Switching from Ibrance to Verzenio - Tips?
Daughter/caregiver here to a mom (70yo) with MBC. I'd love to know if anyone has experience switching from Ibrance directly to Verzenio.
Context: My mom has been on Ibrance for 14 months, with an excellent response. She quickly had to reduce her dose to 75mg due to immediate neutropenia, but was able to get a handle on significant bone, liver and lung mets (there's nothing left in her lungs or liver) with this dose. She went from being very sick to getting back to all her normal activities like singing, exercise, hanging out with friends. However, her TMs had been going up the last 6 months or so, and a recent PET scan finally showed some progression in her hip, and a couple other tiny spots in her spine. Her doctor is recommending a switch from Ibrance + Anastrozole to Verzenio + Fulvesant because: 1) Less neutropenia issues with Verzenio, so her MO thinks she might be able to tolerate a higher does which will control the disease better, and since she so well did well on this class of drugs her doctor would prefer her to stick with it as long as possible; 2) Fulvesant is a stronger estrogen-blocker.
- Anyone have experience switching from Ibrance immediately to Verzenio? How was your experience?
- I'm currently combing through the Verzenio thread for info on what to expect in terms of SEs, and how to manage those, but if anyone has any top tips, I'd love to hear them! I'm particularly concerned about the diarrhea, as we are going on a bucket list trip to New Zealand in 5 weeks. My mom is starting Verzenio immediately, so we'll have a couple of weeks to see how the drug treats her, but I want to do what we can now to prepare since I know the first weeks/months can be the worst in terms of SEs. (Important to note that her doctor is fully supportive of this trip!)
Thank you in advance for any and all insights!