Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.
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Breastcancer.org strives to bring you updates on the latest breast cancer research through its Research News program. Medical experts at Breastcancer.org provide easy-to-understand summaries of what the research means for YOU.
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Jan 18, 2018 12:45PM
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Combo of Tykerb, Herceptin, and Aromatase Inhibitor Seems Best for Metastatic, HER2-Positive, Hormone-Receptor-Positive Disease
January 12, 2018
The combination of Tykerb, Herceptin, and an aromatase inhibitor seems better than just Herceptin and an aromatase inhibitor or just Tykerb and an aromatase inhibitor for treating metastatic HER2-positive, hormone-receptor-positive breast cancer in postmenopausal women. Read more...
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Lynparza Approved to Treat Metastatic HER2-Negative Breast Cancer in Women With BRCA Mutations
January 12, 2018
On Jan. 12, 2018, the FDA approved Lynparza to treat metastatic HER2-negative breast cancer in women with a BRCA1 or BRCA2 mutation. Read more...
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January 16, 2018
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seagan
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Jan 18, 2018 01:38PM
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seagan
Have we heard anything about whether MBCers with other, “BRCA-like" (DNA repair gene) mutations - such as CHEK2, which I have - will be eligible for Lynparza, if not now, soon?
I know of at least one clinical trial looking at another PARP inhibitor in non-BRCA, inherited mutations (a talazoparib trial at Stanford: https://clinicaltrials.gov/ct2/show/NCT02401347 - see cohort arm 2). But that's only at one location and requires measurable disease.
Would love to hear PARP inhibitors are becoming more accessible to those of us with non-BRCA mutations, either through trials or exceptions to narrowly approved drugs like this one.
CHEK2 mutation
Dx
2/17/2009, IDC, 1cm, Stage I, Grade 2, 0/3 nodes, ER+/PR+, HER2-
Dx
5/20/2016, IDC, Stage IV, metastasized to bone/other, ER+/PR+, HER2-
Targeted Therapy
6/1/2016 Ibrance (palbociclib)
Hormonal Therapy
6/1/2016 Faslodex (fulvestrant)
Chemotherapy
1/26/2017 Xeloda (capecitabine)
Radiation Therapy
4/24/2017 External: Bone
Radiation Therapy
7/25/2017 External: Bone
Hormonal Therapy
10/20/2017 Femara (letrozole)
Targeted Therapy
10/20/2017 Afinitor (everolimus)
Radiation Therapy
11/9/2017 External: Bone
Chemotherapy
1/9/2018 Abraxane (albumin-bound or nab-paclitaxel)
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Jan 24, 2018 08:16AM
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Hi Seagan, and thanks for posting. This thread is reserved for posting only Research News articles provided by Breastcancer.org, in an effort to get the breaking news to the Community, without diverting the conversation to other discussions about specific stories. If you'd like to further discuss an article here, we'd suggest going to the specific thread on this article: community.breastcancer.org/for... or starting your own thread here in the Research News forum.
Thank you for understanding!
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January 19, 2018
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January 24, 2018
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January 30, 2018
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New Guidelines Say Accelerated Whole-Breast Irradiation Should Be Used to Treat Most Breast Cancers
March 18, 2018
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March 21, 2018
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Apr 5, 2018 10:13AM
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April 27, 2018
Because black women have higher breast cancer mortality rates than white women, the American College of Radiology and the Society of Breast Imaging have recommended that black women be added to groups considered at high risk for breast cancer. Read more...
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May 3, 2018
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May 10, 2018
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May 17, 2018
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June 2, 2018
First results from the PERSEPHONE trial suggest that giving Herceptin for 6 months after surgery and chemotherapy offers the same decrease in recurrence risk as giving it for 1 year. Read more...
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"It is the first time that a patient with late-stage breast cancer has been successfully treated by a form of immunotherapy that uses the patient's own immune cells to find and destroy cancer cells that have formed in the body."
https://www.theguardian.com/science/2018/jun/04/do...
Dx
1/5/2015, DCIS, Stage 0, Grade 1, ER+/PR+, HER2-
Dx
2/10/2015, IDC, Right, <1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- (FISH)
Surgery
2/11/2015 Lumpectomy: Right; Lymph node removal: Right, Sentinel
Radiation Therapy
4/13/2015 Whole-breast: Breast
Hormonal Therapy
6/11/2015 Femara (letrozole)
Hormonal Therapy