Verzenio + fulvestrant increased OS in ER+/HER2+ MBC

olma61

I guess this could eventually mean a new first line for estrogen positive HER2+ patients. This was just a Phase 2 trial so I suppose there has to be a Phase 3 before it would become common in clinical use. Looks like they didn’t include Perjeta (pertuzumab) in this protocol, either.

CONCLUSION:

In this phase II trial, abemaciclib + trastuzumab +/- fulvestrant numerically improved median OS in women with HR+, HER2+ ABC compared to SOC chemotherapy + trastuzumab.

LINK: Practice Update - Metastatic Breast Cancer Newsletter

https://www.practiceupdate.com/c/158894/67/13/?elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_metastaticbreastcancer&elsca4=metastaticbreastcancer&elsca5=newsletter&rid=NDcyNTI4MzY5MTA0S0&lid=20849614