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Topic: Oncotype or Mammaprint on biopsied tissue?

Forum: IDC (Invasive Ductal Carcinoma) — Just diagnosed, in treatment, or finished treatment for IDC.

Posted on: Dec 4, 2020 08:27AM

arlva24 wrote:

Hi all,

I was just diagnosed with ER+/PR+/HER2- invasive ductal carcinoma. I'm still waiting for my surgery date but have been anxious to get more test results. Does anyone know if more genetic testing (Oncotype/Mammaprint) can be done off the core biopsy samples? I'm just worried about continuing to wait for results. Thanks in advance.

Dx 11/25/2020, DCIS/IDC/IDC: Tubular, Left, <1cm, Grade 1, 0/1 nodes, ER+/PR+, HER2-
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Dec 4, 2020 08:50AM Beesie wrote:

From what I've seen on this site, Oncotype or Mammaprint testing is sometimes done using biopsy samples but much more often is done using surgery tissue. I believe that a certain amount of tissue is required and I think in many cases there isn't enough viable tissue left from the biopsy sample after the IHC testing for ER, PR and HER2.

“No power so effectually robs the mind of all its powers of acting and reasoning as fear.” Edmund Burke
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Dec 4, 2020 01:57PM TwoForOneSpecial wrote:

Originally I was told the oncotype would be done from the biopsy tissue, but then it was decided to wait until there was a larger sample post surgery. The waiting is awful.

Good luck!

Diagnosis received the day after I turned 50. Happy birthday to me! Dx 8/26/2020, IDC, Right, 1cm, Stage IA, Grade 2, 0/1 nodes, ER+/PR+, HER2- Surgery 10/21/2020 Lumpectomy: Right Radiation Therapy 12/3/2020 Whole-breast
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Dec 4, 2020 02:23PM brittonkb wrote:

My Oncotype was performed using my biopsy tissue. In hindsight I wish my surgeon would have waited. My lymph nodes were clinically negative, but discovered 3 positive nodes with surgery. I think the Oncotype is run differently if node positive (up to 3 nodes). My oncologists were surprised the surgeon did it on the biopsy sample.

Dx 4/29/2020, IDC, Right, 4cm, Stage IIB, Grade 3, 3/13 nodes, ER+/PR+, HER2- (IHC) Surgery 5/19/2020 Lumpectomy; Lymph node removal: Sentinel Surgery 7/5/2020 Lymph node removal: Underarm/Axillary Chemotherapy 8/2/2020 AC + T (Taxol) Radiation Therapy 1/19/2021 Whole-breast: Breast, Lymph nodes
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Dec 4, 2020 07:05PM OCDAmy wrote:

My oncotype used my biopsy tissue.

Dx 2/2017, IDC, Left, 4cm, Stage IIB, Grade 2, 2/13 nodes, ER+/PR+, HER2- Surgery 11/14/2018 Reconstruction (left): Fat grafting; Reconstruction (right): Fat grafting, Silicone implant Surgery Lymph node removal; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy Arimidex (anastrozole) Surgery Reconstruction (left): DIEP flap Radiation Therapy Whole-breast

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