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Topic: Afinitor/Aromasin 2013

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

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Posted on: Feb 8, 2013 12:28PM

Posted on: Feb 8, 2013 12:28PM

sueco wrote:

I am waiting for my pills to arrive and fearful of starting a chemo after almost seven years of anti-hormones.  I immediately started looking for info on this site, and the Afinitor topic was started in Jan. 8, 2012 with 35 pages of comments to go through.  Do you think it is possible to start a new topic now that this med combination has been just recently been approved by the FDA? 

Sue Dx 4/15/2006, Stage IV, mets, ER+ Hormonal Therapy 5/15/2006 Arimidex (anastrozole) Hormonal Therapy 8/18/2008 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/20/2010 Faslodex (fulvestrant) Targeted Therapy 2/14/2013 Afinitor (everolimus) Radiation Therapy 1/15/2014 3DCRT: Bone Chemotherapy 2/17/2014 Xeloda (capecitabine) Chemotherapy 8/20/2015 Abraxane (albumin-bound or nab-paclitaxel)
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May 16, 2022 11:12PM perky2020 wrote:

Intolight - yes, yay that labs are positive! Info understand Verzenio is stronger than Ibrance. Hopefully your body will adjust and the fatigue is not so noticable.

You probably have gotten a lot of advice for!the Faslodex shots. But I found a good massage therapist is invaluable!! Hope you get a good, long run! They both can be great treatments!

NKB - yes, would love to add a hormone blocker to the Verzenio. Onc advised against Tamoxfin as the SE's would likely be a lot. Hopefully one of these SERDs or other will be an option!

For trials, I did not find anything as well. The Destiny06 looked possible but I understand Xeloda can be easier to tolerate over Enhertu so I would probably just go with xeloda first. Are you Her2 low? Guessing itnwill get FDA approval at some point soon-ish?

Looks like our therapies have a similar path. I did have a small progression at 3 yrs with ibrance but we radiated those spots and I got another year!

Afinitor has been relatively easy. A number of bouts with mouth sores and mild head sores. More fatigue then I remember on Ibrance but other than that okay.

Dx 2/6/2015, IDC, Left, 2cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR-, HER2- Surgery 3/17/2015 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 5/27/2015 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 10/1/2015 Arimidex (anastrozole) Hormonal Therapy 11/1/2016 Aromasin (exemestane) Dx 12/27/2016, IDC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 1/2/2017 Faslodex (fulvestrant) Targeted Therapy 1/12/2017 Ibrance (palbociclib) Radiation Therapy 1/15/2017 External Local Metastases 1/15/2017 Radiation therapy: Bone Radiation Therapy 4/13/2020 Other part Radiation Therapy 5/16/2021 Other part Targeted Therapy 10/1/2021 Afinitor (everolimus) Hormonal Therapy 10/4/2021 Aromasin (exemestane) Hormonal Therapy 4/1/2022 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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May 17, 2022 12:13AM nkb wrote:

Perky- I am Her 2 low (2+). I discussed Destiny with my UCSF MO about 18 months ago - she thought they might take me- but, you needed two biopsies for Destiny and she wasn’t sure they would take bone biopsies. Enhertu has a lot more SEs than Xeloda and you lose your hair, its an infusion. I want to save it til I am much sicker-(when it gets approved) - will see how much more time I can eke out of Xeloda.

Dx 12/2011, ILC, Both breasts, 6cm+, Stage IIIC, Grade 2, 34/40 nodes, ER+/PR+, HER2- Surgery 2/4/2012 Lymph node removal; Lymph node removal (Left): Underarm/Axillary; Lymph node removal (Right): Underarm/Axillary; Mastectomy; Mastectomy (Left); Mastectomy (Right) Chemotherapy 2/28/2012 AC + T (Taxol) Radiation Therapy 9/11/2012 Hormonal Therapy 10/21/2012 Arimidex (anastrozole) Dx 5/2017, ILC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 6/1/2017 Faslodex (fulvestrant) Targeted Therapy 6/1/2017 Ibrance (palbociclib) Targeted Therapy 3/13/2019 Afinitor (everolimus) Hormonal Therapy 3/13/2019 Aromasin (exemestane) Chemotherapy 3/10/2020 Xeloda (capecitabine) Targeted Therapy 9/13/2022 Enhertu (fam-trastuzumab deruxtecan-nxki)
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May 17, 2022 05:07AM joynerl wrote:

nkb, I got almost 3 years out of Xeloda with only HNF as real SE. A good run.

As you may recall, I have the ESR1 mutation, too, but my MSK onc recommended my staying on Afinitor and Aromasin. Started in January. So far, so good....

--Lynn Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Surgery 1/1/1991 Lymph node removal (Left); Mastectomy (Left): Simple; Reconstruction (Left): Nipple reconstruction, Tissue Expander Surgery 1/2/1991 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left): Nipple reconstruction, Saline implant Chemotherapy 1/15/1991 CMF Chemotherapy 1/22/1991 CMF Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Hormonal Therapy 2/1/2017 Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 2/13/2017 Faslodex (fulvestrant) Targeted Therapy 2/23/2017 Ibrance (palbociclib) Hormonal Therapy 3/5/2017 Faslodex (fulvestrant) Targeted Therapy 3/5/2017 Ibrance (palbociclib) Radiation Therapy 1/9/2019 External Local Metastases 1/9/2019 Radiation therapy: Bone Chemotherapy 1/17/2019 Xeloda (capecitabine) Chemotherapy 2/22/2019 Other Radiation Therapy 10/27/2020 External: Lymph nodes Targeted Therapy 1/1/2022 Afinitor (everolimus) Hormonal Therapy 1/1/2022 Aromasin (exemestane) Targeted Therapy 1/1/2022 Afinitor (everolimus) Hormonal Therapy 1/1/2022 Aromasin (exemestane)
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May 17, 2022 09:50AM perky2020 wrote:

Lynn - fingers crossed! It has been pretty tolerable!

Dx 2/6/2015, IDC, Left, 2cm, Stage IIA, Grade 2, 0/3 nodes, ER+/PR-, HER2- Surgery 3/17/2015 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 5/27/2015 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 10/1/2015 Arimidex (anastrozole) Hormonal Therapy 11/1/2016 Aromasin (exemestane) Dx 12/27/2016, IDC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 1/2/2017 Faslodex (fulvestrant) Targeted Therapy 1/12/2017 Ibrance (palbociclib) Radiation Therapy 1/15/2017 External Local Metastases 1/15/2017 Radiation therapy: Bone Radiation Therapy 4/13/2020 Other part Radiation Therapy 5/16/2021 Other part Targeted Therapy 10/1/2021 Afinitor (everolimus) Hormonal Therapy 10/4/2021 Aromasin (exemestane) Hormonal Therapy 4/1/2022 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)

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