Topic: Lynparza/Olaparib Anyone?

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Feb 1, 2018 01:18AM - edited Feb 1, 2018 01:19AM by geekness

Posted on: Feb 1, 2018 01:18AM - edited Feb 1, 2018 01:19AM by geekness

geekness wrote:

I'm looking to share side effects or just any updates on Lynparza / Olaparib. I just started targeted therapy on Jan 12th. Aside from a little heartburn at first (helped with OTC pill), I've now started some daily Immodium, which the pharmacy sent WITH the Lynparza. Lol. I've started to just feel plain odd and very emotional. I can usually keep it together. I'm wondering if anyone else is yet on this medication. I'm Brca1 Stage 4 (Triple Negative) with mets to lungs and sacrum/soft tissue. I was doing gemzar/Carbo until December, which was keeping three small modules in lungs stable, but not helping anything in sacrum. So we switched it up and both insurance and pharm are helping me with copays on the meds, which I know I am very lucky to have had happen. It seems I can't find a big group yet that's taking this drug to compare how they might be feeling and I'd love to try and connect with a few people. I think even that might help me get right in my brain for a bit.

Chemotherapy 9/2/2015 AC + T (Taxotere) Dx 8/2017, IDC, Left, Stage IV, metastasized to bone/lungs, Grade 3, 0/15 nodes, ER-/PR-, HER2-
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Feb 8, 2022 10:11PM star2017 wrote:

I started Lynparza and then a week later started radiation. I've been okay, but mine was only 13 treatments for a bone met. I know the chest treatments can be more involved.

CURRENT: Stage IV since 2020, bone mets to rt hip, sacrum, femur, all treated with radiation. Taking Lynparza daily. Dx 9/2017, DCIS/IDC, Right, 6cm+, Stage IIIA, Grade 3, 4/8 nodes, ER+/PR+, HER2- Surgery 10/17/2017 Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Chemotherapy 11/29/2017 AC + T (Taxol) Surgery 4/18/2018 Prophylactic mastectomy; Prophylactic mastectomy (Left); Reconstruction (Left): Tissue Expander; Reconstruction (Right): Silicone implant Radiation Therapy 5/21/2018 Whole breast: Breast, Lymph nodes Surgery 10/24/2018 Reconstruction (Left): Silicone implant Hormonal Therapy 6/19/2019 Arimidex (anastrozole) Dx 5/2021, IDC, Right, 6cm+, Stage IV, metastasized to bone, ER+/PR+, HER2- Targeted Therapy Verzenio Radiation Therapy External Hormonal Therapy Faslodex (fulvestrant) Local Metastases Radiation therapy: Bone
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Mar 27, 2022 04:32AM sondraf wrote:

Resurrecting this thread so it is a bit more to the top of the forums!

Hollyli - this drug is not in standard use for breast in the UK at this time so my onc had to do some arranging for a few weeks and ultimately it looks like it came through the compassionate use channel. I wasn't in crisis so a few weeks to wrap up the rads and get the drugs was ok.The timing of L4 deciding to get its grow on, being caught early on my scan cycle, and fitting in with rads scheduling, worked out surprisingly well.

Almost two weeks in and so far its been a good ride. Man I hope this is working because I feel better on this than I did on Ibrance for sure. Only had to take one anti-nausea pill so far, and that was a few hours after having my covid booster and consuming too much pizza at lunch, so not surprised. There are a few moments here and there in the day when i get a "tinge" - sort of like the pre-hot flash moment of dread, but I took star2017s advice and focus on other things until it goes.

I do get fatigued earlier in the evenings now but my sleep is a MESS. I went from like 5-6 hours light broken sleep to trying a low-dose antidepressant and sleeping 8-10 hours, which was great until I wanted to sleep them in the day and was up all night. I backed off those and now its 8 hours at night with vivid dreams, a few nightmares, and a sleep paralysis episode the other night. PT cleared me for stationary cycling which does help, but I have peeling/healing underboob skin from rads so need to be a bit careful on the sweat situation.

The two pills a day is a bummer, though. I kept my 7pm pills scheduling but obviously had to add in 7am! I always worry I will fall back asleep and miss the pill window, but the cats help keep me honest.

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/29/2019 Femara (letrozole) Targeted Therapy 11/29/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 Lynparza (olaparib)
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Mar 27, 2022 08:56AM candy-678 wrote:

Thanks Sondra for bumping this Thread.

I am still on Lynparza. Almost 7 months now. Dose reduction in month 3 I think. I still have episodes of nausea/lack of appetite, but they are way better than at first (hence the dose reduction). The fatigue is worse than with Ibrance, in my opinion. But, 2 scans later I am still "stable", no shrinkage, but no growth. So Lynparza continues.

Since the site overhaul my profile does not reflect the Ibrance discontinue and the start of Lynparza. I have tried to fix it, but cannot. I emailed the Mods. Hope I can get my profile fixed to reflect my current treatment.

April 2021 first progression and flip ER-/PR+ now. Current treatment as of Sept 2021 is Lynparza, Lupron (been on since Nov 2017), and Xgeva (been on since Nov 2017). Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Hormonal Therapy 11/1/2017 Femara (letrozole) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Lynparza (olaparib) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)
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Mar 27, 2022 10:05AM star2017 wrote:

HI Candy, I kept thinking I was doing something wrong when updating my profile, but I think it must be some bug, as you say. I'm so glad to hear things are stable!

My recent PET-CT showed no new mets, femur and sacrum met are inactive, and hip met has decreased uptake. There's a small fracture there that probably is also affecting it. I'm a little over 2 months on Lynparza. Hoping for continued good news.

The fatigue is definitely worse on Lynparza than on Verzenio, but the nausea is now rare for me and at least there's no GI upset as with Verzenio.

CURRENT: Stage IV since 2020, bone mets to rt hip, sacrum, femur, all treated with radiation. Taking Lynparza daily. Dx 9/2017, DCIS/IDC, Right, 6cm+, Stage IIIA, Grade 3, 4/8 nodes, ER+/PR+, HER2- Surgery 10/17/2017 Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Chemotherapy 11/29/2017 AC + T (Taxol) Surgery 4/18/2018 Prophylactic mastectomy; Prophylactic mastectomy (Left); Reconstruction (Left): Tissue Expander; Reconstruction (Right): Silicone implant Radiation Therapy 5/21/2018 Whole breast: Breast, Lymph nodes Surgery 10/24/2018 Reconstruction (Left): Silicone implant Hormonal Therapy 6/19/2019 Arimidex (anastrozole) Dx 5/2021, IDC, Right, 6cm+, Stage IV, metastasized to bone, ER+/PR+, HER2- Targeted Therapy Verzenio Radiation Therapy External Hormonal Therapy Faslodex (fulvestrant) Local Metastases Radiation therapy: Bone
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Apr 1, 2022 02:27PM - edited Apr 1, 2022 02:28PM by sondraf

Im such a plank, honestly. I was taking my evening dose and you know how it comes in these giant boxes? I keep my cancer-specific drugs in a discreet little box that OH or I grab when the phone alarm goes off. So I put strips of drugs in there, or the whole box if it will fit.Tonight I was emptying one of the boxes and noticed it said 2 tablets twice a day. Ive been taking one in the morning and one in the evening!!! I rectified that with this evenings dose, and its only been two weeks, but honestly!

Too many drugs at the moment - the letrozole, the mirtrazapine to help me sleep, the anti-nausea meds in case, the lansoprazole, the painkillers - most of it is when needed, and I dont need most of them, but being handed three at the same time at the start of a new drug well, I guess I just got confused.

Probably should have called the pharmacy hotline that is written in size 7 font on a piece of paper somewhere, but its Friday night and it wont reopen before Monday anyway.

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/29/2019 Femara (letrozole) Targeted Therapy 11/29/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 Lynparza (olaparib)
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Apr 1, 2022 10:55PM star2017 wrote:

Might want to ask about the leteozole with Lynparza. Is it needed?

CURRENT: Stage IV since 2020, bone mets to rt hip, sacrum, femur, all treated with radiation. Taking Lynparza daily. Dx 9/2017, DCIS/IDC, Right, 6cm+, Stage IIIA, Grade 3, 4/8 nodes, ER+/PR+, HER2- Surgery 10/17/2017 Mastectomy; Mastectomy (Right); Reconstruction (Right): Tissue Expander Chemotherapy 11/29/2017 AC + T (Taxol) Surgery 4/18/2018 Prophylactic mastectomy; Prophylactic mastectomy (Left); Reconstruction (Left): Tissue Expander; Reconstruction (Right): Silicone implant Radiation Therapy 5/21/2018 Whole breast: Breast, Lymph nodes Surgery 10/24/2018 Reconstruction (Left): Silicone implant Hormonal Therapy 6/19/2019 Arimidex (anastrozole) Dx 5/2021, IDC, Right, 6cm+, Stage IV, metastasized to bone, ER+/PR+, HER2- Targeted Therapy Verzenio Radiation Therapy External Hormonal Therapy Faslodex (fulvestrant) Local Metastases Radiation therapy: Bone
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Apr 3, 2022 04:00AM sondraf wrote:

I did ask before we started and onc chose to keep me on it as I was 100% ER/PR at the start so it seemed prudent to stay on it. She said she would pull me if I had intolerable side effects from the letrozole.

I clipped all the L into two pill strips so I just have to grab a strip. So far no increase in side effects thankfully!

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/29/2019 Femara (letrozole) Targeted Therapy 11/29/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 Lynparza (olaparib)
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Apr 19, 2022 05:49PM hollyli1202 wrote:

Sondra - oh dear! I am glad you're taking the four pills daily now. I wish I was still on Lynparza. I have been chatting with my oncologist asking if the other parp inhibitors work in the same way as lynparza. I'd like to try a new parp. There have been really no studies on it. After lynparza (for nearly two years), I went to carbo/gem for 4 months, then to taxotere for 5 months, and Trodelvy (3 months). Trodelvy isn't working now, so I am on to something else. I had the best run on Lynparza and am craving those days when all it was was just pills.


Star and Candy - glad olaparib is doing the trick! I hope it stays that way for many years!!

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Apr 21, 2022 03:18AM sondraf wrote:

i have had terrible, unrelenting indigestion since Monday - was doing just fine and its like a bomb went off in my gastro tract. Ive called in four times about it - I dont think they quite get that this isnt just "oh I felt off for two hours after breakfast" its climbing the walls level of irritation and pain around the clock. I haven't eaten anything substantial since Sunday and the Gaviscon i was advised to take while the PPI starts to kick in is just disgusting. Threw up last night and actually felt a bit better.

Ive been advised to take a break from the olaparib to get my stomach to calm down, so I missed last nights dose. We are supposed to be going to Italy on Monday for 4 days and I dont know, thinking of cancelling because right now leaving the house sounds insurmountable,never mind getting on a plane and going to another country :( I just want a vacation!

"The closer we come to the negative, to death, the more we blossom" - Montgomery Clift Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Hormonal Therapy 11/29/2019 Femara (letrozole) Targeted Therapy 11/29/2019 Ibrance (palbociclib) Surgery 11/28/2021 Lymph node removal (Right): Underarm/Axillary; Mastectomy (Right) Targeted Therapy 3/1/2022 Lynparza (olaparib)
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Apr 21, 2022 08:49AM candy-678 wrote:

Sondra- Oh my!!!! I have had GERD/indigestion for a long time---way before Lynparza. I use famotidine 40mg a day. Primary doc said I could use it twice a day if needed. I have not had an increase in the indigestion since starting Lynparza. For me the Lynparza causes nausea, no vomiting. But a feeling of nausea that comes in waves and even the sight of food makes me feel sick. Some days I feel fine, then out of the blue it will hit. I will feel fine, make dinner, eat, and then feel sick right after eating.

I am sorry you are struggling right now.

I am not a "vacationer". Never have been. But I know I would not enjoy it now with the fatigue and the nausea that comes on suddenly. I don't even want to make a dinner date with anyone because what if I feel sick and have to cancel. Or get to the restaurant, take a bite of food, and feel sick.

These cancer drugs are hard for QOL.

I hope you get relief and can restart the Lynparza and can tolerate it better. What dose are you on? Maybe a dose reduction. I was on the 600mg a day for the first 2 months and then lowered to 500mg a day. It did help the nausea---- was way worse with the 600mg. I still suffer, but not as much as before.

April 2021 first progression and flip ER-/PR+ now. Current treatment as of Sept 2021 is Lynparza, Lupron (been on since Nov 2017), and Xgeva (been on since Nov 2017). Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Hormonal Therapy 11/1/2017 Femara (letrozole) Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Dx 4/2021, ER-/PR+, HER2- Targeted Therapy 9/1/2021 Lynparza (olaparib) Chemotherapy AC Surgery Lymph node removal; Mastectomy; Mastectomy (Left)

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