Join Us

We are 216,350 members in 84 forums discussing 160,204 topics.

Help with Abbreviations

Topic: PALB2 mutation

Forum: Positive Genetic Test Results —

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, and mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM)

Posted on: Oct 13, 2011 07:55PM

NannaBaby wrote:

Anyone else get tested for PALB2 gene mutation?

NannyBaby, dx May 2010 at age 28. Neo-Chemo AC+Taxotere, surgery uMx, 25 Tomo rads, more chemo Cisplatin+Vinorelbine. Dx 5/28/2010, IDC, 6cm+, Stage IIIB, Grade 3, ER-/PR-, HER2- Chemotherapy 6/3/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery 12/13/2010 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Radiation Therapy 2/19/2011 3DCRT: Breast, Lymph nodes Chemotherapy 3/31/2011 Carboplatin (Paraplatin), Navelbine (vinorelbine) Surgery 7/12/2012 Reconstruction (left): DIEP flap
Log in to post a reply

Page 5 of 5 (122 results)

Posts 121 - 122 (122 total)

Log in to post a reply

May 20, 2020 07:38PM hyphencollins wrote:

Hello Ddolina, I'm sorry to hear that you are dealing with this during this time. Are you able to get a telehealth appt. to get your questions answered? My own experience is it's most stressful when things are uncertain and even difficult things are easier when you have information! Having said that, have you been getting regular mammograms due to your age and family history? If so, that seems very reassuring. Nothing the breast cancer geneticist will recommend or do is urgent so waiting a bit wont impact that (although it's the unknown that's stressful). The Palb2 gene doesnt mean you will get breast cancer either-- I will share that my Aunt who must have been positive for the gene (cousin was positive for it) died at an old age and never had breast cancer even though, like you, her mother died of it at age 40. Best wishes, stay healthy!

Multifocal IDC with EIC. Oncotype 23. Palb2 mutant. Dx 5/2014, DCIS, Grade 3 Dx 5/2014, IDC, Left, 1cm, Stage IIA, Grade 1, 1/11 nodes, ER+/PR+, HER2- Surgery 7/31/2014 Lymph node removal: Left; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 10/2/2014 AC + T (Taxol) Radiation Therapy 1/26/2015 Breast, Lymph nodes Hormonal Therapy 3/9/2015 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy Arimidex (anastrozole)
Log in to post a reply

May 26, 2020 12:07PM micdpowers wrote:

Checking in to this forum for the first time. Diagnosed with breast cancer on 2/14/20 and genetic test revealed PALB2 mutation. I'm 44. Not sure what side it came from yet, but there is no history of breast cancer on my father's side (2 aunts) or my mother's (2 aunts plus my mother). I'll have to find out which side it came from as I have 1/2 siblings on my father's side who should know.

@Ddolina, one phrase I've learned since my diagnosis is "the mind makes mischief". When we are in periods of uncertainty (waiting for test results, etc.) our minds can imagine all sorts of things - usually the worst things. PALB2 mutation, like @hyphencollins before me wrote, does not mean you'll ever get it. I'm the only woman in my family so far to show up with it. It just means extra screening for you (breast MRI I believe) at this point, which - when you can get it done - will hopefully give you extra peace of mind as it detects more than a mammogram.

Diagnosed at 45. ​Mother of three: 9, 11, 13. PALB2 Mutant. Dx 2/14/2020, IDC, Right, 5cm, Grade 3, ER-/PR-, HER2+ (IHC) Targeted Therapy 2/24/2020 Perjeta (pertuzumab) Chemotherapy 2/24/2020 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy Herceptin (trastuzumab)

Page 5 of 5 (122 results)