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All TopicsForum: IDC (Invasive Ductal Carcinoma) → Topic: What does KI-67 number mean?

Topic: What does KI-67 number mean?

Forum: IDC (Invasive Ductal Carcinoma) — Just diagnosed, in treatment, or finished treatment for IDC.

Posted on: Nov 8, 2011 08:43PM

WaveWhisperer wrote:

I keep seeing additional information in the biopsy and pathology reports. What is KI-67 and what does the percentage number mean? Is a low number favorable or not favorable? How does it influence a doctor's recommendation for follow-up treatments after surgery?

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Nov 8, 2011 08:49PM SpecialK wrote:

WaveWhisperer - KI-67 percentages indicate the measurement of a protein that increases as cells divide, which is informative of the rate of cell growth.  A low number indicates slow growth, low is 10% or less, intermediate is 10-20%, high is 20% or above.  The KI-67 number is one of the tools used by oncologists to determine if chemotherapy may be appropriate.

Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, 2cm, Stage IIb, Grade 3, 2/14 nodes, ER+/PR+, HER2+ Hormonal Therapy 07/31/2011 Femara (chemical name: letrozole, class: aromatase inhibitor) Hormonal Therapy 06/19/2012 Arimidex (chemical name: anastrozole, class: aromatase inhibitor) Hormonal Therapy 07/17/2013 Femara (chemical name: letrozole, class: aromatase inhibitor) Targeted Therapy 02/16/2011 Herceptin (chemical name: trastuzumab) Surgery 01/20/2011 Reconstruction of my left breast Surgery 07/19/2011 Reconstruction of my left breast: Tissue expander placement Surgery 02/23/2012 Reconstruction of my left breast; Reconstruction of my right breast Surgery 12/13/2010 Reconstruction of my left breast; Reconstruction of my right breast Surgery 12/13/2012 Reconstruction of my left breast; Reconstruction of my right breast Surgery 03/06/2014 Reconstruction of my left breast; Reconstruction of my right breast Surgery 04/01/2014 Reconstruction of my left breast Surgery 11/12/2014 Reconstruction of my left breast Surgery 05/08/2014 Reconstruction of my left breast Surgery 10/31/2010 Mastectomy of one or both breasts: Mastectomy of my left breast, Mastectomy of my right breast; Reconstruction of my left breast: Tissue expander placement; Reconstruction of my right breast: Tissue expander placement Surgery 12/05/2010 Lymph node removal (also called dissection): Underarm (axillary) lymph node removal (also called dissection) , Lymph node removal (also called dissection) on my right side Surgery 12/20/2010 Reconstruction of my left breast Surgery 01/06/2011 Reconstruction of my left breast Chemotherapy 02/16/2011 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Nov 8, 2011 08:55PM WaveWhisperer wrote:

Wow, thanks for that quick and knowledgeable answer!!!

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage Ib, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 07/07/2013 Aromasin (chemical name: exemestane, class: aromatase inhibitor)
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Nov 8, 2011 08:58PM HeidiToo wrote:

Also, my surgeon at Memorial Sloan Kettering says they do not put much stock in it. It is only representative of the particular specimen grabbed in the biopsy--- not necessarily indicative of the entire tumor's agressiveness.

FWIW

" It's not the years in your life, but the life in your years." (Abe Lincoln) Dx 8/11/2009, IDC, 2cm, Stage IIa, Grade 3, ER-/PR-, HER2- Surgery 09/08/2009 Lumpectomy in one or both breasts: Lumpectomy in my right breast; Prophylactic (also called preventive) removal of the ovaries ; Reconstruction of my left breast: DIEP flap; Reconstruction of my right breast: DIEP flap Radiation Therapy 01/01/2010 Chemotherapy 10/25/2009 Cytoxan (chemical name: cyclophosphamide), Taxotere (chemical name: docetaxel)
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Nov 8, 2011 09:03PM weesa wrote:

This is the one feature of my path report I have never been able to figure out. My Ki-67 is 75%, pretty high. My mitotic rate is a 1. These to seem to contradict each other.

Sometimes I wonder if I am an old soul temporarily trapped in a breast cancer body. Dx 11/22/2002, IDC, 6cm+, Stage IIIa, Grade 2, 5/25 nodes, ER+/PR+, HER2- Surgery Lumpectomy in one or both breasts: Lumpectomy in my right breast; Mastectomy of one or both breasts: Mastectomy of my right breast; Lymph node removal (also called dissection): Underarm (axillary) lymph node removal (also called dissection) , Sentinel lymph node removal (also called dissection) , Lymph node removal (also called dissection) on my right side ; Reconstruction of my right breast: Latissimus dorsi flap Hormonal Therapy 08/22/2003 Femara (chemical name: letrozole, class: aromatase inhibitor) Radiation Therapy 06/13/2003 Chemotherapy 01/19/2003 Adriamycin (chemical name: doxorubicin), Cytoxan (chemical name: cyclophosphamide), Taxotere (chemical name: docetaxel)
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Nov 8, 2011 09:19PM SpecialK wrote:

weesa - my KI-67 was 43%, mitotic rate 1 - seems inconsistent to me too!

Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, 2cm, Stage IIb, Grade 3, 2/14 nodes, ER+/PR+, HER2+ Hormonal Therapy 07/31/2011 Femara (chemical name: letrozole, class: aromatase inhibitor) Hormonal Therapy 06/19/2012 Arimidex (chemical name: anastrozole, class: aromatase inhibitor) Hormonal Therapy 07/17/2013 Femara (chemical name: letrozole, class: aromatase inhibitor) Targeted Therapy 02/16/2011 Herceptin (chemical name: trastuzumab) Surgery 01/20/2011 Reconstruction of my left breast Surgery 07/19/2011 Reconstruction of my left breast: Tissue expander placement Surgery 02/23/2012 Reconstruction of my left breast; Reconstruction of my right breast Surgery 12/13/2010 Reconstruction of my left breast; Reconstruction of my right breast Surgery 12/13/2012 Reconstruction of my left breast; Reconstruction of my right breast Surgery 03/06/2014 Reconstruction of my left breast; Reconstruction of my right breast Surgery 04/01/2014 Reconstruction of my left breast Surgery 11/12/2014 Reconstruction of my left breast Surgery 05/08/2014 Reconstruction of my left breast Surgery 10/31/2010 Mastectomy of one or both breasts: Mastectomy of my left breast, Mastectomy of my right breast; Reconstruction of my left breast: Tissue expander placement; Reconstruction of my right breast: Tissue expander placement Surgery 12/05/2010 Lymph node removal (also called dissection): Underarm (axillary) lymph node removal (also called dissection) , Lymph node removal (also called dissection) on my right side Surgery 12/20/2010 Reconstruction of my left breast Surgery 01/06/2011 Reconstruction of my left breast Chemotherapy 02/16/2011 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Nov 8, 2011 10:04PM WaveWhisperer wrote:

Oh, dear, now there's one more term I'm not familiar with -- mitotic rate. What is it and where do I look for it on my biopsy or path reports???

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage Ib, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 07/07/2013 Aromasin (chemical name: exemestane, class: aromatase inhibitor)
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Nov 8, 2011 10:33PM SpecialK wrote:

wavewhisperer - kind of the same thing  - speed of cell turnover.  If your pathologist used the Nottingham score on your path report it is comprised of three parts:  mitotic rate, tubule formation and nuclear pleomorphism.  All three are given a score and that is what detrmines the grade of your tumor. 

Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, 2cm, Stage IIb, Grade 3, 2/14 nodes, ER+/PR+, HER2+ Hormonal Therapy 07/31/2011 Femara (chemical name: letrozole, class: aromatase inhibitor) Hormonal Therapy 06/19/2012 Arimidex (chemical name: anastrozole, class: aromatase inhibitor) Hormonal Therapy 07/17/2013 Femara (chemical name: letrozole, class: aromatase inhibitor) Targeted Therapy 02/16/2011 Herceptin (chemical name: trastuzumab) Surgery 01/20/2011 Reconstruction of my left breast Surgery 07/19/2011 Reconstruction of my left breast: Tissue expander placement Surgery 02/23/2012 Reconstruction of my left breast; Reconstruction of my right breast Surgery 12/13/2010 Reconstruction of my left breast; Reconstruction of my right breast Surgery 12/13/2012 Reconstruction of my left breast; Reconstruction of my right breast Surgery 03/06/2014 Reconstruction of my left breast; Reconstruction of my right breast Surgery 04/01/2014 Reconstruction of my left breast Surgery 11/12/2014 Reconstruction of my left breast Surgery 05/08/2014 Reconstruction of my left breast Surgery 10/31/2010 Mastectomy of one or both breasts: Mastectomy of my left breast, Mastectomy of my right breast; Reconstruction of my left breast: Tissue expander placement; Reconstruction of my right breast: Tissue expander placement Surgery 12/05/2010 Lymph node removal (also called dissection): Underarm (axillary) lymph node removal (also called dissection) , Lymph node removal (also called dissection) on my right side Surgery 12/20/2010 Reconstruction of my left breast Surgery 01/06/2011 Reconstruction of my left breast Chemotherapy 02/16/2011 Carboplatin (brand name: Paraplatin), Taxotere (chemical name: docetaxel)
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Nov 9, 2011 06:35AM WaveWhisperer wrote:

Special K, thanks for the additional info!

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage Ib, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 07/07/2013 Aromasin (chemical name: exemestane, class: aromatase inhibitor)
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Nov 9, 2011 02:13PM peggy_j wrote:

SpecialK wrote: If your pathologist used the Nottingham score on your path report it is comprised of three parts:  mitotic rate, tubule formation and nuclear pleomorphism.  All three are given a score and that is what detrmines the grade of your tumor. 

Thanks for posting this helpful explanation.

Dx 2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-