Switching from Letrozole to Tamoxifen
Hi All,
My sister was diagnosed with ILC stage 2 in October 2023. She had double mastectomy and she been on anastrozole and letrozole since then. She is post-menopausal. Recently side effects of AIs been hard. Her oncologist recommended switching to Tamoxifen. From what I have read Tamoxifen isn`t very effective for post-menopausal women with ILC. Does anyone have been in similar situation, or they have read any recent research on it that they can share. Appreciate your help
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Hi dear
My mom was diagnosed 13 years ago with ILC stage 3b she used anastrazole for 7 years ultimately diagnosed with osteoporosis, stopped anastrozole and now her cancer is back unfortunately, doc has started tamoxifen hope it will work for her.
LLots of prayers for ur sister hope some one will show up with uf answer.
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Thank you for sharing. Healing prayers for your mom as well. 🙏
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Some information here regarding ILC and tamoxifen
https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://lobularbreastcancer.org/wp-content/uploads/2025/04/ILC-Myths-vs-Facts.pdf&ved=2ahUKEwj1ve24_-KQAxXZUUEAHaNtA80QFnoECBgQAQ&usg=AOvVaw0NW4bfip8GhuEnapFQIU39
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Hi @sanazsabeti65, Over 8 years the disease free survival rate taking AIs is statistically 82 % for those with both IDC and ILC. Over 8 years the disease free survival rate taking tamoxifen is statistically 75% for those with IDC and 66% for those with ILC. Some people with ILC do as well on tamoxifen as those with IDC but there is not an easy way to distinguish them.
These statistics can help those with difficult SEs decide what to do. QOL is an important consideration. There are also factors like tumor size and grade that are not broken out in these percentages. Statistical numbers look at large populations and can't predict what will happen to an individual. All the best to you and your sister.
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thank you all for sharing
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