TRIPLE POSITIVE GROUP
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Still trying to figure out HOW to post a pic of my hair ..... nothing is working for me....
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fluffqueen01 triple negative and HER2+/hormone- are the more aggressive than triple positive. Did I post that backwards before? HEr2+/hormone- at least has Herceptin etc to treat but seems it is more like triple negative. Both seem to have a high recurrence rate in the first 2-3 years then really drop offs with a lower incidence of recurrence it the late future.
chicaroo44 If you are BRCA1+ your lifetime risk of breast cancer and ovarian cancer is higher. Talk to your doctor about the information below. I don't understand the 40% HER2+ but if that means you are positive it's not unusual to have a low or no ER/PR status.:
Cancer risks for women with HBOC
- Lifetime risk of breast cancer 50% to 85%
- Risk of breast cancer before age 50 30% to 50%
- Lifetime risk of ovarian cancer
- BRCA1 gene mutation 25% to 40%
- BRCA2 gene mutation 15% to 27%
Netty not sure what that means.
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Netty, are you sure he didn't say estrogen?
Lago, I think you posted correctly. My thought process was that if you are triple neg, you don't have the her2 component. So, if you are double neg and then have the her 2 (I know there is herceptin then), would it be considered more agressive than triple neg? It seems like the her2 component surrounding the other negative cells would be even worse than if it was her2 surrounding estrogen and progesterone positive cells. Of course, I guess it is all relevant in the long run.
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It's androgen. It's a new receptor they found. Soon we will see her 2 pos er pos. Ar pos. Ar is for androgen. Google it.
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Fluff queen read this
http://www.biomedcentral.com/content/pdf/1471-2407-8-149.pdf0 -
Interesting.
Re: androgen receptors -
Androgens are another class of sex hormones, and epidemiologic studies have supported their role in breast biology and carcinogenesis [2-4]. In fact, the androgen receptor (AR) is expressed in the vast majority of breast cancers, with some studies reporting expression of AR in up to 90% of primary tumors and 75% of metastatic lesions [5,6], although more contemporary studies suggest that the frequency of AR expression varies depending on the subtype of breast cancer (for example, ERα-positive (luminal) versus triple-negative and basal breast cancers), and other clinical and pathologic parameters [7-9].
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More info
http://www.coloradocancerblogs.org/decoding-cancer-androgen-–-a-new-hormone-target-in-triple-negative-breast-cancers/0 -
Lee A. Yes not many women have heard of this.
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U women are all amazing-really boy am I glad we don't get tested on any of these boards.
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Re: androgen - I suppose if our tumors weren't tested for it at the time of excision we'll never know if they were androgen positive or not; however, according to the article c/p below - 77% of them might be androgen positive. And this is even important for women who have or had triple negative tumors because up to 20% of those tumors might be AR+.
Fewer pink frying pans and more research, please!
Link:
Evidence increasing that breast cancer is driven by androgen
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Fluff I know at one time hormone negative, HER2+ had a worse prognosis than triple negative but since herceptin the prognosis has improved by about 50%. I do believe it is considered similar to triple negative just like we triple positives get similar treatments for agressive hormone positive
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Very interesting articles on androgen. Hopefully the research will lead to more tools in the pink toolbox!
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I have read about the androgen factor in the past few months. It seems to be a relatively recently new direction for DX and hopefully targetting treatments.
Androgen and the idea that Her2 plays a role in many different cancers and even in so called her 2 neg cancer are looking very significant right now.
Sure do hope so:)0 -
Again I cannot understand what the doc meant last month when she said your tumor has this good thing called androgen. She is one of the top in triple negative research. Ironically my radiation oncologist tryed to tell me something like this also about I fell into a new subtype that was discussed in December in Texas. As you know I had recurrence lastcyr same breast as 12 yrs back. But after I was done she told me about the androgen and threw numbers at me like 95 percent won't come back to chest 97 percent won't come back systemically. Little puzzling. I questioned her and she told me she never throws words out without having proof.
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My doc was speaking alot and throwing out all these numbers too me so I was kinda frozen but when I go back I will ask her to explain exactly what she meant about androgen being good thing.
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Sorry I lost the link "
Androgens
Some 75 percent of all breast cancers and 10 to 20 percent of triple negative cancers are positive for the androgen receptor. Several research studies have looked at the influence of androgen receptors on TNBC, which means new treatments plus a broader and deeper understanding of the disease. TNBC cancers that are also positive for androgen receptors are molecularly similar to prostate cancer and could potentially be treated similarly.
AR-positive tumors responded well to bicalutamine and to 17-DMAG, a drug that has been recently in clinical trials, according to research presented by Jennifer Pietenpol, PhD, director of the Vanderbilt-Ingram Cancer Center.
A phase 1 clinical trial at the University of Colorado has been studying the effectiveness of enzalutamide, a drug used to treat prostate cancer, on triple-negative. A phase 2 trial is planned at Colorado, Memorial Sloan-Kettering Cancer Center and the Karmanos Cancer Institute.
A Heterogeneous Disease
It is increasingly clear that TNBC is not one disease, but a family of diseases, some of which are highly aggressive, and some that are not aggressive at all. We're getting increasingly closer to knowing which ones are which. "0 -
I did some quick research on this and it looks really promising! But I how will they know if we gals were (I love saying that--were) androgen receptor positive?
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FINALLY figured out the photo thing !!!! Spikes !
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ChickaD
Spikes.... Yikes! Very cute. Mine has been cut several times and is just a little longer and chemo curly. You just may decide to keep it short. Not quite sure but I think I may .
As has been oft repeated... Go out and 'fight like a girl'!0 -
Thank you Miss Ashla... I am ready !
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Liking the spikes, ChickaD!
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Re: Androgen - I've always had acne problems but my skin went haywire right after I had my last period back in 2003. I need to pull out my July 2012 blood test (just prior to finding out the lump was malignant). I'm curious to see what my testosterone levels were.
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Thanks Miss Lee.... I kinda just noticed that my spikes look like my chick avatar's head -- LOL
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ChickaD I was going to say that and I love spikes--I do that with my hair sometimes, now for as long as u can get some hair chalk and fluff some color in some spikes--Love it.
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YAY -- favorite color is purple -- I think I will have to borrow my daughter's hair chalk soon !!!
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ChickaD,
Love the hair...0 -
Thanks Miss Sherry !!!!!!
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ChickaD... sweeeet hair! And now you know how great you look in spikes, maybe you'll feel better knowing it won't be all that long before you have that cute do again. (Okay, I did the same thing, cut my hair short... liked it... and it helped me look forward to a cute short do, instead of worrying about how long it would be before it was long again.) I'm thinking of getting a couple hair extensions on one side... to make it really look like I planned this hair do! (I'd have to draw a picture to make that 'look' make sense)
Go, ChickaD... routing for you!0 -
pbrain ask your doc. Lots of cnacer research hospitals run these kind of test. You can also contact pathology they will pull tumor and run the AR test on it.
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Thanks for the encouragement Miss FeelingTheMagic!
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Netty, interesting! It will be interesting to see where it leads. Not sure there is enough there to require me to see if they could retest. It sounds like they think it has an effect, but not sure where to go with it. So much is going to change in ten years, I think! My BS said they are standing at the top of this mountain, surrounded by all this research and new information, but not sure yet what to do with it all.
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