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Oct 18, 2020 11:12PM
Oct 18, 2020 11:18PM
Yes, LCIS or PLCIS can indicate an increased risk of future invasive cancer, (and of DCIS.)
And we don't know if your PLCIS turned into your ILC. But it probably could have (which would require sequencing both samples, which I don't think can be done except in a science lab.) On the other hand, the ILC may have grown independently of PLCIS. We don't know how many spots of PLCIS or LCIS you had/have.
Yes, PLCIS can probably grow independently of ILC. There are people who have had simultaneously discovered IDC and ILC (1 case in this study https://pubmed.ncbi.nlm.nih.gov/30185420/).
They (scientists) can do clonal analysis, which looks at the mutations both in the LCIS (or PLCIS) and in the ILC. When they do this, sometimes they find the LCIS/PLCIS has mutations in common with the ILC, and sometimes they don't.
In this admittedly very small study, they looked at 9 patients that had LCIS and then subsequently (2-10 years later) found invasive breast cancer in the same breast. https://pubmed.ncbi.nlm.nih.gov/17380381/ They found 5 cases had ILC and 4 IDC. Two of the ILC cases were clonally related (meaning their LCIS and ILC had mutations in common) and in the other 7 cases they were not.
In this paper, they found Forty-two percent (18/43) of LCIS were found to be clonally related to synchronous DCIS and/or ILCs, with clonal evolutionary patterns indicative of clonal selection and/or parallel/branched progression.https://pubmed.ncbi.nlm.nih.gov/30185420/
What makes PLCIS/LCIS a risk factor for future invasive breast cancer is unknown. (We also don't know if the risk factor(s) for each are the same.)
In this paper https://pubmed.ncbi.nlm.nih.gov/33047861/ they found Four NCLCIS <PLCIS/FLCIS> developed ipsilateral recurrences: 2 NCLCIS, 1 IDC, and 1 ILC (50; 10-96 months). No breast event was reported in 24 pure CLCIS (60; 8-144 months). Invasive carcinoma with NCLCIS, unlike CLCIS, is always lobular type. Recurrences following NCLCIS are ipsilateral lobular tumors. <in this study>
There is obviously a lot we don't know about LCIS/PLCIS. In the studies that do exist, often there is controversy. But, eventually, if we let science take its course, we will know more.
Classic LCIS.If knowledge can create problems, it is not through ignorance that we can solve them- Isaac Asimov
12/8/2005, LCIS, ER+/PR-
1/24/2006 Lumpectomy: Left
7/15/2006 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)