How are people with liver mets doing?
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Hi All -
Had my liver biopsy today. It went well and they even sedated me with conscious sedation. Last time they did not. I was relieved.
Home resting now with significant pain with movement. I am confident this will improve quickly. Supposed to start Halaven Monday while we wait for pathology report to come back.
Thank you for all your caring and support.
Gumdoctor
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Husband, Bev, Candy...
So the ALT went from 300 to 260 and the AST went from 230 to 130. but the bilirubin went up to 2.0.... She said it could be progression...but she feels its more likely one of the supplements and she is leaning towards the Mebedazole or the MSM. She wants me off everything including the Xeloda until Monday at which time we will draw blood again..if the numbers are even better Tuesday I can start the Xeloda. I scan Tuesday and Wednesday so we will have a better feel for what it going on then. My liver has been hurting a little tonight I think food has to do with it...but who knows.
Also she said whenever the liver is inflamed its called Hepatitis that doesn't mean that I contracted Hep B or C....she also ordered test today for B & C and is ordering A on Monday...(she forgot to order A today).
Nicole
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That sound encouraging Nicole. Its moving in the right direction, so how can that be progression of cancer?
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Husband11,
Good point about Nicole. Your observation makes sense.
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Gumdoctor, I am relieved to see you had a liver bx. It will be good to know if you have hormonal changes to your cancer. I might have missed this, but am assuming Foundation 1 or similar is being done from this new bx?
You have been through a rough 6 months..but I sense great strength in you.
Keep talking to us.
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Nicolerod..good to see you posting. I agree with the others, if ALT and AST are decreasing, sounds like something reactive and not progression.
Is it possible to stay off supplements and just use Xeloda until your liver is happy? Then reintroduce slowly? I guess I am ignorant to your supplements.
Sounds like you have a great MO and ND who is supportive with what you are trying to do and helping you to quickly resolve these recent lab concerns.
S
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Gumdoctor- Thinking of you. I will be waiting to read your post on liver bx results and how things go Monday with treatment.
Nicole- I don't know anything about supplements as I don't use any. But I agree with Sandi--Xeloda only till liver is ok and reintroduce supplements slowly if you want to use them still?
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Grannax2- 28 year survivor of this horrendous disease .....you rock! We do have some similarities for sure! I was diagnosed with mets after 10 years @ 45- bones, lungs & liver right out of the gate. Feel a-bit cheated but who doesn’t with MBC? I’m also ERPR+,HR2-. You are an inspiration. Wondering when you were diagnosed mets? Were you always ESR1 resistance? They do not have any mutation testing here and when I have progression, I will seek that kind of information on my tumors.
Praying for Nicole glad to read numbers are decreasing and Gumdoctor for more information soon that brings peac🙏🙏🙏
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anewbreath We are in a similar boat. My first time I had no visible mets but I was treated with FAC x6 and mastectomy with TRAM Flap reconstruction, Second DX was eight years later (2000),
In my right breast and my cervical spine. So, that's the first time mets appeared. Back then, MD A put me in a trial. Surgery, C3 corpectomy with strut and graft then Taxotere x6. Next DX was 2009, right breast again. Mastectomy and radiation and Abraxane. 2016 DX mets to liver, lung and mediastinal lymph node. There you have it.
From 2001 on I was on several different anti estrogens and numerous A Is. I had trouble taking them for different reasons. I don't know for sure when I became AI resistant. Nobody checked for that until 2017. Genomic testing is kind of a newish thing but I believe.it is going to be thing that helps to personalize our TX. I hope you will be able to have it someday. So, are you ten years out from mets?
Yesterday I went to the sweetest Valentine's breakfast at my Granddughter's school. They do this every year for widows and seniors. They set everything up to look like we were on a cruise ship. Ill
Post a pic.
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Such a great pic, Grannax. You both look lovely!!
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Hi Ladies...thank you all so much for your concern and questions...I feel like you are all with me.
Ok. Husband11...progression because she said "we can never just say "its definitely not that"..we have to always consider it"..but she did say "I REALLY think its a supplement or the Xeloda or both of those"...
She wants everything included the xeloda stopped until I get blood work Monday (results Tuesday) if the numbers dropped again..I can resume Xeloda... I will then add in 1 supplement...probably the Low Dose Naltrexone...because I KNOW either that or the MSM were getting rid of my inflammation now that I stopped them I am all inflamed...bad.
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Grannax2- no 10 years after stage 2, I was diagnosed out of the blue with bone and visceral mets So hanging in for 2.5 years. The picture with your granddaughter is precious and I love how active you are with your grandchildren ❤️ I also had the diep reconstruction procedure using my groin and was wondering how that would work with they90 that possibly uses the same groin? You mentioned that the y90 may be referred differently...when I research doctors near me what procedures also include y90?
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anewbreath. They didn't have any trouble accessing my artery to get to the liver. The first time they used the artery in the groin area. Now, most IR s use the wrist artery. That's what they did for me this time. It was so much easier for me. They do a mapping first, then one lobe and then the other lobe. It's three separate procedures. Your Diep may be different than my Tram. Mine used the rectus abdominal muscle.
Yes, my grandchildren only live about an hour away. I feel fortunate to be able to drive to see them. I live in a Dallas suburb ,so even though it takes almost an hour, it's still in the Metroplex. 💞
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While I didn't expect biopsy path report today, it is here...
Abnormal left liver MRI appearance is where they biopsied...diffuse metastatic carcinoma. Because both right and left sides are heavily involved, no-go on Y90.
This takes away a huge opportunity for non-chemo liver treatment.
Starting Halaven today. Waiting for all labs to come back before we start.
I feel like I am on the fast track to my casket now.
Gumdoctor
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Gumdoctor,
I don't know what to say here. Has the IR completely ruled out y90? You don't do both sides at once.
Hoping that Halavan can at least slow things down somewhat. Thinking of you.
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Yes - Y90 ruled out.
Gumdoctor
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lots of love gumdoctor. I’m sorry for the news.
We will hold out hope Hale an will work in those Mets go you.
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Gumdoctor, I have involvement in both lobes. I was put on systemic chemo AdrIamycin and Cytoxan. Afterwards I went on Ibrance/ Letrozole.
My MO had to be careful with dosing due to liver involvement.
Would that be an option? Do you have the energy to ask for consult?
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Ibrance and fulvestrant failed at 18 mos, last July. Halaven is now my 4 chemo - xeloda, abraxane, IMMU-132 and now Halaven.
Gumdoctor
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Gumdoctor..is AC not an option? Are you too weakened?
It is harsh, but it was effective against my widespread liver mets. My MO had to be very careful with dosing so liver would not shut down
Seems like you need to stop this beast fast and hard.
Keep posting..I just don't think you are at casket time yet. You will find the right combo. Please keep up your nutrition and sit outside with your kitties. Breathe.
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GumDoctor. Why is y90 ruled out? I have mets across both tumors and on my first signs of progression, I will get Y90 treatments. They don't do both lobes at the same time. See a specialist who uses Y90 for breast cancer - many do not and are uncomfortable with it. Maybe worth a second opinion? My first opinion was someone who did not use it to treat breast cancer and he gave me thumbs down, but second doc was specialist in Charlotte NC. He gave me full rundown on everything about procedure and a thumbs up.
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Gumdoctor- I cannot give any advise that has not already been given. Just wanted to let you know I care. Hugging you now. Damn cancer, damn it to Hell.
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HopeandGratitude -
Apparently several reasons. I have to re-group. For several reasons, I am probably not realistically able to pursue another consult in a different location.
Lots to think about.
Gumdoctor
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Anyone hear from nbnotes? She was on Gemzar and was just thinking of her.
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I searched and NbNotes' last post was late Jan 2020 in a different thread. Her post sounded upbeat.
Gumdoctor
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Gumdoctor, I’m thinking about you and hope that Halaven destroys those liver mets and give’s you time to regroup. I received 6 months of Carbo/taxol and it did help with my defused liver mets in both lobes...scary time, but it definitely can happen. I’m praying you can kick the mets back and possibly revisit CDK’s...hugs!
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gum doctor- I have heard good things about haloven. Hoping it works. I had a bland embolization to part of my liver with diffuse mets while I had y-90 to the 2 largest tumors. The bland embolization is supposed to stop the blood supply to a section of the liver and kill all the tumors. The point is to reduce the tumor burden in the liver.May be that Could be an option.
Wishing you the best.
Dee
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Hi. I have never heard of bland embolization. I found a good description off the BCO ablation, Y90 thread. The article says you can have it with your chemo. It apparently is followed by ablation. Interesting.
https://prd-medweb-cdn.s3.amazonaws.com/documents/...
AlabamaDee, thank you for mentioning this. I wonder if the procedure was originally for liver cancer, but found to be effective to Breast cancer liver mets, too.
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Sandibeach 57 & Gumdoctor --- Still here! Thanks for asking/checking. Just been a couple of crazy weeks; so, I've read some but not posted. I am still on Gemzar. It kept doing a number on my platelets so we have kept the lowered dose and now are doing every other week. With that schedule 2 weeks ago before my infusion, my ANC & wbc were actually firmly in the normal range - yay! Platelets were only 94, but still high enough to do the chemo. My tumor markers had been slowly rising, but they decreased 2 weeks ago as well - whew! I'm supposed to have my next infusion along with my 6 month Zometa this afternoon. I've got some petechiae due to low platelets along with some fatigue in the off week, but in general things are going well.
Gumdoctor -- sorry to hear your news & that you wouldn't be able to do the local treatment you hoped for. Hoping halaven will be the magic bullet to get rid of all those liver mets!
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