Anyone on TRUQAP?
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Hi. Is anyone out there on drug trial for Scorpion's PI3Kα inhibitor program STX-478?
If so, how is it going?Sad to say, had progression on Truqap after 12 months and current looking for “the next” treatment plan.
Drug trial is one option I’m being offered.
thanksKat
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Fellow Truqap people. I regret to report that after three months on the drug, my liver mets multiplied. Of course, I'm disappointed because I had an easy five-year run on Ibrance and my SFs on Truqap were equally mild. My next course is Enhertu. I've already checked out the Enheru thread. Best wishes to all.
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Hi all, just popping in here to provide our site's information on this topic:
We hope this helps!
—The Mods
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I am still on Truqap. The last scan a week ago showed mixed results and maybe a tiny progression. The scan before that was really good. I have been on half a dose since last August. We are upping the Truqap dose To 320 two times per day to see how I respond now and to try and get more time out of this drug. My D is under control on the half dose.
It seems to still be working but not quite as well - thus the upping the dose.
I have been on it consistently since August so we are approaching the one year mark. 🤞🏻1 -
Hi, I am a 19 year old female with metastatic stage 4 ovary cancer that has relapsed twice. I recently had surgery because they found another cancer tumor growing in my lung this time. My doctor has been recommending me to start on truqap for about a year now. I am seriously starting to consider it now since my 4 rounds of hardcore chemo did not work at all. I came here because I needed to hear from other ladies how their experience went. I am terrified of starting chemo again, especially losing my hair at this age is hard. Did you guys lose your hair on this pill? If you have any words of advice for starting this pill or encouragement, it would be very helpful. I am so sorry you ladies are going through this. We'll all get through it ❤️ god bless!
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Hello @ilovecats12. Thank you for posting your story in the BCO Community forum.
We’re so sorry to hear what you’re going through. Please know you’ve come to the right place. This community is filled with people who truly understand and are here to support you.
If you haven’t had a chance to explore the site yet, I’d like to share a link with you about Truqap. Hopefully, this resource can offer some helpful insight while you wait for other community members to respond and share their experiences.
The BCO Mods
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@ilovecats12 I was only able to stay on Truqap for 3 months due to progression, but I was ready to stay on forever. I had mild side effects and there was no hair loss. My co-pay situation was a nightmare, however. I know some other people on this thread had issues as well. I was going to be out-of-pocket for thousands of dollars a year even with a co-pay card and a grant and great insurance. Not completely sure why Truqap was different from, say, Ibrance, in terms of dollars. Even so, it would have been worth it for me. I hope you do well with whatever treatment option you choose.
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@ilovecats12 Welcome to this thread. I am very sorry that at your age you have to go through such an ordeal, but I sense from your message that you are a very courageous person.
I was on Truqap for 6 months and I didn't lose my hair, on the contrary, it started to grow back slowly after losing it under chemo.
I tolerated Truqap well (better than any other targeted therapy). The major problem was diarrhea which was controlled with Immodium and a low fiber diet.
I hope this treatment works well for you. Best thoughts.0 -
Welcome @ilovecats12 I am so sorry you are dealing with this at such a young age. I agree you are very brave and this forum is great place for support and information. I was on Truqap for 6 1/2 months and it greatly decreased my tumor burden. The side effects were very tolerable. I was fatigued at times and had to watch my blood sugar at times from being low. My hair grew very healthy and thick while on it. Praying it works well for you. Blessings.
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will be starting this drug soon at recommended dose…thank you for all your comments…helps so much
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two weeks on truqap and the diarrhea got me and rash is on eyelids and sides of face…been in the hospital two days trying to figure it out…hopefully Onc will lower the dose so I can keep trying…I haven’t seen any post since joining the group
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@airlinegal I was given Ceterizine for rash prevention (it worked) and Ondonsatran (sp?) for nausea (don't think I needed it). I used Immodium for mild D. So sorry you had to go the hospital!
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thank you for the advice…are you on full dosage
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@airlinegal I was on full dosage, but Truqap didn't work for me. After three months, I had liver progression. I'm on Enhertu now.
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Hi, I've joined you from Australia as Truqap is new here (just been introduced on our national health scheme) and even though I belong to the Australian bcna metastatic online group there is no previous info out there, so am interested to know from others experiences how they are doing on this medication. I have read a little on this site about the effects people are experiencing, so that's been helpful, thank you.
I have had metastatic breast cancer for 7 years ( first diagnosed with my first breast cancer in 1996 at age 46 yrs) and have several lines of treatments, some good some not so, but this drug sounds promising, if we can manage side effects. When I really think about it, I'm amazed that I'm still here after nearly 30 years.
I'm only in my third week of tablets and at the end of 2nd week (4th day) had vomiting and diarrhoea so my Onc has reduced my dose to 600mg per day. This week has been much better although did get a mouth ulcer and thrush, much improved by Nilstat mouth drops. The fulvestrant injections don't bother me and haven't noticed any side effects from this yet. Oh yes have a pink spotty rash on my torso but am taking some antihistamine tabs to offset any itchiness.
Cheers to all.
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I'll be starting Flaslodex + Capivasertib (Truqap) to target my mbc's AKT mutation. Anyone have experience with this combo? And if so, how long have you been on it, or how long were you on it? AI says: "Median progression-free survival (PFS) = 7.2 months. Many patients remained controlled well beyond that median; about 1 in 4 had responses lasting ≥ 12 months."
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@bk143w I was on Truqap and Fulvestrant last year, which allowed me to have a lovely summer without too many side effects. I was able to go on short hikes, tend to the vegetable garden, and live a normal life. After eight months, I developed severe eczema despite taking allergy medication, and I had to stop the treatment. On this thread, you'll find many tips and tricks that helped me a lot... and Imodium often saved me from unpleasant situations during bouts of diarrhea.
I hope you can take this medication for a long time. Sincerely,0 -
@love178newport Seven years...it's wonderful to read this, it's encouraging...I'm in my second year and I've changed therapies often. It's a difficult learning curve for me, having never had to take medication before my cancer diagnosis in 2016.
I hope your discomfort with Truqap disappears quickly with the reduced dose. In addition to the antihistamine, I was using cortisone ointment to reduce the rash.
Best of luck to you with the rest of your treatment.0 -
@soldanella Thank you for your reply, I have also been on many treatments over the 7 years so am glad I can encourage you by my journey. We are fortunate that there are new and better treatments coming along. I hope you are keeping well and still able to enjoy your garden and hiking.
All the best.
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