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Topic: Chemoprevention or not

Forum: LCIS (Lobular Carcinoma In Situ) — Just diagnosed, in treatment, or finished treatment for LCIS.

Posted on: Nov 24, 2017 08:13AM

NicolaSue wrote:

HI All,

I've got myself in a real muddle and I'm wondering if anyone can help me.

I had LCIS diagnosed in February. I was told I may be menopausal and if so that's good as we might be able to get away without any chemoprevention if my oestrogen is low. So I've had three oestrogen tests now and they've all come back as <44 (oestradiol). This lab doesn't measure below this level so essentially I have oestrogen levels too low to be detected.

But....is that the whole story?

Are there other forms of oestrogen apart from oestradiol that my body might be making? And/or just because I am <44 doesn't mean I guess that I'm going to stay <44. Presumably the level could suddenly creep up.

Also, might it be important to find a lab that can measure below 44? I mean I could be at 43 and this particular lab would still have reported it as undetectable as it's below the key 44 level.

I've got myself really stressed over this.

I'm trying to avoid chemoprevention as I've had a total thyroidectocy and it's the devil's own job to get on top of the drug thyroxine. I would be very scared about adding anything in to the mix.


LCIS diagnosed Spring 2017. Vacuum excision biopsy. First follow up mammo 2018 - clear
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Nov 24, 2017 10:38AM - edited Nov 24, 2017 11:01AM by Hi-Risk-4BC

I have Classic LCIS, premenopausal, with history of asymptomatic, idiopathic blood clots in one eye, so Tamoxifen is not a good option for me. My efforts will concentrate on controlling what I can, my nutrition and exercise. I am still trying to learn about all of this. This has been a helpful source of info for me: nutrition facts breast-cancer-prevention-which-mushroom-is-best . Good luck to you!

P.S. Getting a second opinion should never make a good doctor feel threatened. It's your life and your right.

Sept 2017: core needle biopsy results flat epithelial atypia & Atypical lobular Hyperplasia

Oct 2017: LCIS diagnosed after excisional biopsy of 32mm lesion

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Nov 24, 2017 04:41PM Moderators wrote:

Hi-Risk-4BC…, thank you for sharing your experiences. We agree that a second opinion may be a good option. Sending you hugs NicolaSue!


To send a Private Message to the Mods: community.breastcancer.org/mem...
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Dec 31, 2017 06:03AM Mandycat wrote:

I thought the same thing about the estrogen levels being so low they were undectable so they might not be necessary to take the hormone therapy. Then I tried the armedex. I wasn't able to tolerate more than a few doses but I must still have enough estrogen to be helpful to my brain because my brain did not like being off estrogen. I think we do still produce enough estrogen to effect our outcomes so taking the pills will help some women avoid additional cancer but I was unable to do i

Dx 4/11/2017, Right, <1cm, Stage IA, Grade 2, ER+/PR- Surgery 5/1/2017 Lumpectomy Hormonal Therapy Arimidex (anastrozole)

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