The results should form the foundation of a new standard of care in patients with residual invasive breast cancer following neoadjuvant therapy. KATHERINE demonstrates that neoadjuvant therapy can be used to identify patients at increased risk for recurrence based on less than optimal response to standard neoadjuvant therapies who can benefit by switching to T-DM1."

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/31/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/16/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Jan 8, 2019 11:21AM IsabelArcher wrote:

MaggieCat-- Thanks--I think I understand now. The patient has chemo, then surgery, and if there's cancer in the removed tissue at that point, it's called residual. And the trial tested adjuvant TDM1 v. Herceptin. Is that right?

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jan 11, 2019 09:21PM TinyDancer5 wrote:

Hello Ladies, I have been having...overactive bladder or sensitive bladder issues for a while now. It doesn't matter how much I drink either. I will see my MO on Feb 1st, for a check up and I will talk to him about it. Just curious if anyone else is experiencing this, and if so, what are you doing to fix it?

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Jan 14, 2019 11:41AM IsabelArcher wrote:

TinyDancer, I had this off an on, both before cancer and after. Before cancer, it was caused by hormonal changes going into menopause. It felt like I had a bladder infection--urgency and burning, but when I would run to pee, not much came out--but there was no infection. At the time the midwife at my gyn prescribed estrogen cream to apply to the genital area. After using that briefly (maybe 2 weeks) the problem went away--it was a HUGE relief--and didn't return. Then after cancer, while on Tamoxifen, I sometimes had overactive bladder--having to pee a lot, and producing a lot. Post-Tamoxifen, I've been mostly back to normal. I never discussed with my onc whether the Tamox was to blame, I just assumed it. Curious to hear what yours will say. Good luck--I hope you're not too uncomfortable!

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jan 16, 2019 05:20PM Serenitysis wrote:

Hi Isabel, It sounds like you were on Tamoxifen for 5 years then stopped. Did your MO discuss staying on it longer? Mine said some people stay on for 10 years now, and “we’d talk about it when the time came.” I’ll have been on for 3 years in March.

PS: No bladder issues!

PPS: Regarding the previous thread, I have two friends who had some chemo first to reduce the tumor (early stage, but larger than most if not all of ours), the surgery, then more chemo - but weren’t on TDM1.



Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Jan 17, 2019 12:24PM IsabelArcher wrote:

Hi Serenity-- I was on Tamox for 4 years plus a few months. My onc took me off a little early because I was having slight gyn issues--not actual bleeding but a lot of discharge and some of it brownish. Ultrasound at gyn office showed a probable polyp. Possible (rare) SE of Tamox is uterine cancer so you can't mess around with this. After going off Tamox that gyn problem completely cleared up. I was supposed to have a followup U/S but I confess I have been too lazy. I will get around to it.

Anyway, when I started Tamox my onc and I had the exact same convo that you did with yours--that Tamox can be given for 10 yrs in some cases and we would revisit the issue later. What she concluded in my case, at the 4+ year mark, was that (a) the possible benefits of taking it were too small to outweigh the risk of the gyn issues I was having, and (b) for HER2 ladies the benefits are possibly negligible in any case. I think even without my gyn issues she was leaning toward stopping at 5 years.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jan 21, 2019 04:27PM TinyDancer5 wrote:

Isabel, thanks and I will discuss this with my dr.

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Jan 27, 2019 05:31PM Serenitysis wrote:

Hi Isabel, thank you for sharing your experience with Tamoxifen. I do have some issues with somewhat greater than normal discharge, but so far not too worrisome, just annoying. And I’m not sure whether to attribute it to the drug, anyway. I do intend to stop taking it after 5 years, unless I develop a reason to get off sooner.





Dx 5/2015, DCIS, Right, Stage 0, Grade 3, 0/1 nodes, ER+/PR- Dx 7/2015, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER+/PR-, HER2+ Targeted Therapy 11/9/2015 Kadcyla (T-DM1, ado-trastuzumab) Surgery Mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery Lumpectomy: Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (right): Silicone implant
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Feb 5, 2019 03:45PM - edited Feb 6, 2019 09:37AM by TinyDancer5

I met with my MO on Friday, and we discussed possibly staying on Tamoxifen for 10 years, but we'll discuss this again at my next visit. I am stopping the monthly Lupron injections and will have a blood test to check my estrogen levels next month. I am hoping they are lower and say that I am post-menopausal now. My latest bone density test results say that I have Osteopenia in my hips and lumbar spine which has increased since my last test 2 years ago. We discussed possibly taking Prolia or Reclast injections twice a year to protect my bones and keep them healthy. That's a decision I will make after I read more about the benefits and risks and side effects of both. Bladder issues - hmmm, maybe it is an UTI, but I have an appointment with my gyno on Friday for a check up.




Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Feb 7, 2019 10:37AM IsabelArcher wrote:

TinyDancer, did you have the bone density test 2 yrs ago for a particular reason? .

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Feb 7, 2019 03:00PM TinyDancer5 wrote:

Isabel, I was just curious to find out what condition my bones were in after I finished all of my treatments. When the results came back with osteopenia, I wanted to have another test to see if it has gotten worse.

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Feb 12, 2019 02:20PM IsabelArcher wrote:

Tiny--Thanks for explaining. Btw, this is a weird coincidence, but I've been dealing with that overactive bladder issue again--with symptoms that feel like a UTI but no infection. I'm going back on topical estrogen cream for a couple of weeks, prescribed by GYN and approved by my oncologist. Absorption is minimal so there is not thought to be any risk. I need relief!

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Feb 27, 2019 01:46PM TinyDancer5 wrote:

Dr said no UTI, just an over active bladder so she gave me a sample of Myrbetriq to try. I hope it works. After discussing my bone density test results, she did a "FORE 10 Year Fracture Risk Calculation" and it says Patient's Risks and Average Risk for Any of 4 Fractures in Next 10 Years - is 5%, and it shows that I am a low risk of fracture. So no need for Prolia or Reclast right now.

After reading about Osteopenia treatments I have decided to get my butt outside (as soon as it warms up - right now it's 24) and walk more, run around the block a few times, do weight bearing exercises and eat better (not that I wasn't eating good before). Then in two years I will have another bone density test and compare all of the results.

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Mar 1, 2019 11:19AM IsabelArcher wrote:

TinyDancer, sounds like a good plan!

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Apr 11, 2019 06:24PM MIPat wrote:

I have my annual mammogram tomorrow and I’ve kept it together pretty well. That is until my son refused to go to a taekwondo class and I ended up in the bathroom hyperventilating and crying. The positive point is that he didn’t know that this happened. I hate that I will have this feeling every year for the rest of my life

Surgery 5/30/2016 Lumpectomy: Right Dx 5/31/2016, IDC, Right, 1cm, Stage IA, Grade 2, ER-/PR-, HER2+ (IHC) Surgery 6/22/2016 Lumpectomy: Right; Lymph node removal: Sentinel Dx 6/23/2016, DCIS, Right, Stage 0, 0/1 nodes Targeted Therapy 7/31/2016 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 1/16/2017 Herceptin (trastuzumab)
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Apr 12, 2019 09:30AM IsabelArcher wrote:

MIPat, that fear is something we keep deep inside, locked up and very purposely ignored, until the annual day approaches. Then it takes over. I still haven't figured out if I'm better off squelching it as much as possible or letting it out. Brave face or crying mess--nothing in between! But you are SO NOT ALONE in this! Let us know how things went.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Apr 12, 2019 04:11PM MIPat wrote:

Thank you IsabelArcher. Test done and nothing abnormal found. Went into the bathroom for a stress reducing cry, texted my husband that our trip to Italy was still a go, and went for a brutal Chinese acupressure massage to get the tension and knots out of my body. Good for another year

I too am not sure if it is better to buck up or let it all come out as an ugly cry.

Surgery 5/30/2016 Lumpectomy: Right Dx 5/31/2016, IDC, Right, 1cm, Stage IA, Grade 2, ER-/PR-, HER2+ (IHC) Surgery 6/22/2016 Lumpectomy: Right; Lymph node removal: Sentinel Dx 6/23/2016, DCIS, Right, Stage 0, 0/1 nodes Targeted Therapy 7/31/2016 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 1/16/2017 Herceptin (trastuzumab)
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Apr 12, 2019 04:26PM MaggieCat wrote:

Great news MIPat! My personal trainer cancelled my session this morning. He was going with his wife for a follow-up breast imaging session. Hope she receives the same good news you did!


Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/31/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/16/2014 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 3/18/2015 Whole-breast
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Apr 15, 2019 10:04AM - edited Apr 15, 2019 10:04AM by IsabelArcher

MiPat--Woohoo! I'll tell you, though, I cannot walk into a mammo appt alone. I'm fortunate my husband can come with me (mammos in summer--he's off during summer months). If he couldn't go, I'd have to enlist a friend. I can't do it alone. But try to forget about this completely for another 364 days.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Apr 15, 2019 07:22PM TinyDancer5 wrote:

Congratulations MIPAT!

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Apr 20, 2019 11:48AM MIPat wrote:

Thanks everyone. IsabelArcher my husband offered to come with me, but I told him that he didn’t need to. He couldn’t be with me for a large part of the waiting time. I sometimes have a harder time holding together when I have someone trying to be sympathetic or empathetic. Goes back to when I was 13 and my father died. Luckily I have enough going on with my kids (good and bad) that I am easily distracted the other 364 days. Hope everyone gets good news this y

Surgery 5/30/2016 Lumpectomy: Right Dx 5/31/2016, IDC, Right, 1cm, Stage IA, Grade 2, ER-/PR-, HER2+ (IHC) Surgery 6/22/2016 Lumpectomy: Right; Lymph node removal: Sentinel Dx 6/23/2016, DCIS, Right, Stage 0, 0/1 nodes Targeted Therapy 7/31/2016 Kadcyla (T-DM1, ado-trastuzumab) Targeted Therapy 1/16/2017 Herceptin (trastuzumab)
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Apr 22, 2019 10:20AM IsabelArcher wrote:

MIPat, I totally understand. Similar emotional issues since my father died when I was 16. Happy spring to you and to all.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)

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