Verzenio

karecope

Taking verzenio ..having brutal side effects

vlnrph

Ask about a dose reduction. I had 2 and stayed on it for 4 years. Took FiberCon tablets for diarrhea control.

karecope

Is it still effective taking 50mg 2x a day

That seems to be the best tolerated for me

libelfreezone

Yes, 50mg is still effective. Here's an excerpt from an article about dosage. You should feel confident that this excellent pharmaceutical is doing its job even at 50mg.

From the link below:  Exploratory analyses to investigate the impact of dose reductions on efficacy were conducted. Across the three patient subgroups as defined by relative dose intensity, the estimated 4-year IDFS rates were generally consistent. In the time-dependent Cox proportional hazard model, the effect of abemaciclib was consistent at the full dose compared to being reduced to a lower dose. These analyses showed that the efficacy of adjuvant abemaciclib was not compromised by protocol-mandated dose reductions for patients with node positive, hormone receptor positive, human epidermal growth factor 2-negative, high-risk early breast cancer.  [...]  It has also been established that abemaciclib dose modifications improve tolerability without negatively affecting progression-free survival (PFS) in the metastatic breast cancer setting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11053007