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All TopicsForum: High Risk of Recurrence or Second Breast Cancer → Topic: Dfsp skin cancer and Her2+

Topic: Dfsp skin cancer and Her2+

Forum: High Risk of Recurrence or Second Breast Cancer — Managing high recurrence risk of developing a second breast cancer.

Posted on: Jun 30, 2017 01:49PM

Ljstolp wrote:

Has anyone had any experience with this?? I saw an old post but now I cant find it..

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Jun 30, 2017 04:40PM - edited Jun 30, 2017 04:43PM by SpecialK

I used the search function and put in both dfsp and the longer dermatofibrosarcoma protuberans, and only got one mention and it was part of a description someone posted. I had Her2+ breast cancer at 54, but was diagnosed with the first skin cancer (BCC) at 35. Since then I have had at least 30 confirmed basal cell malignancies and an accelerated number since breast cancer diagnosis that have needed to be removed by wide excision, or have recurred and then required MOHS surgery. I was just diagnosed with my first infiltrating one last month, and this is a more aggressive form of basal cell. I has me wondering if there is any link. I know that DFSP is a sarcoma, but I also had a 3cm nerve sheath tumor in my calf muscle that was originally thought to be a sarcoma, and a 3cm pre-malignant ovarian mass found inadvertently after a total hyst/ooph for uterine fibroids, too numerous to count.

BMX w/ TE 11/1/10, ALND 12/6/10. 14 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC) Dx 9/27/2010, DCIS, Stage 0, Grade 3
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Jun 30, 2017 06:05PM Ljstolp wrote:

i researched a little and found out that mutations for both types of cancer are on chromosome 17. It worries me bc my cousin who has an extensive history with skin cancers was jist diagnosed with dfsp. Me being her2+ im just curious if there is a correlation. Has your onco said anything about it??? Are they related

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Jun 30, 2017 08:33PM SpecialK wrote:

My MO is aware, but does not seem overly concerned. After this most recent diagnosis of infiltrating BCC I did go to see him for two reasons - initially this BCC was diagnosed as a superficial, which most of mine have been. It was treated and recurred very quickly - less than 6 months, now diagnosed as infiltrating. This is one of the only types of basal cell skin cancers that can become metastatic and require chemo and rads. It is geographically very close to my breast cancer and previous positive nodes, and I was concerned because this type grows inward rather than spreading on the surface of the skin. The removal is not for another 3 weeks so I was a bit worried, and wanted his input on that - my MO called my derm (they went to med school together) but no traction on moving up the surgery, so - I will wait and quiz the derm on whether this was initially misdiagnosed, or if it changed when it recurred and question why it became more aggressive if that is the case. I have had one cancer related doc (microvascular PS treating my lymphedema) ask if I have been diagnosed with Basal Cell Syndrome, but I don't have any of the other signs that I am aware of.

BMX w/ TE 11/1/10, ALND 12/6/10. 14 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC) Dx 9/27/2010, DCIS, Stage 0, Grade 3

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