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Topic: Herceptin and Cardiac Issues

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Aug 6, 2020 08:36PM

Bejeweled wrote:


I’ve been on Herceptin (with Taxol and then alone) for about 6 months. Oncologist called today and said my ejection fraction and strain pattern are no longer in normal range and we have to stop Herceptin.

Has anyone else been through this? Is there an alternative to Herceptin? I’m concerned that my chance of recurrence will be higher since I didn’t do the year of Herceptin.

She referred me to go see a cardiologist, which I will do, but am nervous that now I have some kind of big cardiac issue on top of everything else.

Any advice appreciated

Dx 8/27/2019, IDC, Left, 4cm, Stage IIA, Grade 3, 1/3 nodes, ER+/PR-, HER2+ (FISH) Surgery 10/28/2019 Lumpectomy: Left; Reconstruction (left); Reconstruction (right) Chemotherapy 12/4/2019 AC + T (Taxol) Targeted Therapy 1/29/2020 Herceptin (trastuzumab) Radiation Therapy 5/13/2020 Whole-breast: Breast, Lymph nodes Hormonal Therapy 7/1/2020 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy
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Aug 7, 2020 02:21AM fishingal68 wrote:


I had to stop neoadjuvant Herceptin after the fifth round due to cardiac issues as well. I then had my surgery, radiation, and started Herceptin back up after all of those treatments. Again, it caused cardiac issues, so I never finished that year-long course either.

My cardiologist said the heart issues may get better or it may not, so I am on 2 different meds to keep my heart working properly.

You are not alone. Hang in there!

Dx 9/7/2017, DCIS/IDC/IDC: Cribriform, Right, 2cm, Stage IIB, Grade 3, 1/3 nodes, ER-/PR-, HER2+ Targeted Therapy 10/10/2017 Herceptin (trastuzumab) Chemotherapy 10/10/2017 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 2/16/2018 Mastectomy; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 5/14/2018 Whole-breast: Breast, Lymph nodes, Chest wall
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Aug 7, 2020 05:33PM MinusTwo wrote:

Usually heart problems caused by Herceptin are reversible and clear up. Unlike heart problems caused by Adriamycin. The cardiologist should be able to clarify. Good luck

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014

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