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Topic: About to start care- just got initial ER/PR and HER2+

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Sep 15, 2020 02:36PM

AbbyRhodes3 wrote:

I'm both trying to research and also not get ahead of myself - which really isn't possible. But I received my pathology report today, and it indicates low positive values on the ER and PR, and +3 on HER2. Specifically:

Estrogen Receptor Protein - Low Positive - 5%
Progresterone REceptor Protein- Low Positive - 1%
Her-2 NEC encoprotein is Positive (3 + 100%)

I was a little panicked that the nurse said they might opt for chemo first- but after some reading here, I think I see indications why. No other data yet- grading or such. It's IDC, and 1.3 cm.

Are there others in the same category - low on both hormone receptors, and HER2+? The report also has the fairly standard sentence that: "Data suggests IC with those results are heterogenous in behavior and biology and often have gene expression prifiles more similar to ER negative cancers."


Dx 9/8/2020, IDC in right breast, 1cm | ER+ 5% | PR+ 1% | HR2+ x3
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Sep 15, 2020 03:47PM MinusTwo wrote:

HER2+ almost always means chemo first. It's aggressive so they like to give it a hard shot before surgery. You should have imaging before Chemo & again after so they will be able to tell how much the tumor shrank or disappeared.

I was ER/PR negative. Hopefully someone else will come along who knows more, but I guess it's possible they could choose chemo based on negative or positive receptors since your numbers are so low.

2/15/11 BMX-DCIS 2SNB clear-TEs; 9/15/11-410gummies; 3/20/13 recurrance-5.5cm,mets to lymphs, Stage IIIB IDC ER/PRneg,HER2+; TCH/Perjeta/Neulasta x6; ALND 9/24/13 1/18 nodes 4.5cm; AC chemo 10/30/13 x3; herceptin again; Rads Feb2014
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Sep 21, 2020 06:14PM AbbyRhodes3 wrote:

@minustwo - thank you for this info. Going for first consult tomorrow, will learn more.

Dx 9/8/2020, IDC in right breast, 1cm | ER+ 5% | PR+ 1% | HR2+ x3

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