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Topic: Metformin

Forum: IDC (Invasive Ductal Carcinoma) — Just diagnosed, in treatment, or finished treatment for IDC.

Posted on: Aug 1, 2021 05:07PM

Waves2Stars wrote:

Does anyone take Metformin for BC? I already knew the connection of cancer and sugar/glucose, and I’ve avoided it until last year. I’ve read on pubmed info about it helping to control growth factors. I know I can do that with diet and exercise, but there is a history of diabetes in my family, and my grandmother was Native American, so I want to reduce that tendency as much as possible.

If you take it for BC, is it a trial, or off label?

DX @ 47. IDC 2 cm, Luminal B Dx 7/19/2021, IDC, Left, 2cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 9/1/2021 Lymph node removal: Sentinel; Mastectomy: Left; Reconstruction (left): Stacked DIEP flap Hormonal Therapy 9/20/2021 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Aug 1, 2021 05:16PM Olma61 wrote:

I think Metformin is part of the protocol that “Care Oncology” uses -

https://careoncology.com/

They repurpose prescription drugs to enhance your conventional treatment.

I think Jane McLelland discusses Metformin in her book “How to Starve Cancer” also.

Not sure if conventional oncologists or primary care physicians will prescribe, especially for someone who isn’t metastatic


10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Aug 1, 2021 06:24PM Waves2Stars wrote:

Thanks, I will look at the book and website!

DX @ 47. IDC 2 cm, Luminal B Dx 7/19/2021, IDC, Left, 2cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2- (FISH) Surgery 9/1/2021 Lymph node removal: Sentinel; Mastectomy: Left; Reconstruction (left): Stacked DIEP flap Hormonal Therapy 9/20/2021 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Aug 1, 2021 06:57PM AliceBastable wrote:

I was on Metformin when I got cancer, and I'm sure I'm not the only diabetic in the world on Metformin who got cancer. I've only seen it used adjunctively in a few Stage 4 patients.

Endometrial cancer 2010, basal cell multiples, breast cancer 2018, kidney cancer 2018. Boring. Hope it stays that way. Dx 5/2018, ILC, Left, 2cm, Stage IA, Grade 1, 1/1 nodes, ER+/PR+, HER2- Surgery 7/11/2018 Lumpectomy: Left; Lymph node removal: Sentinel Surgery 8/8/2018 Radiation Therapy 10/29/2018 Whole-breast: Breast, Lymph nodes
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Aug 1, 2021 07:06PM SpecialK wrote:

I am not diabetic, and have high-ish normal glucose as a result of having previously been on Lipitor, normal A1C, and my oncologist has prescribed Metformin for me for the breast cancer prevention benefit based on studies he has read about it. Same thing with low-dose aspirin. My primary care (military hospital) would not prescribe Metformin even though they are also aware of the same studies,because I did not fall into the parameters for diabetes or pre-diabetes.

BMX w/ TE 11/1/10, ALND 12/6/10. 16 additional surgeries. TCHx6 2/17-6/2/11. Herceptin until 1/19/12. Femara 8/1/11, Arimidex 6/20/12, back to Femara 2013-2018. Dx 9/27/2010, DCIS, Stage 0, Grade 3 Dx 9/27/2010, IDC, Right, 2cm, Stage IIB, Grade 3, 2/14 nodes, ER+/PR+, HER2+ (IHC)
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Aug 1, 2021 07:15PM Trishyla wrote:

I use both metformin and desloratadine for their potential anti cancer properties. My primary care, who is an Osteopath, prescribes them for me. She was hesitant when I first brought it up, but when she did her research she felt that since their side effects are so minimal it was worth trying them. So far I've had no adverse effects.

I've also just started taking DIM, with her approval, in lieu of an aromatase inhibitor. I tried the AI's, but the side effects were too severe for me to continue.

Do they work to prevent a cancer reoccurrence? Who knows. But for me it's worth giving it a shot.

Good luck.

Trish

Dx 8/30/2016, IDC, Left, 1cm, Stage IIA, Grade 2, 1/2 nodes, ER+/PR+, HER2- Dx 8/30/2016, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Dx 9/6/2016, IDC, Left, 1cm, Stage IIA, Grade 2, 1/2 nodes, ER+/PR+, HER2- Chemotherapy 9/28/2016 AC + T (Taxol) Surgery 4/4/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 8/4/2017 Xeloda (capecitabine)
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Aug 1, 2021 08:50PM AliceBastable wrote:

I hate taking Metformin so I guess I can't understand anyone wanting it based on "MAYBE it will do X." I can just tolerate the 500 mg once a day. My A1c crept up at one point and my doctor raised the dose to 750. I took it ONCE and was rewarded with uncontrollable, explosive diarrhea. When I let my doctor's office know, they said, "Oh, yeah, that happens with some people." WTF? I had to stop altogether and work my way up to the 500 mg again with partial pills. Just letting you know that like every drug, you need to be aware of possible side effects.

Endometrial cancer 2010, basal cell multiples, breast cancer 2018, kidney cancer 2018. Boring. Hope it stays that way. Dx 5/2018, ILC, Left, 2cm, Stage IA, Grade 1, 1/1 nodes, ER+/PR+, HER2- Surgery 7/11/2018 Lumpectomy: Left; Lymph node removal: Sentinel Surgery 8/8/2018 Radiation Therapy 10/29/2018 Whole-breast: Breast, Lymph nodes
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Aug 1, 2021 10:36PM KIDI919 wrote:

Trishyla, What is DIM?

Dx 9/17/2019, DCIS/IDC, Left, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (IHC)
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Aug 1, 2021 11:10PM Olma61 wrote:

Good to know some doctors are willing to work with us and be flexible on things like this 👍🏼

Alice, damn, that sounds rough.


10/30/2017 Xgeva for bone mets 5/31/2018 Taxol finished! "If one just keeps on walking, everything will be all right” - Kierkegaard Dx 8/3/2017, IDC, Right, 2cm, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2+ (IHC) Targeted Therapy 10/28/2017 Perjeta (pertuzumab) Targeted Therapy 10/28/2017 Herceptin (trastuzumab) Chemotherapy 10/30/2017 Taxol (paclitaxel) Hormonal Therapy 5/14/2018 Arimidex (anastrozole) Radiation Therapy 5/30/2019 External: Bone
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Aug 2, 2021 12:14AM BettyMorgan wrote:

I take Metformin for insulin resistance. Before I was diagnosed with bc

Dx 6/14/2021, DCIS/IDC: Papillary, Left, 6cm+, Stage IIIB, Grade 3, 0/4 nodes, ER+/PR+, HER2- (FISH) Surgery 7/7/2021 Lymph node removal: Sentinel; Mastectomy: Left Surgery 7/19/2021 Lumpectomy: Left Chemotherapy 8/18/2021 AC + T (Taxol) Hormonal Therapy Radiation Therapy
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Aug 2, 2021 12:38AM Trishyla wrote:

DIM is a supplement, KID1919, made from basically the active ingredient in cruciferous vegetables like broccoli and brussels sprouts. It is supposed to act much like an aromatase inhibitor, but with far fewer side effects. It's been paired with Tamoxifen in a couple of clinical trials to great effect.

It's available without a prescription at vitamin stores and on Amazon.

Dx 8/30/2016, IDC, Left, 1cm, Stage IIA, Grade 2, 1/2 nodes, ER+/PR+, HER2- Dx 8/30/2016, IDC, Right, 1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Dx 9/6/2016, IDC, Left, 1cm, Stage IIA, Grade 2, 1/2 nodes, ER+/PR+, HER2- Chemotherapy 9/28/2016 AC + T (Taxol) Surgery 4/4/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 8/4/2017 Xeloda (capecitabine)
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Aug 2, 2021 12:53AM KIDI919 wrote:

Trishyla , thanks! I am looking at supplements...sick of the SE from Al. I know all supplements don't agree with everyone, just like drugs. But it would be nice to half the dose of Al's.

Dx 9/17/2019, DCIS/IDC, Left, 1cm, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2- (IHC)
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Oct 10, 2021 02:43PM purple32 wrote:

Anyone talking desloratadine - can you give me the MG dosage ?

Many Thanks!

BILAT LE! from 5.12.12.LX DX 3/2012 IDC <1 cm stage 1 GR 1 ( 0/2 nodes) ER PR pos HER2- RECURRENCE same breast Jan 2020 LX FEB 2020 . NO rads or hormones. Dx 3/2012, IDC, Left, <1cm, Grade 1, 0/2 nodes, ER+/PR+, HER2+ Surgery 5/1/2012 Lumpectomy: Left
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Oct 10, 2021 02:44PM purple32 wrote:

AliceBastab Did you ask your DR for EXTENDED RELEASE metformin>
Has anyone tried BERBERINE supplenent for glucose control ?

BILAT LE! from 5.12.12.LX DX 3/2012 IDC <1 cm stage 1 GR 1 ( 0/2 nodes) ER PR pos HER2- RECURRENCE same breast Jan 2020 LX FEB 2020 . NO rads or hormones. Dx 3/2012, IDC, Left, <1cm, Grade 1, 0/2 nodes, ER+/PR+, HER2+ Surgery 5/1/2012 Lumpectomy: Left
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Oct 11, 2021 07:56AM Spookiesmom wrote:

Oh yeah, diarrhea is a known se. I was rx that when first dx with diabetes. Not a good med when you’re a school bus driver. Tried with food, extended release, nope. It’s a great diabetes med if you can tolerate it, for cancer? Not so sure.

First time IDGgrade 3, stage 3. Second time, found lump myself. That made me stage 4. Dx IDC, Stage IIIA, Grade 3
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Oct 11, 2021 03:54PM emotionalpond wrote:

I've been in metformin for about 12 years for insulin resistance. And am still on it. I take 2000 mg a day. 2 pills at lunch and 2 pills at dinner.

Dx 2/8/2021, IDC, Left, 1cm, Stage IIA, Grade 1, 3/16 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 4/2/2021 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 7/7/2021 Lumpectomy: Left; Lymph node removal: Sentinel Surgery 7/25/2021 Lymph node removal: Left, Underarm/Axillary Hormonal Therapy 8/30/2021 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 9/7/2021 Whole-breast: Breast, Lymph nodes

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