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Topic: Kadcyla for residual disease after neo adjuvant chemo

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Oct 30, 2019 12:20PM

neeli wrote:

Hi All,

Starting a new Kadcyla thread as there wasn't one before. I will be starting Kadcyla soon as there was residual disease from surgery pathology report. Kadcyla for 14 cycles is what is recommended. Any of you who have already been on Kadcyla please share how it is going for you.

Dx 4/24/2019, DCIS/IDC, Right, Grade 3, 3/10 nodes, ER+/PR+, HER2+ (IHC) Targeted Therapy 6/5/2019 Perjeta (pertuzumab) Targeted Therapy 6/5/2019 Herceptin (trastuzumab) Chemotherapy 6/5/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 10/17/2019 Mastectomy: Right Targeted Therapy 11/7/2019 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 12/5/2019 Whole-breast: Breast, Chest wall
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Jun 29, 2020 05:03PM morrigan_2575 wrote:

are there any support drugs given with Kadcyla? Steroids? Benadryl? Etc

Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IIA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Surgery 6/18/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 6/19/2020, DCIS/IDC, Right, <1cm, Stage IA, Grade 2, 1/3 nodes, ER+/PR+, HER2+ Targeted Therapy 7/5/2020 Kadcyla (T-DM1, ado-trastuzumab)
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Jun 29, 2020 05:57PM cyathea wrote:

morrigan_2575, I did not take any support drugs with Kadcyla. I have the option to take Zofran for nausea but I have not needed that

Dx 6/17/2019, DCIS/ILC, Right, 5cm, Stage IV, metastasized to bone, Grade 2, ER+/PR-, HER2+ (FISH) Targeted Therapy 8/1/2019 Perjeta (pertuzumab) Chemotherapy 8/1/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Chemotherapy 10/9/2019 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 10/10/2019 Herceptin (trastuzumab) Surgery 3/18/2020 Lymph node removal: Left, Right, Sentinel, Underarm/Axillary; Mastectomy: Left, Right Chemotherapy 4/16/2020 Other Radiation Therapy 6/1/2020 3DCRT: Breast, Lymph nodes, Bone Targeted Therapy Herceptin (trastuzumab)
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Jun 29, 2020 06:01PM morrigan_2575 wrote:

Thanks!

Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IIA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Surgery 6/18/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 6/19/2020, DCIS/IDC, Right, <1cm, Stage IA, Grade 2, 1/3 nodes, ER+/PR+, HER2+ Targeted Therapy 7/5/2020 Kadcyla (T-DM1, ado-trastuzumab)
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Jun 29, 2020 06:29PM YesIamaDragon wrote:

Morrigan -- I have been offered anti-nausea meds and antacid IV but have declined, so I just get the infusion. Makes for a much shorter infusion day than TCHP for sure!

I saw your post in the other thread about thigh pain! I felt like I had run up Mt. Washington pretty much every day by the end. But without the strength and endurance gains :) In fact, it has taken me months to get back the strength I lost in that area (even to do basic things I never thought about before like get off the floor without pushing with my hands).

The Kadcyla seems to be kicking my butt in different ways, but most people tolerate it very well.

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Jun 29, 2020 08:15PM AngieB92 wrote:

I’m offered Benadryl (which I refuse) and Tylenol (which I take in case of joint/muscle pain). I still hydrate like crazy before, during, and after the infusion

Dx 8/8/2019, IDC, Left, 1cm, Stage IA, Grade 2, 0/6 nodes, ER+/PR+, HER2+ (IHC) Targeted Therapy 9/17/2019 Perjeta (pertuzumab) Targeted Therapy 9/17/2019 Herceptin (trastuzumab) Surgery 3/3/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Targeted Therapy 4/10/2020 Kadcyla (T-DM1, ado-trastuzumab)
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Jun 30, 2020 12:09PM morrigan_2575 wrote:

Its official I'm switching over to Kadcyla for 14 Cycles next week. They canceled my HP treatment for tomorrow and, booked me and appointment with my MO on Monday. I'll either get my first Kadcyla treatment on Monday or shortly after depending on my blood counts.

Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IIA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Surgery 6/18/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 6/19/2020, DCIS/IDC, Right, <1cm, Stage IA, Grade 2, 1/3 nodes, ER+/PR+, HER2+ Targeted Therapy 7/5/2020 Kadcyla (T-DM1, ado-trastuzumab)
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Jun 30, 2020 07:56PM YesIamaDragon wrote:

Morrigan -- a few pages pack folks recommended Biotene mouthwash and xylitol melts for the dry mouth, and they have been lifesavers! The melts are especially helpful for mask-wearing situations.

In other news, after 3 of the worst days of my life, it seems the worst of my symptoms have been from the aromatase inhibitor, and now after 3 days off the AI my symptoms are MUCH better. So the Kadcyla is off the hook. On the other hand, the hormone blocker is also critical to my prognosis :( Today the Oncologist asked if I had fibromyalgia as they have noticed people with fibromyalgia tend to have a lot more pain with the aromatase inhibitors. So we shall see. Perhaps I will have to wait on the hormonal treatment until I am done with Kadcyla.

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Jun 30, 2020 08:24PM - edited Jun 30, 2020 08:30PM by morrigan_2575

@yeslama - I was reading a BC Support Group on Facebook and this topic came up. People there said there are a bunch of AIs available and it's a matter of finding the right AI for you. If this one isn't working ask your MO to prescribe a new one.

I use Biotine, Mouthwash, toothpaste and spray as well as the Xylitol. I went to the Dentist on Monday and asked them, they said that's pretty much all you can do.

They did give me the Prevident Dry Mouth toothpaste. They said it would be better since it has Fluoride which would protect against cavities.

Dx 1/20/2020, DCIS/IDC, Right, 4cm, Stage IIA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 2/4/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 2/4/2020 Herceptin (trastuzumab) Targeted Therapy 2/4/2020 Perjeta (pertuzumab) Surgery 6/18/2020 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Dx 6/19/2020, DCIS/IDC, Right, <1cm, Stage IA, Grade 2, 1/3 nodes, ER+/PR+, HER2+ Targeted Therapy 7/5/2020 Kadcyla (T-DM1, ado-trastuzumab)
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Jul 1, 2020 10:04PM Flowerkid wrote:

Yesmla so glad you are doing at least a bit better. Sounds like quite a rough spell there. It must be such relief to actually identify the causes.

I take a steroid right before infusion and that's it. 8th kadcyla infusion yesterday! One week of tamoxifen.

Tonight I am having my first drink of golden milk, recommended by an integrative oncologist who I finally got an appointment with. It is supposed to boost immune system, reduce inflammation and so many other benefits . Will see. It does taste good!


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16 hours ago Flnana2 wrote:

Hi,

I'm looking to see if anyone else has had this issue. Last week I was diagnosed with radiation pneumonitis and started on 15 days of prednisone and a strong antibiotic. Today, I went for my 9th Kadcyla infusion and my MO cancelled my infusion today and pushed my next infusion back three weeks because of the pneumonitis. The last time I had an infusion was June 9th and now I won't have another til July 30th...52 days!!! I'm concerned that there is such a long time between treatments.....Has anyone else had this same situation and if so, how did your Dr. handle it?


Thanks for your help!

Julie

Dx 6/19/2019, ILC, Left, 3cm, Stage IIB, Grade 2, ER+/PR+, HER2+ (FISH) Chemotherapy 7/23/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 12/9/2019 Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab)
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13 hours ago cyathea wrote:

Flnana2, I don’t think you need to worry too much. It’s common to have gaps in chemo. I was off chemo for about 6 weeks last year due to liver and gallbladder issues.

I also requested to be taken off Kadcyla for the last few treatments and to take just Herceptin instead due to radiation SEs. My MO said this was fine in my case.You could ask your MO about this option for your case.

Dx 6/17/2019, DCIS/ILC, Right, 5cm, Stage IV, metastasized to bone, Grade 2, ER+/PR-, HER2+ (FISH) Targeted Therapy 8/1/2019 Perjeta (pertuzumab) Chemotherapy 8/1/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Chemotherapy 10/9/2019 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 10/10/2019 Herceptin (trastuzumab) Surgery 3/18/2020 Lymph node removal: Left, Right, Sentinel, Underarm/Axillary; Mastectomy: Left, Right Chemotherapy 4/16/2020 Other Radiation Therapy 6/1/2020 3DCRT: Breast, Lymph nodes, Bone Targeted Therapy Herceptin (trastuzumab)

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