Ki-67- ONCOTYPE? What was everyone’s experience?
I’m just sort of curious. For those who had a ki-67 number before your oncotyoe, what were your numbers? I’m wondering how often a high ki-67 results in a high oncotype, and vice versa. What’s your experience?
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my Ki-67 was 60 and my oncotype was 32 or 34 I forget. high and high basically
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ki-67 can values can be different depending on methods used to score it, so it can be unreliable on its own. Also, I believe the level of estrogen in your system due to your cycle can effect the score. It should correspond with your oncotype score. My biopsy showed ki-67 of 40%, and was done during peak estrogen days during my cycle. My final pathology showed ki-67 of 15%, was done during lowest estrogen days of my cycle, and my oncotype was 14.
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thats very interesting waves.
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@waves2stars yes very interesting! M ki-67 showed 40% both times. I was really just curious because some things I read say big correlation between the two and others say no correlation or little correlation.
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Ki-67 is only one of the markers used to calculate your oncotype. My ki-67 was 40% and my oncotype was 24 so no recommendation for chemo at my age. I did have a surprise positive lymph node and LVI but the only change to my treatment plan was the addition of axillary radiation. In spite of treatment generalities everyone’s situation is unique so it is impossible to predict what is going to happen until all the results are in and your MO considers your case in conjunction with any other health issues you may have and your preferences.
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@maggie15 thanks for the info! I also had the LVI and lymph node involvement. I’m seeing a radiology oncologist now in addition to the medical oncologist. I’ll be anxious to see if they also end up deciding to radiate. I did the mastectomy in hopes of not having to do that but I’ll do whatever I have to I guess! I know radiation is nothing but I am working a full time job so didn’t love the idea of radiation so many days per week.
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@ebfitzy , If you are working hospitals are good about scheduling you for radiation late or early. I was teaching online and had to drive 100 miles each way. I stayed overnight in a hospital owned hostel (basic but cheap) and made two round trips a week. They ran the linac machines from 6 am to 9 pm and a shorter schedule on Saturday. I didn’t get totally wiped out until it was over and fortunately school was out then. You’ll manage to do whatever you have to. FMLA is available if you end up having treatment which impacts your ability to work. I hope things go smoothly for you.
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My Ki-67 was .08 and 3%. It was checked at different labs. My oncotype was 7. I was stage 1A, no node involvements. Had lumpectomy and 5 accelerated partial breasts radiation treatments.
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My KI-67 was 50 but my ONCOTYPE was 18, no chemo needed, Stage 1B, Grade 2, 4 cm, right Invasive Lobular Cancer, 3 lymph nodes positive but not beyond the sentinel nodes, had a double mastectomy, 15 radiation treatments. Recently started Anastrozole and my oncologists is suggesting Verzenio because of the hi KI-67. Weird the KI-67 score and Oncotype scores are so different, one low risk, one high risk. Has anyone else experienced this ?
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@nanaofgirls thats VERY interesting!
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@nanaofgirls thanks for sharing this information. Verzenio is typically recommended if you have the high Ki-67 , and positive lymph nodes. Take a look at this article
So your treatment team thinks this would be beneficial to help reduce risk of recurrence. Given the positive lymph nodes, this is the reason that they are likely recommending Verzenio. You may want to talk with your treatment team in more detail about this, and maybe consider a second opinion if that would give you some help making your decisions.
We're here for you,
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My Ki67 was 43% and Oncotyope 10. No chemo needed. On Tamoxifen for 5 years. My cancer: IDC Stage 1 grade 2. No lymph involvement.
My very good oncologist told me that in the last 10 years - Oncotype TRUMPS your Ki number. I hope this helps.
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I didn’t get any Oncotype score as my cancer was in my nodes so they knew I had to do chemo.
My ki-67 score was 75%.Scared me witless. But my oncologist explained it’s not a standardised thing and many hospitals (I’m in the UK) don’t even report on it.
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My ki-67 was 8 and I was told I would not need chemo. Surgeon said all the things they use to determine chemo were negative in my case (no lymph node involvement, small tumor size, ki-67 very low, hormone receptor positive, her2 negative, and almost didn’t send the tissue sample to get the oncotype testing done because there was so little tissue!). But, the medical oncologist decided to send my tissue sample anyway, and thank god he did. My oncotype score was 33. The entire team managing my care was shocked! None of them expected it to be so high. So, here I am going through chemo. It. Sucks. But, I’d rather take care of it now than risk a recurrence!
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@Love4All - this was my case as well. I only pushed for the Oncotype because my doctor said it would also give numbers for reoccurrence for being on hormone treatment. Lo and behold 33 and I've just completed 4 rounds of chemo.
Here's my question - when it makes it predictions for Reoccurence and survival, does the Oncotype ASSUME that the patient is also having radiation? It doesn't state that on the test results itself, when I try and find the answer to that online I can't. My Oncologist says it does.
The other thing I can't find an answer for is an explanation for the range for Onctotype—they essentially have two camps—25 and under and 26 and over—with a range of up to 100. The range of 26-100 is such a big jump. I came back at a 33% on stage 1 no lymph node 17m grade 3. indeed 33 is closer to 26 than it is to 100 right? I would love to know what the percentage of increase is once you go over 26 and how that percentage increases for their range to 100. But I can't find anything online.
Help?
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Hi @jprice2019, The Oncotype recurrence score predicts the effectiveness of chemo and a 9 year recurrence score when endocrine therapy is used. It does not take radiation into account since while those who have a lumpectomy usually have RT, those who have mastectomies often do not. Whether an individual has RT and its type is not reported to Exact Sciences since RT generally follows chemo. The extent of RT and the field radiated differs among patients.
As far as the difference in percentage increases goes your MO might be able to shed some light. There is a provider portal that has more information about each patient's results than what is available on the patient printout. If there is a graph provided it might yield some info. My MO is a researcher and was able to answer some of my questions using the information on his portal and his familiarity with current clinical trials but I never asked exactly how score increases relate to recurrence increases. The statistical analysis used for the Oncotype is complex, different from what most people study in beginning stats courses. The relationship between values is not linear so someone with an Oncotype of 60 does not have twice the risk of recurrence of someone with an Oncotype of 30. The details of the calculations are probably proprietary so that other companies can't use them. The usefulness of the Oncotype was demonstrated in clinical trials and while the general statistical methods employed are often mentioned the details are company secrets.
I hope your treatment goes well.
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