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Topic: Anyone have signet ring cells? HER2 positive but LOW Ki-67?

Forum: LCIS (Lobular Carcinoma In Situ) — Just diagnosed, in treatment, or finished treatment for LCIS.

Posted on: Oct 11, 2019 08:57AM

cyathea wrote:

I was diagnosed with invasive lobular carcinoma with signet-ring features in my right and left breasts. From my online reading, it seems that signet ring cells are more commonly found with GI cancers. My MO said the signet ring cells are not important and that the HER2 status is what counts. Still, does anyone else have signet ring cells? What was your experience? Does anyone know whether signet ring cells are more likely with MBC?

I'm also interested to know if anyone else is HER2+ (meaning that the cancer is aggressive), but a low (5%) Ki-67 which would indicate that the cancer was slow growing. It seems like my BC is an oxymoron.

Since diagnosis, I developed a bone lesion, so I'm guessing that my cancer is probably more in line with the aggressive side of things than the Ki-67 would have predicted.

Dx 6/17/2019, DCIS/ILC, Right, 5cm, Stage IV, metastasized to bone, Grade 2, ER+/PR-, HER2+ (FISH) Targeted Therapy 7/31/2019 Perjeta (pertuzumab) Chemotherapy 7/31/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Chemotherapy 10/8/2019 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 10/10/2019 Herceptin (trastuzumab) Surgery 3/17/2020 Lymph node removal: Left, Right, Sentinel, Underarm/Axillary; Mastectomy: Left, Right Chemotherapy 4/15/2020 Other Radiation Therapy 5/31/2020 3DCRT: Breast, Lymph nodes, Bone Targeted Therapy Herceptin (trastuzumab)
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Oct 12, 2019 03:13PM leaf wrote:

I'm so sorry you are going through this.

You may want to post this on the invasive lobular carcinoma (ILC) forum. LCIS is not considered cancer; I haven't heard of anyone with LCIS (and nothing worse such as DCIS or invasive) have their HER2 or Ki-67 status measured. (I may be Very wrong, and I certainly haven't read most LCIS posts on this forum.)

I certainly don't know much at ALL about invasive breast cancer, but in a brief Pubmed search, I did find this Very Old study (from 1995) that from a quite small group (99 carcinomas), more signet cells had a worse prognostic outcome.

https://www.ncbi.nlm.nih.gov/pubmed/7802556

I imagine lots is not known, and don't know if this paper is an anomaly.

Best wishes.

Classic LCIS.If knowledge can create problems, it is not through ignorance that we can solve them- Isaac Asimov Dx 12/8/2005, LCIS, ER+/PR- Surgery 1/24/2006 Lumpectomy: Left Hormonal Therapy 7/15/2006 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Oct 17, 2019 07:58PM cyathea wrote:

Thanks for the info, leaf. I came across the same study in my research. I didn’t realize that I posted in the wrong forum group. I’ll try re-posting.

Dx 6/17/2019, DCIS/ILC, Right, 5cm, Stage IV, metastasized to bone, Grade 2, ER+/PR-, HER2+ (FISH) Targeted Therapy 7/31/2019 Perjeta (pertuzumab) Chemotherapy 7/31/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Chemotherapy 10/8/2019 Abraxane (albumin-bound or nab-paclitaxel) Targeted Therapy 10/10/2019 Herceptin (trastuzumab) Surgery 3/17/2020 Lymph node removal: Left, Right, Sentinel, Underarm/Axillary; Mastectomy: Left, Right Chemotherapy 4/15/2020 Other Radiation Therapy 5/31/2020 3DCRT: Breast, Lymph nodes, Bone Targeted Therapy Herceptin (trastuzumab)

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