Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.
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Breastcancer.org strives to bring you updates on the latest breast cancer research through its Research News program. Medical experts at Breastcancer.org provide easy-to-understand summaries of what the research means for YOU.
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Jan 18, 2018 02:45PM
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Combo of Tykerb, Herceptin, and Aromatase Inhibitor Seems Best for Metastatic, HER2-Positive, Hormone-Receptor-Positive Disease
January 12, 2018
The combination of Tykerb, Herceptin, and an aromatase inhibitor seems better than just Herceptin and an aromatase inhibitor or just Tykerb and an aromatase inhibitor for treating metastatic HER2-positive, hormone-receptor-positive breast cancer in postmenopausal women. Read more...
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Lynparza Approved to Treat Metastatic HER2-Negative Breast Cancer in Women With BRCA Mutations
January 12, 2018
On Jan. 12, 2018, the FDA approved Lynparza to treat metastatic HER2-negative breast cancer in women with a BRCA1 or BRCA2 mutation. Read more...
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Study Estimates Risk of Rare Cancer From Breast Implants
January 16, 2018
A Dutch study estimates that for every 7,000 women who get breast implants, one woman will develop anaplastic large-cell lymphoma in the breast by age 75. Read more...
seagan
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Jan 18, 2018 03:38PM
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seagan
Have we heard anything about whether MBCers with other, “BRCA-like" (DNA repair gene) mutations - such as CHEK2, which I have - will be eligible for Lynparza, if not now, soon?
I know of at least one clinical trial looking at another PARP inhibitor in non-BRCA, inherited mutations (a talazoparib trial at Stanford: https://clinicaltrials.gov/ct2/show/NCT02401347 - see cohort arm 2). But that's only at one location and requires measurable disease.
Would love to hear PARP inhibitors are becoming more accessible to those of us with non-BRCA mutations, either through trials or exceptions to narrowly approved drugs like this one.
CHEK2 mutation
Dx
2/17/2009, IDC, 1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR+, HER2-
Dx
5/20/2016, IDC, Stage IV, metastasized to bone/other, ER+/PR+, HER2-
Targeted Therapy
6/1/2016 Ibrance (palbociclib)
Hormonal Therapy
6/1/2016 Faslodex (fulvestrant)
Chemotherapy
1/26/2017 Xeloda (capecitabine)
Radiation Therapy
4/24/2017 External: Bone
Radiation Therapy
7/25/2017 External: Bone
Hormonal Therapy
10/20/2017 Femara (letrozole)
Targeted Therapy
10/20/2017 Afinitor (everolimus)
Radiation Therapy
11/9/2017 External: Bone
Chemotherapy
1/9/2018 Abraxane (albumin-bound or nab-paclitaxel)
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Jan 24, 2018 10:16AM
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Hi Seagan, and thanks for posting. This thread is reserved for posting only Research News articles provided by Breastcancer.org, in an effort to get the breaking news to the Community, without diverting the conversation to other discussions about specific stories. If you'd like to further discuss an article here, we'd suggest going to the specific thread on this article: community.breastcancer.org/for... or starting your own thread here in the Research News forum.
Thank you for understanding!
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Study Estimates Risks of Radiation Treatment for Breast Cancer in Women With Scleroderma
January 19, 2018
Research suggests that some women diagnosed with scleroderma and breast cancer treated with radiation had long-term skin tightening or thickening in the treatment area, but no disease flare-up. Read more...
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Two New Genetic Mutations Linked to Higher Risk of Breast Cancer
January 24, 2018
A study has found that mutations in the MSH6 and PMS2 genes are linked to higher-than-average breast cancer risk. Read more...
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January 30, 2018
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February 1, 2018
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February 2, 2018
SB3, a biosimilar to Herceptin, seems as effective and as safe as Herceptin. Read more...
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February 20, 2018
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March 7, 2018
The FDA has authorized a direct-to-consumer test to identify BRCA mutations, but it's important to know that the test only looks for three mutations that are extremely rare in the general population. Read more...
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Most Newly Diagnosed Women Don't Receive Genetic Counseling, Even Though They Should Have It
March 16, 2018
Fewer than 50% of women newly diagnosed with breast cancer who should receive advice from a licensed genetic counselor actually get counseling. In addition, only about half of the women who should have genetic testing actually have that testing. Read more...
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New Guidelines Say Accelerated Whole-Breast Irradiation Should Be Used to Treat Most Breast Cancers
March 18, 2018
The updated guidelines say that most women diagnosed with breast cancer should be treated with accelerated whole-breast irradiation as the standard of care. Read more...
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Researchers Identify 110 Genes Associated With Breast Cancer
March 21, 2018
A research team has associated 110 genes with a higher risk of breast cancer using a new genetic analysis technique. Read more...
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Apr 5, 2018 12:13PM
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Scalp Cooling Is Safe, Effective for Reducing Hair Loss Due to Chemotherapy, Study Finds
March 30, 2018
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Black Women Added to High-Risk Group for Breast Cancer
April 27, 2018
Because black women have higher breast cancer mortality rates than white women, the American College of Radiology and the Society of Breast Imaging have recommended that black women be added to groups considered at high risk for breast cancer. Read more...
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Women With Low Muscle Mass Have Worse Survival
May 3, 2018
Women diagnosed with stage II or III breast cancer who have low muscle mass have worse survival rates than women with higher muscle mass. Read more...
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May 10, 2018
A study suggests that screening mammograms every 2 years or more often are linked to breast cancers that are diagnosed at an earlier stage, which lowers the need for more aggressive treatment. Read more...
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Family History of Breast Cancer Dramatically Increases Risk of Cancer in Other Breast
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A family history of breast cancer substantially increases the risk of contralateral disease in younger women. Read more...
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May 11, 2018
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May 16, 2018
My Changed Body, a web-based structured writing exercise, can help ease distress related to body image and increase self-compassion among women treated for breast cancer. Read more...
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Most Women Have Multigene Genetic Testing, but Not Until After Surgery
May 17, 2018
A study has found that most women now have multigene testing after a breast cancer diagnosis, but this genetic testing is happening later in the treatment plan than testing for only BRCA1 or BRCA2 mutations. Read more...
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Genetic Testing Criteria May Miss Women With Mutations Linked to Breast Cancer
May 30, 2018
A study suggests that women who don't meet breast cancer genetic testing guidelines are just as likely to have mutations linked to breast cancer as women who meet the guidelines. This means that a large number of genetic mutations linked to breast cancer are being missed. Read more...
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Early Results Suggest 6 Months of Herceptin as Effective as Treatment for 1 Year
June 2, 2018
First results from the PERSEPHONE trial suggest that giving Herceptin for 6 months after surgery and chemotherapy offers the same decrease in recurrence risk as giving it for 1 year. Read more...
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June 4, 2018
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"It is the first time that a patient with late-stage breast cancer has been successfully treated by a form of immunotherapy that uses the patient's own immune cells to find and destroy cancer cells that have formed in the body."
https://www.theguardian.com/science/2018/jun/04/do...
Dx
1/5/2015, DCIS, Stage 0, Grade 1, ER+/PR+, HER2-
Dx
2/10/2015, IDC, Right, <1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- (FISH)
Surgery
2/11/2015 Lumpectomy: Right; Lymph node removal: Right, Sentinel
Radiation Therapy
4/13/2015 Whole-breast: Breast
Hormonal Therapy
6/11/2015 Femara (letrozole)
Hormonal Therapy