Her2 low / negative with Brca1 mutation
good day, I was recently diagnose with breast cancer. I have appt to see a breast surgeon soon. I have just got my pathology report and I used Chatgpt to get a better understanding of all of it.
though am still confused at one point
I am ER- PgR- and Her2 low / negative
I was also genetic tested a few years back with the Brca1 mutation.
Does the Her2 low / negative mean I am triple negative?
Also this ki-67 has me at 83% and intensity of 3+
Comments
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Hi @aortiz268, and welcome to Breastcancer.org. We're so very sorry for the reasons that bring you here, but we're really glad you've found us. You're sure to find our incredible community a wonderful source of advice, information, encouragement, and support — we're all here for you!
First, here is some information on how to understand the pieces of your pathology report. Also, some good info on HER2 status and what HER2-low status can mean in terms of treatment. As well, what a genetic mutation like BRCA1 can mean for treatment.
We hope this helps get you started and that others will be by soon to weigh in with their experiences. Let us know how else we can help!
—The Mods
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@aortiz268 I'm so sorry to hear of your recent diagnosis. We all are here for your support, this site has a fabulous group of people.
I am TNBC, BRACA negative ,when all receptors are negative you are TNBC. However they now pay attention to your Her2 numbers also for other treatment options. For instance I tested a plus 1 for Her2 low so that now opens up the door to more treatments. It has been a game changer in the Triple Negative world.
Sending strength and positive vibes your way.
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Thank you all for the support. I see that everyone here is nothing but supportive which is always great to have in time of need. and reading all the experiences that are share will give me an idea of what’s to come and what to expect.
my pathology was as follows
- Estrogen Receptor (ER): Negative (0% tumor stained, Allred Score: 0)
- Progesterone Receptor (PgR): Negative (0% tumor stained, Allred Score: 0)
- HER2 Status: Negative/Low (Score: 1+)
- HER2 IHC Score: 2+ (Equivocal)
- HER2 FISH Result: Negative (Not Amplified)
- Ki-67 Expression: High (83% tumor stained, indicating high proliferative activity)
- Genetic Mutation: BRCA1 exon 24 deletion present
Tumor Characteristics (Right Breast - 2:00 Position):
- Invasive Grade 3 Ductal Carcinoma (No Special Type)
- Nottingham Score: 8/9 (High Grade)
- Tubule Formation: 3 (Poor differentiation)
- Nuclear Features: 3 (Highly abnormal-looking cells)
- Mitosis Rate: 2 (Moderate proliferation rate)
- Tumor Size: 1.5 cm
- No lymphovascular invasion detected.
Left Breast (2:30 Position) Findings:
- Florid sclerosing adenosis with columnar cell changes (Benign Condition)
- Immunochemistry confirms myoepithelial cell presence (Supports benign nature).
I’ve opted to have a Double Mastectomy as well as a future hysterectomy due to family history.
i am wondering what to expect for chemo being that i am triple negative and Brca1 positive.
i have read about PARP inhibitors but i don’t know if that will be an option to me.
also i don’t know if anyone has done this before but the ChatGPT ai. has be great with summarizing and showing treatment plans if you feed it your pathology and other info it comes back with a ton of useful information as well as helps you create questions for your first doctor visits. this form and that AI has been extremely useful these past few days.
Can anyone help suggest questions for the Oncologist. That I might want to ask?
Should I push to have my PD-L1 checked at this stage?
Being triple negative with Brca1 is there a set amount of chemo that might be given?
Does the chemo port stay in once your fully done with chemo?
Sorry for all the questions but thank you guys for caring and sharing so much.
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I am a long time bc patient, but not a doctor or medical professional. You may not be considered triple negative. I am also HER2 negative/low and have not been treated as triple negative nor have others I’ve seen in a similar situation. There have been clinical trials to see if treating HER2 low as HER2 positive, in terms of tx, is effective but I don’t know what the outcome was. This would be one of the questions for your oncologist rather than relying on our opinions. You may not be considered triple negative at all.
Ports require maintenance which is done while you are receiving tx. After tx, it will be removed (unless you fancy having it flushed/maintained every month😊). There is a lot to learn about bc as it turns out to be more complex than most realize. These boards are very supportive but few of us are medical professionals (and not your doctor) so it is best to get information about your particular situation from your doc. Take care0
