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High dose estrogen therapy for breast cancer


The use of high-dose estrogens for the treatment of breast cancer - PubMed (


Estrogens are known to stimulate the growth of breast cancer but they are also an effective treatment for this disease (this has been termed the 'estrogen paradox'). The fact that estrogens can be an effective treatment for breast cancer is something that has almost been forgotten, whereas the fear for estrogens remains. This paper reviews the use of estrogens for the treatment of breast cancer and identifies possible applications. The data summarised in this review demonstrate that high-dose estrogens are effective for the treatment of advanced breast cancer, both as first-line treatment as well as for treatment after occurrence of endocrine resistance to TAM and AIs. Essential for efficacy is an extended period of estrogen deprivation before the tumour is subject to estrogen treatment (the gap hypothesis). Research on the mechanism of action has shown that apoptosis induced by estrogens is regulated via the estrogen receptor and growth factor signalling pathways. High-dose estrogens have a negative safety image, especially in terms of side-effects and increased rates of cardiovascular disease, but the safety data reviewed in this paper do not give rise to major concerns. Taking into account their side-effect profile together with their observed clinical efficacy, high-dose estrogens should be considered a valuable alternative to chemotherapy in selected patients.

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The use of high-dose estrogens for the treatment of breast cancer (


  • savaloko
    savaloko Member Posts: 30
    edited May 2022

    It's very interesting and makes sense. This is obtained if letrozole is taken constantly, then the tumor adapts to it, so there is little estrogen. And if you throw estrogen into the body, will Letrozole start acting again? Is that how it works?

  • husband11
    husband11 Member Posts: 1,287
    edited May 2022

    About 10 years ago we got a consultation with an Oncologist at Mayo Clinic, and he said that they used to use alternating estrogen deprivation (presumably from an AI like letrozole) with high estrogen, stopping when they saw progression. For some women, this strategy works for a while.