INSOMNIACS place to talk in the wee hours
Comments
-
0 -
Susieq, what if, they think you are spending as much time away b/c you are tired and they are trying to give you your rest time. Maybe they didn't ask you up b/c they figured you would come up when you were ready. Have a cup of coffee and talk. I'll lay odds that you will find out everyone's trying to give the other space and not trying to put pressure on. when you all would like to be together more.
0 -
I couldn't find the beginning of the discussion on range of motion after mastectomy. Before my BMX I searched. As of 2009, I couldn't find anything that gave a decent reason for reduced or restricted motion after surgery.
I did full range of motion at 6 am the next morning.
Remember the surgery was started in the late 1800's. Even up till the late 1950's the standard of care was in bed for every so long--days and days after anything. Movement of limbs after surgery where a limb was perceived to be involved or there was direct involvement, was severely limited. That's why they're were so many complications after surgery. Most here can remember talk of relatives having pneumonia, blood clots, long recoveries b/c of the lack of getting up and moving, and imbs that never quite worked right after surgery.
What happened starting with WW2 and polio epidemics, lot's of things were learned about range of motion and early ambulation. Orthopedics, first of all made many advances b/c of wars. Lot's of other services--cardiovascular, genitourinary(men), neuro, plastics all made great advances b/c of wars and care of soldiers. Then orthopedics continued to make huge strides in the 70-90's about how fast to get things moving on extremities with the Totals--hips/knee/shoulders. In the late 80's passive range of motion machines were applied in the recovery room for total knees. For an ortho doc from a couple of decades earlier that would have been consider radical.
What I think happened with mastectomies after the modified radical mastectomy was introduced was that range of motion was never studied. It remained the same as it was in the late 1800's. They're wasn't a single study that I could find.
Since I worked in surgery, recovery, and surgery floor with both ortho and general patients my conclusion was that general surgeons(BS)&PS's never questioned that part of the treatment. Whereas, orthopedics was driven by immobility problems that had to be solved. Lack of range of motion for a woman wasn't realized to be the debilitating problem it is. General surgeons just didn't see the patient the way the ortho docs saw their patients. Women did what their docs told them. It's only been in the last few decades that women were listened too. Sounds harsh, but it was true. Docs were gods and you didn't question God.
Hence my arms were up at 12 o'clock position first thing in the am after BMX. Never a deficit.
I asked the Mods a few years ago to try and get some one interested in doing a study. I haven't revisited the subject. If they or anyone else has done one.
0 -
Shep this is a link to the Hot Flash Forum. I suggest that you start at page one. They're was some pretty decent research done in the first 30 pages.
https://community.breastcancer.org/forum/78/topics/770796?page=1
Mags, Yay room's almost done, Same with you too , Lookie. Junie and Smarrty nice sewing.
0 -
Update...
I joined the squishy side today!! It was an Ambulatory Surgery Center this time and it was a huge improvement from where I was for BMX! There at 6:30 am and discharged feeling decent by 11 am. Of course we had to get up at 4 am and I wasn't done with my pre-surgery To Do List.....last minute Annie that's me....so I laid down after 2 am. Two hours sleep and other that during anesthesia, I haven't been able to sleep all day. That means I'll sleep tonight....right? This was nothing like my BMX....this pain I can manage. Not doing jumping jacks LOL, but I'm getting by.
Sending prayers and warm wishes to everyone here. And take a momment to Be Happy...
Cyber hugs....
0 -
Susie I just read page 1195. See I was right LOL. Damn I shoulda made a bet.
0 -
Annie oh nice you sound good. I love that video
Junie sorry you feel sopunk
Shep I got bored with the AC search went thrifting. I'll bring back a couple of links I worked on that has some stuff on SSNRI's--Cymbalta. There is some overlap.
https://community.breastcancer.org/forum/102/topics/826526?page=1
https://community.breastcancer.org/forum/136/topics/839123?page=1
Shep which Windows do you have?
//////////////////////////////////////////////////////
Loving everyone's pic
0 -
Susan3 (googly eyes) SIGH1!1ELEVENTYONE1212! ISSA BEBE!
0 -
Found these at Goodwill. 39 or 59 cents ea. R.c 42$ ea. Choke!. Absolutely, wonderful, but could hardly tell with the dirt. Not long to find them. Val St. Lambert, Miterrand pattern from Belgium. pattern is old, but was done for a very long time. It's cut glass for the bowl and blown mold for the stem. I thought it was too busy, but had a wine in one after I found out they were elite. The balance is wonderful. Hope I find more, not likely, but will snatch them up. You can't see it well, but it has a bubble in the stem. Very unusual. The expense is b/c of the cut glass.
Imperial glass, Candlewick pattern, cream and sugar without the plate. 39 or 59 cents ea 17$ at r.c. Jumps to 69$ with glass plate.
Daisy and button pattern, Imperial. 1$ or 1.99. No R.c price. Pattern not showing well. I love pedestal plates. So, fun to have different heights. I recently learned that if you want the cake plate to show, don't get a ribbed or colored dome. Domes under 8$ are a steal.
Artesia by Block. Has a chip, trying to grind down.
The blue one.
:0 fun fun Missed a few things Oh well.tired
Shep no I haven't found that platter. I give them so many hours and then, I let it go. Often, I end up finding things later looking for something else.
0 -
my moms dog died today
. With her Alzheimer's I don't know how this is going to play out. She wasn't emotional, don't know what tomorrow will look like. She said my brother wasn't doing well. He is looking for another dog. If he gets a puppy...oh boy. He isn't home all day. Not going to be good. But I don't exist to him anymore, won't talk to me at all, even when it pertains to mom. Sad he's like that, but diagnosed depression and narcissistic personality disorder.. My mom won't know what to do with a puppy. Oh well, I guess poop and pee in the house isn't the worst thing that could happen...right ??.I leave Michigan tomorrow and go home. So sad. But hubby needs me home...and gotta go to chemo. My dog had to have an abscess lanced while I was gone. Pretty traumatic for hubby...she was bleeding out the back end...but all ok now. She is 15. I need to be home to cuddle with her too. Right now I need 2 if me!
And I need to rest!! Wow what a week. The kids have 4 weeks go before they move...so we all need to rest up.
Night night all
I need to catch up on all you guys!!! I will read up during chemo rest!!
0 -
Well, here I am again, just spent time catching up. I've been down the last two days with abdominal cramping, alternating c & d, screamy meemies pain. Started as I got out of the shower yesterday and went to pain level of 10 within minutes. It's always in the same spot, lower left, nothing eases it until it turns loose and then it comes and goes. I had a lot of this during chemo until MO put me on bentyl, but I stopped after chemo, maybe need it again. It's better tonight but still tender.
And that nasty old sebaceous cyst on my back has popped up again and hurts like the dickens. They knew they didn't get the whole sac out but they thought they got enough. Guess not. Doc says she'll order an antibiotic & see if that helps.
I had switched to the new iPad dh got me (less memory but has a data plan instead of just wifi) so I had to move everything over, rearrange my pics, etc, and then none of my passwords carried over.
The new room is a pale butter yellow, like the color of heavy cream, and a satin so it has reflectivity to it. I'll be painting in oils, if it's ever finished and if we find my easel and palette. Dh says they're not in the attic and I've been too sick to look.
*Waves to everyone* I'll try not to be a stranger. ("Stranger than what?" Rose wants to know.)0 -
Mags, sorry you are battling the gut issues. No fun, I had 1/3 of my colon removed in 2011. The pain from diverticulitis was debilitating. Hope it gets better soon.
Susan, ah.....HAPPY for you, the family. She is a doll baby. Hunk of love. Nothing better than a baby girl to care for, hold. Safe travels home.
Sas, love all the glass, especially the Imperial with the little bubbles on the rims. I have some very small dessert type dishes of those. I serve sorbet or sherbet in them if entertaining. Which, is really really difficult now.
I had my 3rd infusion of Taxaterrible on Tuesday. Neulasta on Wed. Chemo always sucks, but this is easier than the Red Devil ( AC ). I am grateful for that. Trying to read & keep up, not real successful, but I enjoy everyone's chit chat.
0 -
my DGS, Nick, has posted 2 video of him walking. I can't get a copy. So I asked him for a picture, so when I get it I'll post. Looks very bionic! He said that it makes his butt hurt.
because he is above the knee, the socket runs the full length of his stump. Doc says it will take time, new muscles and callus to get it comfortable. He moves really smooth with it already, just using a cane. Mags, sorry for the C & D. Hope it improves quickly.
Susan, safe travel home, glad your dog is doing well. Elana is so sweet.
Queenie, is that code?
Yes, lover, we'll do Vietnamese food next time. Don't think I've tried that before.
Annie, welcome to the squishy side. Do take it easy. If it pulls when reaching then don't. I don't remember any restrictions with the 1st 3 sx, but with the last one, I wasn't allow to use my arms much for the first 2 weeks. I played t-Rex. Be good to yourself. I never had any problems with my shoulders freezing up
Night all, hope everyone gets some shut eye
0 -
Susan beautiful pics. Not just Elena either - Claire has such beautiful brown eyes.
Sorry about your Mom and brother.
Love to all. XXX
0 -
Shep meant to say something about the docs and their excitement about Genelex/YouScript. The young ones are excited. The old docs glaze over. I ran into the Onc nurse navigator at my old hospital. She was Greg's nurse when I was trying to use Genelex and get pharmacy cooperation for evaluating his drugs. She said they use Genelex all the time. We didn't have the time to check extent, but it was cool.
I think I said I found Genelex in Jan. 2010, trying to search about drug interactions after Greg's first chemo was so negative. MO's reaction was "I don't even know that stuff". He got on board though.
The MO's admission orders for drugs at each admission was "Drugs per wife". If it was a different nurse they'd get all bent out of shape "We can't do that!". It's like "Relax, I'll give you the drugs except the chemo drugs and then you call the MO for orders." I based used on what was not bumping into each other and what could safely be interrupted for a few days. Like Coreg was changed to Metoporol b/c it used 2D6 only. Coreg used multiple paths that his chemo used. They're were a slew of drugs I manipulated that way.
I still have all the papers cross referencing his drugs with each drugs metabolism paths. His drugs were all bumping into each other. If you saw the initial software for Genelex, it was a hoot. Little did I know I found the only company doing what they were doing in the world.
But I didn't have the advantage of Greg's genetics. I had to make decisions based on written material. Even his insulin. That was the scariest. His insulin needs dropped like crazy with chemo. No one had an explanation. He would go from needing 70 units intermediate twice a day to it being risky with any or a few units while on chemo. I'll tell you, I was shaky when the nurses would ask "How much insulin and what type do you want given?" But God was with me. From the time I took over his drug management, he did better.
Can't wait until you plow through the 2D6 thread and we can get it active maybe. Their were lurkers aplenty, but few posters. You can tell I was talking to the lurkers allot.
If your 2C19 is ultra metabolizer, what is your VKROC1?
0 -
Mags, Ask doc for script for Silver Alginate. It's a collidiol(sic) silver impregnated super absorbent dressing. It's very expensive 50$ a package. But cut well to wound size, one sheet can last along time. It was always my go to dressing. In my early exposure to it I saw it take some nasty nasty wounds and turn them around. If silver alginate is not an option b/c of price ask for a Wound Care Certified doc or nurse eval and treatment options, if it's not going to get cut out. Cyst walls will always(almost always) regrow. Localized management is better than systemic unless the site is showing definite infection with infiltration into local tissue. Then antibx's are needed.
"Screamy meemies pain" is a concern(big safety issue)............I think it was HI1 that mentioned Diverticulitis as a problem. Look at the first page of the Constipation thread. I wrote a thing.
0 -
Hi1 glad to see you here, chemo---anything as long as they work. Praying. I forgot to put the pattern on the Imperial. It's candlewick. It was one of Imperials most successful. Send me your address and I'll send the C&S. I'll look for a few weeks. I'm always amazed how things start popping up when I start looking for them, and I may have not seen them in ever so long.
0 -
Okay, this is crazy............looking for cobalt for Jazzy. Walked around a corner at Goodwill 6 cobalt glasses and 6 lowballs --"Oh Shit" Another lady near me started laughing. I have never found that much cobalt at one time except for that stash three weeks ago. My own collection of glasses was one or two at a time. AND never 59cents a glass. Cobalt is usually the premium price of 2$-7$. I'm so weird, LOL. Hard to tell origin, but color and shape is right. Mexico and China have been ripping off molds and designs. Must admit I do like the cobalt rimmed stuff from Mexico. Nice richness, good hand feel. Found two for a 1$ ea. 12.95 on regular market.
0 -
YAY inadvertently found this. Bought it months ago for less than 5$. Not sure of price really, but know I snapped it up. Was conversing with a relative on Fb and made a post about my Mantra about glass. Told them I had a piece in mind for them. Within a 1/2 hour I found the name. How weird is that?
Round Platter in Vincennes by Cristal D'Arques-Durand. http://www.replacements.com/webquote/CRAVIN.htm
Not a high price on Ebay 40$ range. Unusual b/c it's highly leaded--sparkly. Really outstanding. Pic absolutely doesn't do it justice.
Shep, this is an example of acceptance. Can't find it, than in a moment it's--------------Snagged it.
0 -
Gentle hugs and healing thoughts for Mags, JunieB, Annie and Holeinone.
Susan ~ Hope you had a safe trip home. So sorry for your Mom and the loss of her pup.
Loverly ~ Hubby home today
Sas ~ How true; easiest way to find something is stop looking! So many pretties you found. And yes, the older docs don't care about the Genelex findings. My MO is older, but is also a researcher, so I was very surprised he wasn't interested. Very excited about what the Onc/Neuro guy will find. My VKROC1 (CYP2C9) is 1/1 Normal. Love how you were able to take charge of Greg's meds. Both of you were going through hell at that time; I am awed that you were able to decipher all that info and keep track of everything. I'm sure Greg was proud of your determination and comforted that you were taking such loving care of him.
I've found some resources online that explain and chart phenotypes - probably stuff you already know. Fascinating...
AIBioTech Patient Home page
http://www.aibiotech.com/patients
Pain Management Narrative Ion Torrent.pdf
http://www.aibiotech.com/sites/default/files/files...
Mayo Clinic Pharmacogenomic Associations Tables
http://www.mayomedicallaboratories.com/it-mmfiles/Pharmacogenomic_Associations_Tables.pdf
0 -
sas
As with any research, take away is of value to the person seeking knowledge; our DNA is unique to each of us and no two cancers are the same.
I will post what I can find that is published in the US; but as you may know many studies are performed outside the US with different results and interpretation. If reports are available, I will also post from other countries.
Please note my Vit D3 intake is monitored by two different doctors (allopath; naturopath) this is the only issue they both agree on. My levels are monitored every three months by blood tests. If I miss a dose or two a week, I don't sweat it. I do not spend time in the sun due to rads. I know my body and value blood tests for accuracy, I'm a numbers person, so this works for me. My dx, two different types of bc in the same tumor.
NOTE: take a 25-hydroxyvitamin D blood test to baseline and every 3 months thereafter to assess and adjust your dosage so your optimal blood levels will be where they should be year-round.
*****
Check back for updates on this post. . .
*****
http://www.ncbi.nlm.nih.gov/pubmed/27120467
See comment in PubMed Commons belowBreast Cancer Res Treat. 2016 Apr 27. [Epub ahead of print]
Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer.
Thakkar A1,2, Wang B1, Picon-Ruiz M1, Buchwald P3, Ince TA4,5.
Author information
- 1Sylvester Comprehensive Cancer Center, Department of Pathology, Braman Family Breast Cancer Institute and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
- 2Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami, Miami, FL, USA.
- 3Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA.
- 4Sylvester Comprehensive Cancer Center, Department of Pathology, Braman Family Breast Cancer Institute and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA. Tince@miami.edu.
- 5, Biomedical Research Building, Room 926, 1501 NW 10th Avenue, Miami, FL, 33136, USA. Tince@miami.edu.
Abstract
Anti-estrogen and anti-HER2 treatments have been among the first and most successful examples of targeted therapy for breast cancer (BC). However, the treatment of triple-negative BC (TNBC) that lack estrogen receptor expression or HER2 amplification remains a major challenge. We previously discovered that approximately two-thirds of TNBCs express vitamin D receptor (VDR) and/or androgen receptor (AR) and hypothesized that TNBCs co-expressing AR and VDR (HR2-av TNBC) could be treated by targeting both of these hormone receptors. To evaluate the feasibility of VDR/AR-targeted therapy in TNBC, we characterized 15 different BC lines and identified 2 HR2-av TNBC lines and examined the changes in their phenotype, viability, and proliferation after VDR and AR-targeted treatment. Treatment of BC cell lines with VDR or AR agonists inhibited cell viability in a receptor-dependent manner, and their combination appeared to inhibit cell viability additively. Moreover, cell viability was further decreased when AR/VDR agonist hormones were combined with chemotherapeutic drugs. The mechanisms of inhibition by AR/VDR agonist hormones included cell cycle arrest and apoptosis in TNBC cell lines. In addition, AR/VDR agonist hormones induced differentiation and inhibited cancer stem cells (CSCs) measured by reduction in tumorsphere formation efficiency, high aldehyde dehydrogenase activity, and CSC markers. Surprisingly, we found that AR antagonists inhibited proliferation of most BC cell lines in an AR-independent manner, raising questions regarding their mechanism of action. In summary, AR/VDR-targeted agonist hormone therapy can inhibit HR2-av TNBC through multiple mechanisms in a receptor-dependent manner and can be combined with chemotherapy.
*****http://www.ncbi.nlm.nih.gov/pubmed/24239860
Create FileSee comment in PubMed Commons belowJ Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:65-73. doi: 10.1016/j.jsbmb.2013.10.022. Epub 2013 Nov 14.Modeling vitamin D actions in triple negative/basal-like breast cancer.
Author information
- 1Cancer Research Center, University at Albany, USA; Department of Biomedical Sciences, University at Albany, USA.
- 2Cancer Research Center, University at Albany, USA; Department of Environmental Health Sciences, University at Albany, USA. Electronic address: jwelsh@albany.edu.
Abstract
Breast cancer is a heterogeneous disease with six molecularly defined subtypes, the most aggressive of which are triple negative breast cancers that lack expression of estrogen receptor (ER) and progesterone receptor (PR) and do not exhibit amplification of the growth factor receptor HER2. Triple negative breast cancers often exhibit basal-like gene signatures and are enriched for CD44+ cancer stem cells. In this report we have characterized the molecular actions of the VDR in a model of triple negative breast cancer. Estrogen independent, invasive mammary tumor cell lines established from wild-type (WT) and VDR knockout (VDRKO) mice were used to demonstrate that VDR is necessary for 1,25-dihydroxyvitamin D3 (1,25D) mediated anti-cancer actions in vitro and to identify novel targets of this receptor. Western blotting confirmed differential VDR expression and demonstrated the lack of ER, PR and Her2 in these cell lines. Re-introduction of human VDR (hVDR) into VDRKO cells restored the anti-proliferative actions of 1,25D. Genomic profiling demonstrated that 1,25D failed to alter gene expression in KO240 cells whereas major changes were observed in WT145 cells and in KO clones stably expressing hVDR (KO(hVDR) cells). With a 2-fold cutoff, 117 transcripts in WT145 cells and 197 transcripts in the KO(hVDR) clones were significantly altered by 1,25D. Thirty-five genes were found to be commonly regulated by 1,25D in all VDR-positive cell lines. Of these, we identified a cohort of four genes (Plau, Hbegf, Postn, Has2) that are known to drive breast cancer invasion and metastasis whose expression was markedly down regulated by 1,25D. These data support a model whereby 1,25D coordinately suppresses multiple proteins that are required for survival of triple-negative/basal-like breast cancer cells. Since studies have demonstrated a high prevalence of vitamin D deficiency in women with basal-like breast cancer, correction of vitamin D deficiency in these women represents a reasonable, but as yet untested, strategy to delay recurrence and extend survival. This article is part of a Special Issue entitled '16th Vitamin D Workshop'.
KEYWORDS:
Breast cancer; Invasion; Microarrays; Vitamin D
*****
From NIH site
Vitamin D
Cancer
Laboratory and animal evidence as well as epidemiologic data suggest that vitamin D status could affect cancer risk. Strong biological and mechanistic bases indicate that vitamin D plays a role in the prevention of colon, prostate, and breast cancers. Read more from link below.https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
0 -
I am joining ShepK with the hugs for HiHo, Mag, and JunieB.
JunieB, I thought about the effects of Ibrance on your blood counts. Hopefully, they go back to normal before surgery in June. Praying for no delays.
Annie, you sound good. Isn't it so nice not to have the hard plastic expander(s) poking you any longer? Hope you are healing well. I won't let my DH do the laundry. He is excellent in turning my white shirts to tie dye ones. He is good in washing dishes. I promoted him to the Chief Dishwasher years ago because he is thorough and fast.
Susan, hope you are resting well before the next round. More pics of Elena when you get a chance.
Ms. Smarty, yay for Nick!
Ms. Sas, you live up to your OCD. Ha! I like the glass wine. Gave my set away years ago as we hardly used them
ShepK, how is Marti doing?
Yup DH is home. He is upstairs going through piles of mails. He takes care of all the bills because I'm disorganized (or pretending) Yup. I'm spoiled. You got it right, Feline- he is a good man
. Well, he tries. Glad he is home.0 -
I forgot to say yesterday, HiO, I had the taxoterrible too, and although the red devil is worse in the short run, tax has long lasting effects, especially with things like eyes and noses. Eyes just start leaking. Nose drips, especially when I'm eating. But whatever works, right?
When I went to bed last night I noticed that the cyst seemed squishy on top, so I slathered antibiotic ointment on a telfa pad and stuck it on. Sure enough, this morning it was yucky. Cousin doctored it up for me and doc says let's see how it looks on Monday.
Sassy, I try to read all that stuff but my eyes cross. My brain is fried.
Still not really up much, gut is just achy. No d or c today, just a little loose. I probably have some of that infamous opioid induced constipation as well.
*Waving* Crash.0 -
Marti is still doing really well on her new meds. She has been very unladylike, rolling like a pony in the grass! And if not in her mouth, her toys are always nearby
Not bad for 12!
0 -
For Mags ~
0 -
Oh Mags, one problem at a time. Goodness!
ShepK, thanks for the picture of Marti. She is a goof ball like Mitzy. This is her playful position too.
She is waiting for her really late night walk. Ta ta for now.
0 -
Mitzy is such a happy girl
0 -
MammaR, you are out late! Another true night owl you are. Good to hear from you!
0 -
How is treatment going? Headaches gone or improved? How is your baby? DH? What's on your mind? Ok, that's enough questions for now :
0 -
That was supposed to be a smiley face
My phone ignores the last character when I forget to hit "space".0
