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Topic: New BCO Content on Recently Approved Phesgo

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Jul 9, 2020 11:12AM

Moderators wrote:

Check out our new content on Phesgo (chemical name: pertuzumab, trastuzumab, and hyaluronidase-zzxf), a fixed-dose combination of Herceptin (chemical name: trastuzumab), Perjeta (chemical name: pertuzumab), and hyaluronidase-zzxf used to treat all stages of HER2-positive breast cancer in combination with chemotherapy.

Read all about Phesgo here.

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Dec 3, 2020 11:34AM - edited Dec 3, 2020 11:37AM by dlr68

I just wanted to say that I'm 52 years old, diagnosed 9 months ago stage 2a T2 N0(i+) M0 with LVI found during right mastectomy (I was surgery first, then 6 cycles of TCHP and now on #11 of HP). I never had a port placed because I thought I was going to get Herceptin Hylecta after TCHP. I am wondering what are side effects of mono therapy of Phesgo..in other words when someone is on just HP or just on Phesgo? I received my first dose of Phesgo 1 1/2 weeks ago. It was my nurse's first time giving it. I am thin and not much sub Q fat. The nurse was able to get most of the medicine in my thigh, but some of it was backing up out of my skin around the needle towards the end of my injection. She was injecting it appropriately. I also started having more soft stool issues as well as more nausea and headaches after Phesgo. I was having completely normal stools after TCHP up until my last HP and this dose of Phesgo. I also had new generalized mild muscle weakness after Phesgo. My MO said that all my side effects lately should not be related to the HP or Phesgo. The Phesgo is the same as HP with exception of the Hyaluronidase that is in the Phesgo. The Hyaluronidase should not go systemic. I also tolerated the Herceptin Hylectin that also has the Hyaluronidase. Anybody had anything similar to this? Thanks



Dx 3/2020, DCIS/IDC, Right, 2cm, Stage IIA, Grade 3, 1/6 nodes, ER+/PR+, HER2+ (FISH) Surgery 3/26/2020 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel)
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Dec 3, 2020 12:07PM Moderators wrote:

Hi dlr68, and welcome to Breastcancer.org,

We're sorry for the reasons that bring you here, but really glad you've found us. You're sure to find our Community a helpful source of information, advice, encouragement, and support -- we're all here for you!

Others will likely be by soon to weigh in with their experiences with Phesgo. In the meantime, we wanted to point you to the main Breastcancer.org site's Phesgo page, particularly the section on Side Effects as some of the effects you've experienced are listed as common.

We hope this helps and you get some answers and shared experience from others here soon! Please let us know if you need anything at all as you navigate our boards!

--The Mods

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