Topic: Kadcyla for residual disease after neo adjuvant chemo

Forum: HER2+ (Positive) Breast Cancer — Testing, treatment, side effects, and more.

Posted on: Oct 30, 2019 10:20AM

Posted on: Oct 30, 2019 10:20AM

neeli wrote:

Hi All,

Starting a new Kadcyla thread as there wasn't one before. I will be starting Kadcyla soon as there was residual disease from surgery pathology report. Kadcyla for 14 cycles is what is recommended. Any of you who have already been on Kadcyla please share how it is going for you.

Dx 4/24/2019, DCIS/IDC, Right, Grade 3, 3/10 nodes, ER+/PR+, HER2+, Chemotherapy 6/4/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 6/4/2019 Perjeta (pertuzumab) Targeted Therapy 6/5/2019 Herceptin (trastuzumab) Surgery 10/16/2019 Mastectomy: Right Targeted Therapy 11/6/2019 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 12/4/2019 Whole breast: Breast, Chest wall
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Feb 23, 2022 03:42PM morrigan_2575 wrote:

I didn't lose hair on Kadcyla. My hair growth might have slowed down but, it still grew and didn't thin or fall out.


Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IIA, Grade 2, ER+/PR+, HER2+, Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Surgery 6/18/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 6/19/2020, DCIS/IDC, Right, <1cm, Stage IA, Grade 2, 1/3 nodes, ER+/PR+, HER2+ Targeted Therapy 7/5/2020 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 8/9/2020 Whole breast: Breast, Lymph nodes, Chest wall
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Feb 23, 2022 04:48PM sarah_78 wrote:

Thank you Yeslama and morrigan, hope it will be the same for me.

DIagnosed at 43, Hodgkin's Survivor (at 33) Chemotherapy 9/24/2021 Other Targeted Therapy 2/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Dx IDC/DCIS, Left, 5cm, Stage IIIA, Grade 3, 2/11 nodes, ER-/PR-, HER2+, IHC
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Feb 24, 2022 01:09AM alwaysmec wrote:

Sarah, I get lots of compliments on how thick my hair is. It looks like I got a pixie cut on purpose. It was buzz cut the first week of October after I used a cold cap, so it could grow back evenly. Even though it's super thick, I feel like my hair and nails are growing slower than they did before chemo and Kadcyla.

Chemotherapy 4/29/2021 Other Targeted Therapy 4/29/2021 Kanjinti Targeted Therapy 4/29/2021 Perjeta (pertuzumab) Targeted Therapy 9/2/2021 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.phesgo Targeted Therapy 9/20/2021 Herceptin (hylecta) Surgery 9/23/2021 Lumpectomy (Left); Lymph node removal (Left): Sentinel Chemotherapy 11/12/2021 Other Targeted Therapy 5/3/2022 translation missing: en.treatments.targeted_therapy.targeted_therapy_medicine.short_options.phesgo Dx IDC/DCIS, Left, 1cm, Stage IIA, Grade 2, 1/4 nodes, ER-/PR-, HER2+, ISH, IHC
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May 20, 2022 03:51PM sarah_78 wrote:

Hi Kadcyla ladies,

I am on 5th cycle, 14 planned. I am doing well but liver values are slowly creeping up.

Anyone had this problem? Doctor didn't seem concerned with them just yet but seeing them go up each three weeks worry me. Values: GOT/ASAT is now 61 U/l (normally should be below 35) and GPT/ALAT is 62 (also should be below 35). They were normal when we started and each time went up just a bit more. Doctor says they will check with ultrasound if it goes above 100 and this happens often. Anyone in the same boat to give me a peace of mind?

DIagnosed at 43, Hodgkin's Survivor (at 33) Chemotherapy 9/24/2021 Other Targeted Therapy 2/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Dx IDC/DCIS, Left, 5cm, Stage IIIA, Grade 3, 2/11 nodes, ER-/PR-, HER2+, IHC
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May 21, 2022 08:26PM noodlesg wrote:

Hi everyone,

My first post in this thread. I just started Kadcyla mid-April, I've done 2 out of 14 so far. It's been okay, much better than chemo. I'm a bit nauseous on days 4-5. Have a bit of fatigue, but also doing radiation concurrently, so am sure that doesn't help.

Sarah - my ASAT is 42 U/l ALAT is 48 U/l after the first infusion, will let you know if the numbers get worse when they do the next blood test. They were normal before treatment started. I did ask my onco about this, and she compared it to a mild inflammation, and will go away after treatment ends. My doctor gives me Heptral (ademetionine) to support my liver.

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May 22, 2022 01:52PM sarah_78 wrote:

noodlesg, glad to hear you are doing good after your treatments.

After the second one mine was also about 40ish, then one more went up to 55 and right now 61. Please keep me updated. I'll ask my doctor about Heptral.

DIagnosed at 43, Hodgkin's Survivor (at 33) Chemotherapy 9/24/2021 Other Targeted Therapy 2/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Dx IDC/DCIS, Left, 5cm, Stage IIIA, Grade 3, 2/11 nodes, ER-/PR-, HER2+, IHC
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Jun 2, 2022 08:16PM - edited Jun 3, 2022 08:49PM by noodlesg

Sarah, I just had my 3rd infusion yday. My pre-infusion liver nos went down, both 38. So this is refective of infusion #2. I was expecting everything to be worse because I had radiation the past 3 wks, but am happily surprised. With breast cancer, I've learned to appreciate all the happy surprises I get! Never know what's around the corner.


Hope your numbers are okay! When do you go in for the next infusion

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Jun 3, 2022 04:10PM sarah_78 wrote:

noodle, I am glad to hear that. My 6th cycle is next week and hoping for better values or hopefully not a drastic change from last time.

Last week I had an appointment to check with my oncologist and he said the current liver enzyme values (ASAT/ALAT) at 61 is no problem at all, it is expected and should go down once the therapy is done. That is assuring but I am reading in Kadcyla web page that one has to cut the medication at 100, I will speak to the doctor about it again.

What I did this time around is that I stopped taking Vitamin D thinking it might be another exhaustion for the liver but now I am reading actually vit D helps liver. Confused.

DIagnosed at 43, Hodgkin's Survivor (at 33) Chemotherapy 9/24/2021 Other Targeted Therapy 2/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Dx IDC/DCIS, Left, 5cm, Stage IIIA, Grade 3, 2/11 nodes, ER-/PR-, HER2+, IHC
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Jun 16, 2022 09:34AM sarah_78 wrote:

I am reporting, 6th cycle done, ASAT/ALAT stayed the same, went a little down, 57-60 right now.

I am not taking D vitamin anymore, doctor on site couldn't answer my the question I had about having D Vitamin helping liver or not, my value is just at the lowest border for Vitamin D, sun is shining, so I think it won't drop for a few months.

How are your values noodlesg?

On me they also measure bilirubin, that one isn't out of range for now.

DIagnosed at 43, Hodgkin's Survivor (at 33) Chemotherapy 9/24/2021 Other Targeted Therapy 2/1/2022 Kadcyla (T-DM1, ado-trastuzumab) Dx IDC/DCIS, Left, 5cm, Stage IIIA, Grade 3, 2/11 nodes, ER-/PR-, HER2+, IHC
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Jun 29, 2022 01:00AM - edited Jun 29, 2022 02:04AM by noodlesg

Hi Sarah, sorry I hadn't replied earlier. I just returned from holiday, my first one in 2.5 yrs. With all this craziness of covid, then this diagnosis, it was much needed. Stark reality of coming back though, was my infusion earlier today. Sigh. My readings were a little worse than last time, AST 51, ALT 58. So I think I must be exactly where you were? Today was my 4th, so I'm prepared for it to be in the 60's in 3 wks time. My onco wasn't bothered about the number, but the nurse slipped and said ' Your bloodwork is totally fine except for liver, it's gone a bit haywire.' Really? hahhaha I actually went back to check my liver numbers when I did chemo, ALT went up as high as 165, but it came down.

I take calcium supplements (Caltrate), and it has vitamin D as well, so I'm not taking any extra. Not sure it's helping my liver either, but it helps to facilitate calcium absorption, so if there's an added bonus, I'd be happy. But my liver numbers aren't stellar, so maybe it's not doing much.

My bilirubin is 0.52 mg/dL, in the normal range.

Just curious, how is yr hair growing after 6 infusions? I haven't lost any(not noticeable at least), but I'm not sure it's growing as fast as it normally would. Maybe it's my imagination? It was growing out so fast a few wks after my last chemo, even my 8 yr old commented. I'm still waiting with eager anticipation for it to grow more.

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