Penn SURMOUNT & ABBY clinical trials

Hi there — thank you so much for sharing this, and wow, you have been through so much with incredible strength. ❤️ Two separate triple-negative diagnoses and all that treatment…that’s a lot, and it makes complete sense that you’d be looking toward the future and wanting to connect around research opportunities.

Clinical trials can be such an empowering way to access new approaches and help move the field forward, especially for TNBC and BRCA1+ patients. It’s great that you’ve already reached out to the study teams with questions — that’s exactly the right first step.

Just a quick note: the Penn “Surveillance” study is a screening trial looking for tiny hidden cancer cells in the bone marrow (DTCs) in people at higher risk of recurrence, regardless of subtype. The ABBY trial is the treatment study that follows, using pills like abemaciclib (more commonly used in HR+ breast cancer) with hydroxychloroquine to try to eliminate those cells — so it may not be TNBC-specific, but worth asking the team about eligibility.

While we may not have many members enrolled in these exact trials yet, we hope others considering trials will chime in. Please keep us posted on what you learn. 💗

I'm thinking that a doctor could prescribe either the Everolimus or hydroxychloroquine or both for off label (these are already FDA approved) use after treatment ends and the bone marrow is positive for DTC's.