BRCA2 gene mutation of uncertain significance.
Hello everyone,
I have been diagnosed with Stage 2 BC recently. Got my genetic report yesterday.
I have got a finding of BRCA2 Variant of uncertain significance c.9307A>G and MSH6 VUS c.943T>A
Anyone with similar mutation?
I have a family history of breast cancer in mother and sister. Genetic testing not done in them.
Original Dx: Feb 2026 ER PR+ and Her2 Neg, Grade 3 IDC, Stage 2a. On Letrozole now.
Comments
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I was diagnosed in 2022 and had a VUS of MSH6. I was worried because my father died of colon cancer, and MSH6 is a colon cancer gene. However, just this year, I received a letter from Myriad that my variant has been determined to be benign. More than 90% of variants are ultimately determined to be benign, it just takes a while for all the testing to be done, especially if it's uncommon.
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