ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM), and VUS (variants of unknown significance)
These Breastcancer.org links may offer helpful information: All about Genetic Testing: Genetics as a Risk Factor Genetic Testing as part of your Pathology Report What to do with your genetic test results Variants of Unknown Significance (VUS) Learning about your family background Genetic testing facilities and cost…
So I’m wondering how many of us here have the Axin2 gene? I have it with a variant of unknown significance. But my breast cancer surgeon told me years ago that they are learning new stuff all the time, unlearning other stuff and there is still a lot they still don’t know about breast cancer. Just curious how many of us…
anyone else have a DDX41 gene mutation and considering chemotherapy? I was just told I have this mutation and it can increase my risk of developing leukemia. I am concerned about starting chemo as this may increase risk of leukemia later on. This seems to be a “newer” discovery with genetic testing so wondering if anyone…
So my Mum had peritoneal cancer and found out she had the BRCA2 alteration. That's how I have just found out that I have inherited it through genetic testing. We have no history of breast cancer in the family as far as we know, however the Dr's told my mum that they could see that her cancer had developed from her ovaries…
Breast Cancer Survivors With BRCA Mutation Have Higher Risk of Second Cancer Jan 16, 2025 Risks were higher for a new cancer in the opposite breast, as well as ovarian, pancreatic, and prostate cancers. Read more…
I just received my genetic test results and I have the above variant which is known to cause all different types of cancers the most concerning as a micro papillary form of breast cancer. Has anyone else received this and also had multiple biopsies and scans due to an area of concern?
I was at my gastroenterologist last week. He passed on the following news adding that this is the first time (praticing over 30 years) that he has ever seen a risk being removed from guidelines. In August of this year, the National Comprehensive Cancer Network (NCCN) guidelines removed the warning that a CHEK2 mutation…
Hello, I was first diagnosed in 2015 with early stage IIb. I had genetic testing done at the time and was negative for all mutations including BRCA1 and 2. I had a recurrence in 2022 and I had the Caris test done on the tumor and again no BRCA found. Just within the last month I had a PET scan turn up some swollen lymph…
Hello I am new here, Our 45-year-old daughter died on May 14th of this year from triple negative breast cancer that metastasized to her brain and though a tumor was removed, it came back immediately and killed her. Unfortunately, family members knew back in 2020 that she should be tested for the RAD51D variant that had…
Hi, I keep reading studies online that refere to "brest cell lines", for example: MDA-MB-231, MDA-MB-468, MCF-7, and T-47D I can't understand what that really mean...if they actually matter, how do i know what cell line i have, if it is even important to know for the therapy choice. Do anybody know what I'm talking about…
Breast Cancer After Childbirth and Survival in Women With BRCA Mutation Jul 15, 2024 Does being diagnosed with breast cancer after giving birth affect survival? Read more…
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