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Mar 19, 2013 07:16AM
Mar 19, 2013 07:18AM
Like you I've been voraciously consuming literature on Luminal B for weeks now, hoping to find some kind of answer in there. My understanding is that the proliferation rate (Ki67) is what really distinguishes B (Ki67>13.25%) from A (Ki67<13.25%) so it sounds to me like a cell behavior. One can be Luminal B and PR+ too - being PR- does not figure into the determination of Luminal A or B, but being PR- does increase recurrence rates even within the Luminal B category:
My original pathology report does not include Ki67, and treatment was based solely on the cancer profile. It is only when the Oncotype test was done (which includes Ki67) that the cancer profile suddenly changed - as did my stats. So I personally don't necessarily have a lot of faith in *just* the pathology report if it does not include more information (like Ki67, perhaps p53, and other tests too).
And yes, you're right, it's still not as bad for recurrence as basal (TN). Stupid cancer.
I suspect that my MO's concern about "higher than 18%" alludes to being PR- (see report above), but I don't know. I could be totally wrong. The more I try to figure this out, the less I actually know. :-)
All I *do* know is that this practice had never seen such a high Oncotype score before (which really surprised - and scared - me). I sometimes feel like a guinea pig to be researced. :-) So I put my faith in the treatment I've received, and try to make life changes to help along the way, and try not to freak out every time I get a twinge in my back or hip, and...and...and...and keep my fingers crossed a little, too.
Edited to clean up my pre-coffee typos...
"Be happy for this moment. This moment is your life." - Omar Khayyam
12/5/2011 Lumpectomy; Lumpectomy (Left); Lymph node removal
1/19/2012 AC + T (Taxol)
6/12/2012 Whole breast: Breast, Lymph nodes
2/15/2016 Lumpectomy; Lymph node removal; Lymph node removal (Left)
3/1/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
7/21/2016 Mastectomy; Mastectomy (Left); Reconstruction (Left): DIEP flap