Jan 11, 2011 05:23AM - edited Jan 11, 2011 05:40AM by leaf
There is controversy about this. Some pathology reports don't give any information beyond 'LCIS'; others detail the type of LCIS (such as type A, B, classic, pleomorphic, etc.) This may or may not be important. (Most feel that pleomorphic has the potential for more aggressiveness than classical. Most LCIS is classic which includes type A and B.)
Type A pattern: small, round, bland cells; diploid
Type B pattern: larger cells with more cytoplasm, less uniform nuclei and distinct nucleoli http://www.pathologyoutlines.com/topic/breastmalignantlcis.html
Here's another paper about types of LCIS (even more technical) http://labmed.ucsf.edu/uploads/207/100_lobular_breast_cancer_current_issues_%202010.pdf.
As I mentioned before, the type of classic LCIS may or may not matter. (Although I think most believe pleomorphic may be more aggressive.)
Also, different pathologists/pathology labs may have different criteria for different classifications, and one pathologist may describe the cells differently than another pathologist, even if they use the same criteria.
This paper recommended excision for NG (nuclear grade) 2+3 . (Pleomorphic is nuclear grade 3.) www.ncbi.nlm.nih.gov/pubmed/20...
Against (at least in certain cases):
www.ncbi.nlm.nih.gov/pubmed/18... (no abstract)
www.ncbi.nlm.nih.gov/pubmed/18... by the American Cancer Society) Excision of LN is unnecessary provided that: 1) careful radiographic-pathologic correlation is performed; and 2) strict histologic criteria are adhered to when making the diagnosis. Close radiologic and clinical follow-up is adequate.
Controversy means you can't choose wrong! This is your body and your choice. Make the choice that is best for YOU after you have looked at your heart (how you feel about the choices) and your head (the risks and benefits.)