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All TopicsForum: HER2+ (Positive) Breast Cancer → Topic: ATEMPT Clinical Trial - Roll Call

Topic: ATEMPT Clinical Trial - Roll Call

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Nov 21, 2014 11:43AM - edited Feb 7, 2017 10:43AM by MaggieCat

MaggieCat wrote:

The ATEMPT clinical trial has been going on for several years.

Are you participating?

The recruiting period is over. The planned participant level of 500 has been met.

Dx 10/16/2014, IDC, 1cm, Stage IA, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Dx 10/16/2014, DCIS, <1cm, Stage 0, Grade 3, 0/6 nodes, ER-/PR-, HER2+ Surgery 10/30/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Radiation Therapy 3/18/2015 Whole-breast Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Jun 14, 2017 06:00PM - edited Jun 16, 2017 06:54PM by TinyDancer5

Isabel, I am on Tamoxifen and Lupron. I have noticed that when I sit for a while, my hip joints getstiff, and I too hobble around a bit until it goes away. Sometimes when I stand up, I feel like I have to wait a minute and then start walking. If I kneel down, forget it. It takes longer for the stiffness to go away.

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Jun 15, 2017 10:17AM wabals wrote:

IsabelArcher

My US was normsal Except for some fat in my liver which is common esp in a 73yo.

Funny my lipid profile is awesome! Trig only 46.

Have been on arimidex for 17 mos. and I too have joint aches like you. I have always been very active so I hate that.

What are you on now

Dx 6/2015, IDC, Left, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ (FISH) Hormonal Therapy Radiation Therapy Surgery Lumpectomy: Left Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Jun 15, 2017 10:44AM TTfan wrote:

hi Isabel and all! I tried two different AIs for a total of a little over a year. Some of the joint pain and depression lifted within a week or two of stopping. I felt 95% better within a month or so. Happily those memories are a bit blurred now. I too thought I must have developed arthritis, I was too limited to exercise without serious pain. But the joint symptoms resolved completely and have not come back on Tamoxifen which I've been on for about 10 months now. The hot flashes are sweatier and a bit more intense on Tamoxifen, but Gabapentin helps with that. My energy levels are improved though not always what I would like. Some days I'm just tired without reason. Others I feel great - could be Tamoxifen, could just be age.

And on a brighter note, I recently put my new Scuba skills to the test with a week diving in Bonaire (near Aruba). I was thrilled that my gym work is helping and I can now stand up from the bench without helpand walk across the boat deck in full 40+ pound gear! Yay quad strength!

Wishing you all freedom from side effects and much happiness!

Dx 9/21/2014, IDC, <1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR+, HER2+ Surgery 10/9/2014 Lumpectomy: Left; Lymph node removal: Left, Sentinel Targeted Therapy 12/2/2014 Herceptin (trastuzumab) Chemotherapy 12/2/2014 Taxol (paclitaxel) Radiation Therapy 3/23/2015 Whole-breast: Breast Hormonal Therapy 4/27/2015 Arimidex (anastrozole) Hormonal Therapy 3/1/2016 Aromasin (exemestane) Hormonal Therapy 8/7/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jun 16, 2017 08:12AM IsabelArcher wrote:

Thanks to Tiny Dancer, Wabals, and TTFan for your replies. It's so helpful to hear other women's experiences. Given your similar experiences, I'm going to assume my current joint pain issues are indeed the anastrozole and NOT arthritis, and I hope very much they will just go away now that I've stopped the drug. My friend who had stage 2 ER+ BC had terrible joint pain from her AI (either anastrozole or the other one), but a 2-week break stopped the worst of it, so when she went back on, she felt some improvement. I can only encourage ladies coping with this to talk to your doc about taking a break or switching to Tamoxifen, which for the most part gave me no SEs and which I am now back on. We HER2 veterans are in a different category from ladies with ER+ cancer anyway--my onc was adamant that the benefits of anastrozole as compared to Tamoxifen for HER2 BC are so tiny (if any) as to be not worth the SEs.

Tiny Dancer--The joint pain is new for me but I've had the hobbling problem for a while (upon waking up in the morning and upon standing up from sitting) and assumed this was just aging (I'm 55). I never thought it was the Tamoxifen as that drug is not supposed to be associated with joint pain the way the AIs are. I also used to be unable to stand up from squatting--so forget about looking for a can of something or other in the back of a lower cabinet! After a few weeks of doing an aerobic exercise aerobic video with 2-lb weights, this problem improved a lot--my legs are stronger. Then everything went to hell again after my painting job (porch floor--scraping on my knees) and the anastrozole. It's all very confusing!

But I refuse to be slowed down, and darned if I wasn't out weeding the garden on my knees yesterday.

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jun 16, 2017 10:14AM wabals wrote:

Isabel I am taking a break from arimidex. I will tell my onc next time I see her. After only 4 days off it my joints are so much less painful. I am going to try tennis again!

Quality of life is very important

Dx 6/2015, IDC, Left, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ (FISH) Hormonal Therapy Radiation Therapy Surgery Lumpectomy: Left Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Jun 16, 2017 07:19PM - edited Jun 16, 2017 07:20PM by TinyDancer5

Isabel, I'm 53 and maybe my stiffness is from the monthly Lupron injections that I've been getting since last August. My MO wants to keep me on it for a year, so I hope when I see him again in August, I can finally stop.

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Jun 19, 2017 11:45AM IsabelArcher wrote:

Wabals, that is amazing that 4 days off already has results!

TinyDancer--I have forgotten what you are taking Lupron for...?

Dx 5/2013, IDC, <1cm, Stage IB, Grade 3, 0/0 nodes, ER+/PR+, HER2+ Surgery 7/8/2013 Mastectomy: Left; Reconstruction (left): Silicone implant Targeted Therapy 9/4/2013 Kadcyla (T-DM1, ado-trastuzumab)
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Jun 19, 2017 03:44PM TinyDancer5 wrote:

Estrogen levels were still high with the Tamoxifen, so MO added Lupron to stop the production of it

Dx 5/28/2015, IDC, Left, 1cm, Stage IA, Grade 3, 0/4 nodes, ER+/PR+, HER2+ Surgery 6/22/2015 Lumpectomy: Left; Lymph node removal: Sentinel Targeted Therapy 8/20/2015 Kadcyla (T-DM1, ado-trastuzumab) Radiation Therapy 11/10/2015 Whole-breast: Breast Hormonal Therapy 1/19/2016 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 8/26/2016
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Jun 20, 2017 12:07PM wabals wrote:

Isabel Archer on top of that I saw my hepatologist about my continuing elevated liver enzymes. Although just mildly up, it is very high for me. Liver sonogram only showed fatty liver. But additional labs showed autoimmune hepatitis. It is from arimidex I am sure. Tho rare it does happen and there is literature to prove it.

Anyone with elevated lifts do not let them tell you it is normal after chemo. Get it checked

Dx 6/2015, IDC, Left, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ (FISH) Hormonal Therapy Radiation Therapy Surgery Lumpectomy: Left Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)
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Jun 20, 2017 12:59PM carmstr835 wrote:

I thought I would share why I am no longer taking arimidex. I was prescribed arimidex prior to surgery. and it changed all my pathology from biopsy to treated surgical specimens. Everything was weaker hormone Ki-67, Her2 went from + to -. Not sure that pathology post arimidex is valid, though and I would prefer them to use my needle core biopsy to develop my treatment. I am not sure my oncologist is listening to me, but he eventually agreed to chemo, TC x4. I stopped the arimidex the day of chemo and been off now almost 5 weeks. My BP went from very high, on arimidex to very low, and my cholesterol when up 80 pts while on arimidex. I am now off all BP medications and I feel pretty good. I won't be going back on arimidex after chemo, we will try tamoxofin.

Dx 3/1/2017, DCIS/IDC, Both breasts, 1cm, Stage IIB, Grade 2, 2/17 nodes, ER+/PR-, HER2+ (FISH) Hormonal Therapy 3/21/2017 Arimidex (anastrozole) Surgery 3/27/2017 Lymph node removal: Right, Sentinel, Underarm/Axillary; Mastectomy: Left, Right Chemotherapy 5/17/2017 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Targeted Therapy 6/27/2017 Perjeta (pertuzumab) Targeted Therapy 6/27/2017 Herceptin (trastuzumab) Radiation Therapy 7/17/2017 Breast, Lymph nodes, Chest wall
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Jun 20, 2017 01:04PM - edited Jun 20, 2017 01:04PM by wabals

My bp also went down

Dx 6/2015, IDC, Left, <1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR+, HER2+ (FISH) Hormonal Therapy Radiation Therapy Surgery Lumpectomy: Left Targeted Therapy Kadcyla (T-DM1, ado-trastuzumab)

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