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All TopicsForum: IDC (Invasive Ductal Carcinoma) → Topic: What does KI-67 number mean?

Topic: What does KI-67 number mean?

Forum: IDC (Invasive Ductal Carcinoma) — Just diagnosed, in treatment, or finished treatment for IDC.

Posted on: Nov 8, 2011 06:43PM

WaveWhisperer wrote:

I keep seeing additional information in the biopsy and pathology reports. What is KI-67 and what does the percentage number mean? Is a low number favorable or not favorable? How does it influence a doctor's recommendation for follow-up treatments after surgery?

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage IB, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 7/7/2013 Aromasin (exemestane)
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Nov 8, 2011 06:49PM SpecialK wrote:

WaveWhisperer - KI-67 percentages indicate the measurement of a protein that increases as cells divide, which is informative of the rate of cell growth.  A low number indicates slow growth, low is 10% or less, intermediate is 10-20%, high is 20% or above.  The KI-67 number is one of the tools used by oncologists to determine if chemotherapy may be appropriate.

BMX w/ TE 11/1/10, ALND 12/6/10. Twelve additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ Dx 9/27/2010, DCIS, Stage 0, Grade 3
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Nov 8, 2011 06:55PM WaveWhisperer wrote:

Wow, thanks for that quick and knowledgeable answer!!!

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage IB, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 7/7/2013 Aromasin (exemestane)
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Nov 8, 2011 06:58PM HeidiToo wrote:

Also, my surgeon at Memorial Sloan Kettering says they do not put much stock in it. It is only representative of the particular specimen grabbed in the biopsy--- not necessarily indicative of the entire tumor's agressiveness.

FWIW

" It's not the years in your life, but the life in your years." (Abe Lincoln) Dx 8/11/2009, IDC, 2cm, Stage IIA, Grade 3, ER-/PR-, HER2- Surgery 9/8/2009 Lumpectomy: Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 10/25/2009 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 1/1/2010 Breast, Lymph nodes
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Nov 8, 2011 07:03PM weesa wrote:

This is the one feature of my path report I have never been able to figure out. My Ki-67 is 75%, pretty high. My mitotic rate is a 1. These to seem to contradict each other.

Sometimes I wonder if I am an old soul temporarily trapped in a breast cancer body. Dx 11/22/2002, IDC, 6cm+, Stage IIIA, Grade 2, 5/25 nodes, ER+/PR+, HER2- Chemotherapy 1/19/2003 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 6/13/2003 Breast, Lymph nodes Hormonal Therapy 8/22/2003 Femara (letrozole) Surgery Lumpectomy: Right; Mastectomy: Right; Lymph node removal: Sentinel, Underarm/Axillary, Right; Reconstruction (right): Latissimus dorsi flap
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Nov 8, 2011 07:19PM SpecialK wrote:

weesa - my KI-67 was 43%, mitotic rate 1 - seems inconsistent to me too!

BMX w/ TE 11/1/10, ALND 12/6/10. Twelve additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ Dx 9/27/2010, DCIS, Stage 0, Grade 3
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Nov 8, 2011 08:04PM WaveWhisperer wrote:

Oh, dear, now there's one more term I'm not familiar with -- mitotic rate. What is it and where do I look for it on my biopsy or path reports???

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage IB, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 7/7/2013 Aromasin (exemestane)
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Nov 8, 2011 08:33PM SpecialK wrote:

wavewhisperer - kind of the same thing  - speed of cell turnover.  If your pathologist used the Nottingham score on your path report it is comprised of three parts:  mitotic rate, tubule formation and nuclear pleomorphism.  All three are given a score and that is what detrmines the grade of your tumor. 

BMX w/ TE 11/1/10, ALND 12/6/10. Twelve additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 6/18/13-present. Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ Dx 9/27/2010, DCIS, Stage 0, Grade 3
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Nov 9, 2011 04:35AM WaveWhisperer wrote:

Special K, thanks for the additional info!

Lumpectomy 10/29/2011. TCx4 12/20;1/11;1/31;2/21/12. Started rads 3/19/12. Was in clnical trial testing 3-week course vs. standard 6-week course of rads. Took Arimidex for 2 years, now on Aromasin. Dx 10/14/2011, IDC, 1cm, Stage IB, Grade 3, 1/3 nodes, ER+/PR+, HER2- Hormonal Therapy 7/7/2013 Aromasin (exemestane)
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Nov 9, 2011 12:13PM peggy_j wrote:

SpecialK wrote: If your pathologist used the Nottingham score on your path report it is comprised of three parts:  mitotic rate, tubule formation and nuclear pleomorphism.  All three are given a score and that is what detrmines the grade of your tumor. 

Thanks for posting this helpful explanation.

Dx 2/2011, IDC, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2-