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After mastectomy problem.

Hi

My mother has triple negative breast cancer,stage 1,tumor grade 2, no lympnode are affected . After the doctor said it was cancer, the operation was done. The type of operation was mastectomy. It has been 44 days since the operation but the seroma is still not closing. Now what can be done in this situation?

What could be the problem if the seroma does not close?
Our cancer specialist has said to give him 8 cycles of chemotherapy now. But I'm worried that the seroma is not closing but can chemotherapy inside it cause any problems?
Looking for expert opinion.