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Topic: Long term luminal b survivors!?

Forum: High Risk of Recurrence or Second Breast Cancer — Managing high recurrence risk of developing a second breast cancer.

Posted on: Dec 12, 2019 06:00PM

Swko wrote:

hi just found out I am luminal b. I am her 2 negative er 99% pr 30%. My mammaprint stated I am high risk at 29% chance of recurrence but endocrine therapy and chemo would bring it down to 5 percent so I guess that's decent Anyone else with a similar situation? Any words of encouragement would be great!

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Feb 26, 2020 01:40PM Natural wrote:

Did your MO review the Mammaprint with you? I was shocked when I got my results a few days ago for high risk luminal B. The first page of the report is very misleading. I am fortunate to have found a contact with an Agendia print who provided explanation. Are you clinically low risk??

Dx 9/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery
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Feb 26, 2020 03:51PM HeartShapedBox wrote:

it's important to remember that luminal b is THE most common subgroup @ 40%, and that it's only one piece of your puzzle of factors that can put you at higher or lower risk of recurrence. Yes as a factor in and of itself weighed against non-luminal patients it's associated with poorer long term prognosis in terms of local recurrence and metastasis, but there are MANY other factors (type of breast cancer, size and grade of tumor, HER2 and hormone status, nodal involvement, not to mention treatments) that make up the whole picture of risk.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53231...


Diagnosed at age 43. Triple + luminal B regional spread to lymph nodes, pathological TNM stage llB after 6 sessions neoadjuvant TCHP (dropped perjeta after 4 doses), initial clinical stage lllA Dx 5/24/2019, IDC, Left, 5cm, Stage IIIA, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 8/1/2019 Perjeta (pertuzumab) Targeted Therapy 8/1/2019 Herceptin (trastuzumab) Chemotherapy 8/1/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Dx 12/27/2019, DCIS/IDC, Left, 4cm, Stage IIB, Grade 2, 2/8 nodes, ER+/PR+, HER2+ (IHC) Surgery 12/27/2019 Lymph node removal: Underarm/Axillary; Mastectomy: Left Radiation Therapy 3/4/2020 Whole-breast: Lymph nodes, Chest wall
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Feb 27, 2020 09:33AM - edited Feb 27, 2020 09:50AM by Natural

But what if clinical / path report doesn't fit luminal B? I am hormone positive with estrogen at 99% and progesterone 80+ % (I'd have to look up), her2 neg per FISH. Ki67 is 8%. My path report is grade 1. Tubular is 3 and the other two factors are 1 including mitosis. I really don't understand when all clinical factors that I am aware for luminal B do not fit. The mammaprint was from the surgical bx. I had core needle vacuum bx for initial bx. Small tumor measured 6 mm on the original US's. MRI after that did not show any tumors. Experienced radiologist said the marker was the only way she found the bx site. Two US's preparing for sentinel node did not show any growth. BS said there was cancer in the surgical bx but where did 9 mm come from? All margins negative,tissue removed from bilateral reduction negative, and 2 sentinel lymph nodes negative. Wondering if mammaprint accurate? Of course we all want to see what we expect / hope. My BS says has never seen stage 1 with high mammaprint. Lots of questions for upcoming appt with MO. I appreciate the article and will read closely. I, like many of us, am becoming a wealth of knowledge re breast cancer. Thank you






Dx 9/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery
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Feb 27, 2020 02:59PM Cricketdog wrote:

Swko - my results were very similar to yours - luminal B and E+ and P+ with high risk Mammaprint score of 29%. Did you start any treatment? I started TC 2 weeks ago.

Natural - I was stage 1 as well (1.8 cm mass) and Mammaprint high risk. My MO was not overly surprised with my results. He worked for Agendia years ago. He stopped testing already high risk patients with Mammaprint some time ago because the scores come back so high that it's really disheartening for patients.

Dx 10/2019, ILC/IDC, Left, 1cm, Stage IB, Grade 2, 0/3 nodes, ER+/PR+, HER2- Radiation Therapy 1/12/2020 3DCRT: Breast, Lymph nodes Chemotherapy 2/13/2020 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery Lumpectomy: Left; Lymph node removal: Sentinel
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Feb 27, 2020 03:40PM Natural wrote:

I am first seeing the MO in a couple of weeks as visiting family. My only plan was low dose tamoxifen. After connecting with an agendia rep, i found out the front page of the report is an aggregate for all high risks. Since i am low risk clinically, the advantage of chemo is 2.5%. With toxicity of chemo of abt 2%, no to chemo. I am also 65 with grown children and a loving husband who accepts my decision making. There is a study regarding discordant reports. 9% are low clinical, high Mammaprint. The rep sent info. Kept me from freaking out since my BS had never seen a stage 1, grade 1 as high risk and didn’t know how to interpret. I am still not confident about the mammoprint results.

Dx 9/2019, IDC, Right, <1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- (FISH) Surgery

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