Oncotype vs mammaprint
I have:
2.2cm idc
Er 40%, pr >90% (surgical pathology)
single gene score of 9.5 er and 8.9 pr on the Oncotype DX (strong positive)
Her 2 +2 ihc, fish negative, oncotype her 2 gene score 9.1 (negative)
Grade 1 (mitotic rate 1)
Ki67 5-7%
Node negative, snlb took out 6
No lvi (mastectomy)
Dcis present
Oncotype 11 with 3% distant recurrence risk in 9 years
I read someone in the forum had conflicting result. High mammaprint but low oncotype. Now i'm worried what if i fall in high risk on mammaprint?
I asked chatpgt, it's certain that with all my low numbers (esp low ki67 and mitotic rate of 1) will correlate with mammaprint low risk as they focus more on profileration of tumor cells. Whereas oncotype rely more on er/pr receptor (the stronger, the lower onco score)
I'm already 1 month on lupron and 2 weeks of aromasin. Plan to take for 5 years then reasses. Should i do mammaprint just to make sure?
Comments
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Hi @mollybocil, In general medical tests are done if the results might change the treatment. The mammaprint does not provide any additional information and treatments like CDK4/6 inhibitors are not recommended for early stage grade 1 breast cancer with a low ki-97 score. It is unlikely that a mammaprint result would alter what you are doing.
The Breast Cancer Index that assesses whether another five years of estrogen blockers might be beneficial would be a useful test to get as you are coming up to the five year mark on estrogen blockers. Eating a healthy diet, limiting alcohol and exercising regularly have been shown to reduce recurrence by about 50% so that is well worth doing. I hope that you, I and everyone else remain cancer free but there are no guarantees even if we do everything we possibly can. All the best.
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Hi yes thank's maggie.
But if mammaprint turn out to be on the higher risk, i can do chemo to reduce risk
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The mammaprint does not directly predict whether chemo would be beneficial ; it just provides a recurrence risk. It can be used for ER- tumors whereas the Oncotype cannot. You can always ask your oncologist for their opinion on this.
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Hello Molly, your tumor's favorable biology doesn't seem to indicate that you would likely need to personalize treatment decisions as much as others. It's my understanding Mammaprint assays are data-driven. Maggie gave you some good comments.
Do you feel that you need to tailor any specific treatment strategy?
BluePrint assays give people molecular subtyping info, if you're interested in that. It also assesses specific gene expression signatures and their signal pathways, such as whether the tumor is Basal subtype, Luminal‐A or Luminal-B, and HER2‐type.
Explained another way, Mammaprint looks more at proliferative signaling, genome instability and any metastatic features such as genes associated with invasion, angiogenesis and stromal activity.
If a tumor's grade was low and its mitosis level was favorable, so the proliferation probability would most likely be low. Hormone therapy alone would likely be recommended in those cases.
Here's a link and hoping you continue to have easy, peaceful healing. Best wishes.
MAMMAPRINT VS. ONCOTYPE COMPARING BREAST CANCER TESTS
July 24, 20252 -
Grade 1, clean nodes, OncotypeDX 11? Low-risk. No chemo. Not only wouldn't it reduce your risk, it wouldn't even work on such slow-dividing cells. I take it you're pre-menopausal since you're on ovarian suppression to enable you to take an AI. Even so, you wouldn't even be intermediate risk with an Oncotype score below 16 (nowadays, for postmenopausal women, 20). Stick with the 5 years of the endocrine therapy combo and then reassess with your MO.
I wouldn't trust ChatGPT as far as I could throw it (virtually, of course). Dr. Google is similarly untrustworthy. Go with your oncologists' advice, get a second opinion if you want one (but you likely don't need one).
Heal well, and it'll be safe for you to "keep buying green bananas." (You've got a great prognosis).
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Thx chisandy ❤️
I asked 2 oncologist, my breast surgeon and onco radiologist. All said no chemo and i am in very low risk. But that what ifs keep creeping up my mind :( i have anxiety disordee. All my bc group members have chemo, i'm like the only one who doesn't, so i feel undertreated s
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Your group members had more aggressive cancers. Don’t pine for conformity. We all have the “what if?”s. It is what it is and not worth obsessing over it, keeping you from living your life.
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