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Topic: LCIS in Lumpectomy Path Report after MIC diagnosis on biopsy

Forum: LCIS (Lobular Carcinoma In Situ) — Just diagnosed, in treatment, or finished treatment for LCIS.

Posted on: Dec 2, 2020 09:23PM

Speckyrogers wrote:

Hi- New to site.

Strong family history of BC - Mom and sister BC survivors. Their diagnosis resulting in me having six month check ups with alternating Mammo and MRIs.

Right breast two biopsies. First fibrocystic changes; 2nd PASH.

Left breast - 10/6/20 Microcalcifications on 3D Mammo led to biopsy. Results showed Microinvasive Carcinoma with Lobular Features, ALH, and ADH. Genetic tests negative. MRI didn’t show any worrisome areas. Decided on Lumpectomy. Tissue showed no residual cancer but area of LCIS. Sentinel Node negative. I’m meeting with MO and RO next week for further treatment plan.

I’m wondering whether microinvasive cancer came from the LCIS or if LCIS on path is something completely different. BS didn’t think LCIS will change the treatment plan of radiation and hormone suppression therapy. I’m wondering if the oncologists will recommend further surgery because of multiple diagnoses.

Does anyone have similar diagnosis andor input?

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Dec 10, 2020 09:49AM leaf wrote:

There is no way of knowing, at least for sure, whether the microinvasive cancer came from LCIS or if LCIS on path is something clearly different. When they look at genetic analysis of tissues, for women that previously had 'just' LCIS then later or simultaneously detected invasive breast cancer, sometimes the LCIS was genetically related to the invasive cancer, and sometimes it was not. Normally, with LCIS only, the LCIS is found in multiple spots in a breast, and often in both breasts. (They know this because previous to about mid-1990, they routinely did bilateral mastectomies on women with LCIS and they could look at the mastectomy specimens.) We don't know how LCIS puts one at higher risk of breast cancer (in other words, the mechanism that LCIS increases breast cancer risk.) When women with 'just' LCIS go on to get invasive breast cancer, sometimes/often the invasive cancer is not at, but adjacent to, the previously known LCIS. The area that later became cancerous looks normal under screening.

I doubt if your LCIS diagnosis will cause additional surgery, unless there are suspicious areas that were not removed. At least half of the women with classic known LCIS only will never go on to get DCIS or invasive breast cancer. They can't remove 'all the LCIS spots' because they don't know where they are, unless perhaps they do bilateral mastectomies. But even bilateral mastectomies will not remove all breast tissue, any of which could contain LCIS.

When someone is diagnosed with LCIS on biopsy, they normally do an excision to see if there is something worse in the vicinity. They normally don't try to remove all of the LCIS because they don't have an idea where it is. Most LCIS is detected as an incidental finding when they do biopsies or lumpectomies.

Classic LCIS.If knowledge can create problems, it is not through ignorance that we can solve them- Isaac Asimov Dx 12/8/2005, LCIS, ER+/PR- Surgery 1/24/2006 Lumpectomy: Left Hormonal Therapy 7/15/2006 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)

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